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Sierra Miller (Fed)


Sierra D. Miller, B.S., is a bioinformaticist in the Biosystems and Biomaterials Division & Biomarker and Genomic Sciences Group as part of the NIST Genome Editing Program led by Dr. Samantha Maragh.

At NIST, she is primarily focused on validating computational genome editing analysis methods. Her work is part of the NIST Genome Editing Program where she is lead bioinformaticist validating computational methods for genome editing off-target assays. Sierra also supports the NIST Genome Editing Consortium in working group projects to establish data/metadata norms for the genome editing field. She also works on establishing best practices for data management/infrastructure, reproducible research workflows, and metadata capture for the division and the NIST Genome In A Bottle team.

Research Interests

  • Genome editing measurement assurance
  • Off-target genome editing analysis
  • Bioinformatics analysis & data visualization
  • R | RMarkdown | RShiny
  • LIMS | data & metadata management & infrastructure
  • Metadata norms & best practices
  • Workflow management
  • Reproducible research
  • RNA-Seq, genome assembly, variant calling


ORCID: 0000-0002-3200-428X

  • Wang, L., Maragh, S.D., Kwee, E., Almeida, J.L., Miller, S.D., Eskandari, T., Lin-Gibson, S. Measurement solutions and standards for advanced therapy. (2024) Molecular Therapy - Methods & Clinical Development. 
  • Patange, S.; Miller, S.D.; Maragh, S.D. Variability in genome-engineering source materials: consider your starting point. (2023) Synthetic Biology. DOI: 10.1093/synbio/ysad003
  • Orsburn, B.C., Miller, S.D., Jenkins, C.J. Standard Flow Multiplexed Proteomics (SFloMPro) - An Accessible Alternative to NanoFlow Based Shotgun Proteomics. (2022) Proteomes. DOI: 10.3390/proteomes10010003
  • Khleifat, A.A., Smith, J.L., Blobner, B., Miller, S.D., Pagel, K., et. al. SnpReportR: A Tool for Clinical Reporting of RNAseq Expression and Variants. (2021) BioHackrXiv Preprints. DOI: 10.13140/RG.2.2.22058.34246
  • Martí-Carreras, J., Gener, A.R., Miller, S. D., Brito, A.F., Camacho, C.E., et al. NCBI’s Virus Discovery Codeathon: Building the “FIVE” – Federated Index of Viral Experiments API Database. (2020) Viruses. DOI: 10.3390/v12121424
  • Orsburn, B.C., Jenkins, C., Miller, S.D., Neely, B.A., Bumpus, N.N. In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19. (2020) bioRxiv 2020.03.08.980383; DOI: 10.1101/2020.03.08.980383



  • PO Learners, Today’s Leaders Award | Philipsburg-Osceola Area School District School Board | 2023
  • Most Outstanding Poster in Biological Sciences, Chemistry, and Mathematics | 30th Annual Early Career Poster Presentations NIST Chapter of Sigma Xi | 2023
  • Dr. William J Yurkiewicz Undergraduate Research Fellowship | Millersville University | 2019
  • Dean’s List | Millersville University | 2016-2019
  • 2nd Place Student Poster | 49th Annual Commonwealth of Pennsylvania University Biologists Conference | 2018


A Roadmap for LIMS at NIST Material Measurement Laboratory

Gretchen Greene, Jared Ragland, Zachary Trautt, June W. Lau, Raymond Plante, Joshua Taillon, Adam Abel Creuziger, Chandler A. Becker, Joe Bennett, Niksa Blonder, Lisa Borsuk, Carelyn E. Campbell, Adam Friss, Lucas Hale, Michael Halter, Robert Hanisch, Gary R. Hardin, Lyle E. Levine, Samantha Maragh, Sierra Miller, Chris Muzny, Marcus William Newrock, John Perkins, Anne L. Plant, Bruce D. Ravel, David J. Ross, John Henry J. Scott, Christopher Szakal, Alessandro Tona, Peter Vallone
Instrumentation generates data faster and in higher quantity than ever before, and interlaboratory research is in historic demand domestically and
Created May 27, 2020, Updated March 22, 2024