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Sierra Miller (Fed)


Sierra D. Miller, B.S. joined the Biomarker and Genomic Sciences Group as part of the NIST Genome Editing Program led by Dr. Samantha Maragh. Her bachelor’s honor thesis work investigated differential gene expression of Doryteuthis pealeii, squid, muscles via RNA-Seq.

At NIST, Sierra is a bioinformatician the Biosystems and Biomaterials Division primarily focused on validating computational genome editing analysis methods. Her work is part of the NIST Genome Editing Program where she is lead bioinformatician validating computational methods for genome editing off-target assays. Sierra also supports the NIST Genome Editing Consortium in working group projects to establish data/metadata norms for the genome editing field. She also works on establishing best practices for data management/infrastructure, reproducible research workflows, and metadata capture for the NIST Genome In A Bottle team.

Research Interests

  • Genome editing measurement assurance
  • Data management and infrastructure
  • Metadata norms and best practices
  • Workflow management
  • Reproducible research



Khleifat, A.A., Smith, J.L., Blobner, B., Miller, S.D., Pagel, K., et. al. SnpReportR: A Tool for Clinical Reporting of RNAseq Expression and Variants. (2021) BioHackrXiv Preprints. DOI: 10.37044/

Martí-Carreras, J., Gener, A.R., Miller, S. D., Brito, A.F., Camacho, C.E., et al. NCBI’s Virus Discovery Codeathon: Building the “FIVE” – Federated Index of Viral Experiments API Database. (2020) Viruses. DOI: 10.3390/v12121424

Orsburn, B.C., Jenkins, C., Miller, S.D., Neely, B.A., Bumpus, N.N. In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19. (2020) bioRxiv 2020.03.08.980383; DOI: /10.1101/2020.03.08.980383

Created May 27, 2020, Updated September 1, 2021