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Sierra Miller (Fed)


Sierra D. Miller, B.S. joined the Biomarker and Genomic Sciences Group as part of the NIST Genome Editing Program led by Dr. Samantha Maragh. Her bachelor’s honor thesis work investigated differential gene expression of Doryteuthis pealeii, squid, muscles via RNA-Seq.

At NIST, Sierra is a bioinformatician the Biosystems and Biomaterials Division primarily focused on validating computational genome editing analysis methods. Her work is part of the NIST Genome Editing Program where she is lead bioinformatician validating computational methods for genome editing off-target assays. Sierra also supports the NIST Genome Editing Consortium in working group projects to establish data/metadata norms for the genome editing field. She also works on establishing best practices for data management/infrastructure, reproducible research workflows, and metadata capture for the NIST Genome In A Bottle team.

Research Interests

  • Genome editing measurement assurance
  • RNA-Seq, genome assembly, variant calling
  • Data management and infrastructure
  • Metadata norms and best practices
  • Workflow management
  • Reproducible research


ORCID: 0000-0002-3200-428X

Orsburn, B.C., Miller, S.D., Jenkins, C.J. Standard Flow Multiplexed Proteomics (SFloMPro)—An
Accessible Alternative to NanoFlow Based Shotgun Proteomics. (2022) Proteomes. 2022; 10(1):3.

Khleifat, A.A., Smith, J.L., Blobner, B., Miller, S.D., Pagel, K., et. al. SnpReportR: A Tool for Clinical Reporting of RNAseq Expression and Variants. (2021) BioHackrXiv Preprints. DOI: 10.37044/

Martí-Carreras, J., Gener, A.R., Miller, S. D., Brito, A.F., Camacho, C.E., et al. NCBI’s Virus Discovery Codeathon: Building the “FIVE” – Federated Index of Viral Experiments API Database. (2020) Viruses. DOI: 10.3390/v12121424

Orsburn, B.C., Jenkins, C., Miller, S.D., Neely, B.A., Bumpus, N.N. In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19. (2020) bioRxiv 2020.03.08.980383; DOI: 10.1101/2020.03.08.980383


A Roadmap for LIMS at NIST Material Measurement Laboratory

Gretchen Greene, Jared Ragland, Zachary Trautt, June W. Lau, Raymond Plante, Joshua Taillon, Adam Abel Creuziger, Chandler A. Becker, Joe Bennett, Niksa Blonder, Lisa Borsuk, Carelyn E. Campbell, Adam Friss, Lucas Hale, Michael Halter, Robert Hanisch, Gary R. Hardin, Lyle E. Levine, Samantha Maragh, Sierra Miller, Chris Muzny, Marcus William Newrock, John Perkins, Anne L. Plant, Bruce D. Ravel, David J. Ross, John Henry J. Scott, Christopher Szakal, Alessandro Tona, Peter Vallone
Instrumentation generates data faster and in higher quantity than ever before, and interlaboratory research is in historic demand domestically and
Created May 27, 2020, Updated December 8, 2022