Standard Reference Materials

FY2024 SRM Annual Sales Report

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The downloadable version of the SRM Catalog is updated annually. For the latest product availability for order, go to the NIST Store, https://shop.nist.gov.

Users of a NIST SRM or RM should ensure that the certificate/report in their possession is current. Find Current SRM/RM Certificates, Reports of Investigation, and Safety Data Sheets using the NIST Store’s Product Search Box.

Due to world events, all shipping to Russia, Belarus, and Ukraine has ceased. As a result, the Office of Reference Materials will not be accepting or processing orders to these countries for the foreseeable future.

News and Updates

SRM 2323 - Step Height Standard for Areal Surface Topography Measurement

NIST Developed an SRM to Aid the Forensic Analysis of Firearms and Toolmarks

July 30, 2025

When a gun is fired, microscopic markings are left on the expelled bullet and cartridge case. Forensic firearm and toolmark examiners compare these markings to

An RM for Assessing the Performance of Bioprocess Measurement Systems

June 30, 2025

After the release of NISTmAb RM 8671, the biopharmaceutical community noted that a monoclonal antibody (mAb) producing Chinese hamster ovary line (CHO) cell

Assuring the Accuracy of Metabolite Measurement and Identification

March 18, 2025

This reference material is intended to be used as quality assurance/quality control material for laboratory metabolomic measurements. Products of metabolism act

NIST Releases Reference Material to Aid Gut Microbiome Research

March 17, 2025

Researchers hope this material will help usher in a new era of diagnostics and treatments involving the gut microbiome.

Projects and Programs

NIST HER2 Genomic DNA Standard Reference Material, SRM® 2373

Ongoing

The amplification of the gene for HER2 occurs in approximately 20 to 25% of breast cancers. The accurate measurement of this biomarker is important for the proper treatment with anti-HER2 therapeutics. Clinical laboratories are beginning to utilize accurate and sensitive diagnostic tests based on

Press Coverage

Setting Standards for Stool

January 19, 2024

Microbiome studies have yielded hundreds of ideas for ways to detect and influence human health, but the field struggles with reproducibility...

The World Depends on a Strange Collection of Items. They're Not Cheap

Veritasium YouTube Channel

November 19, 2022

Steven Choquette, Benjamin Place, and Johanna Camara talk about the world of Standard Reference Materials.

Keeping up America’s standards is the job of NIST

The Economist

August 17, 2022

Melissa Phillips and NIST collaborators explain why NIST reference materials are so important to industry, monitoring environmental and human health, and much

Made to measure: why we can’t stop quantifying our lives

The Guardian

May 26, 2022

Dr. Steven Choquette, Director of the NIST Office of Reference Materials, is quoted in this article about metrology.

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