Biomarker and Genomic Sciences Group

The Biomarker and Genomic Sciences Group develops standards and methods for improving confidence in fundamental measurements in biology through new and improved techniques, methodologies, and standards based on optical and genomic methods. We are focused on improving the quantitative measurements of biological markers of gene expression in eukaryotic cells and biological fluids. We are providing tools that can be used for bioanalytical measurements pertinent to instrument calibration and analytical validation. We work with the stakeholders in the research and clinical analysis communities to determine their needs and opportunities where we can strategically focus our efforts. We identify the existing and future standards needs ranging from device calibration and instrument performance to the development of biological reference materials and procedures. The group has active projects in the development of genomic standards to support cancer diagnostics and therapeutics, in reference materials for quantitative flow cytometry, in the development of genomic markers for cell line authentication, and in measurements for assessing the results of genome editing.