Testing methods that ensure cells are suitable for a particular screening, therapeutic, or production application are required to enable the engineering of cells to perform a desired function and to establish confidence in the performance of cells in these applications. Highly reliable measurements are increasingly critical when regulatory approval of a therapeutic product is involved.
Each of the 30 trillion cells that comprise the human body possesses a complete copy of that person’s genome, the 3 billion DNA base pairs that serve as the genetic code for building a human. Measurements of DNA sequence can be used to diagnose risk of cancer, select appropriate medical treatments, and customize those treatments for patients through personalized and precision medicine.
Spatially resolved and time-dependent information is often key to unlocking the mechanisms of biological phenomena. We develop novel, quantitative optical imaging techniques and robust image analysis software to support the rapidly evolving needs of the biosciences. Our strong expertise in optical methods provides the underpinning for a number of measurement assurance and technology development activities that serve the diagnostic, clinical, pharmaceutical, and biotechnology industries.
The interaction of proteins and cells with materials is pivotal to the success of many of today’s devices and pharmaceuticals. Reliable, robust measurements and standards that address this interaction are needed to maximize the success of commercial products and clinical outcomes. We address materials challenges associated with assuring the safety and performance of devices through the development of new materials, theories and models, measurement technologies, and standards.
Microbes play a critical role in health, agriculture, public safety, alternative energy, manufacturing and the environment. These applications demand reliability of identification, discrimination, and quantification of microbes at a level of speed and accuracy that is unprecedented. We collaborate with other federal agencies, companies and academic groups to identify the most pressing measurement challenges and the best approaches for meeting them.