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Simona Patange (Fed)
Biophysicist
Dr. Simona Patange is a Biophysicist with the NIST Material Measurement Laboratory, Biosystems and Biomaterials Division. Her research focuses on using single-cell measurements to understand sources of heterogeneity underlying CRISPR/Cas genome editing outcomes in human cells. Dr. Patange also leads projects on cell-based specificity measurements for the NIST Genome Editing Program and NIST Genome Editing Consortium.
Prior to NIST, Dr. Patange was a Research Fellow at the National Institutes of Health, combining optogenetic engineering with quantitative live-cell microscopy to determine how oncogenes alter RNA transcription events and transcription factor binding dynamics in human cells.
RESEARCH AREAS
- Single-cell Manipulation and Measurement
- Quantitative cellular imaging
- Gene expression analysis
- CRISPR/Cas editing systems
- Genome editing measurement assurance
- Genome in a Bottle cell characterization measurements
PROFESSIONAL ACTIVITIES
- Technical Proposal Reviewer, NIST SBIR Program (website)
- Chair, MML Accolades Review Committee, 2023
- Symposium co-chair, TechConnect World Innovation Conference, 2024-2025 (website)
- Co-organizer, NIH Light Microscopy Seminar Series, 2022-2025 (website)
Publications
- Patange S, Miller SD, Maragh S (2023). Variability in genome-engineering source materials: consider your starting point. Synthetic Biology 8(1), https://doi.org/10.1093/synbio/ysad003
- Patange S, Maragh S (2022). Fire Burn and Cauldron Bubble: What Is in Your Genome Editing Brew? ACS Biochemistry, Article ASAP. https://doi.org/10.1021/acs.biochem.2c00431
- Patange S, Ball DA, Wan Y, Karpova TS, Girvan M, Levens D, Larson DR. (2022). MYC amplifies gene expression through global changes in transcription factor dynamics. Cell Reports 38(4): 110292. https://doi.org/10.1016/j.celrep.2021.110292
- Patange S, Ball DA, Karpova TS, Larson DR. (2021). Towards a ‘spot on’ understanding of transcription in the nucleus. Journal of Molecular Biology 433(14):167016. https://doi.org/10.1016/j.jmb.2021.167016
- Patange S, Girvan M, Larson DR. (2018). Single-cell systems biology: Probing the basic unit of information flow. Current Opinion in Systems Biology 8:7-15. https://doi.org/10.1016/j.coisb.2017.11.011
- Martina M, Diab H, Jeong-A L, Lishu L, Patange S, Raben N, Puertollano R. (2014). The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris. Science Signaling 7:1-15. https://doi.org/10.1126/scisignal.2004754
Awards
- Invited Speaker, FDA Single-Cell OMICS Symposium, 2023
- Technical Award Finalist, NIST Postdoc and Early-Career Association of Researchers, 2023
- NIST NRC Postdoctoral Research Fellowship, 2020-2022
- Invited speaker, NCI Frontiers in Light Microscopy Symposium, 2019
- Platform Session Speaker, Biophysical Society Annual Meeting, 2019
- Honorable Mention, Ford Foundation Dissertation Fellowship, 2017
- NSF Research Fellowship in Network Biology, 2016
- Graduate Research Fellowship, NCI-UMD Partnership for Integrative Cancer Research, 2014-2016
- President’s List, Portland State University, 2010
- Gates Millennium Scholar, 2007-2011