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Justin Zook (Fed)

Co-Leader, Biomarker and Genomic Sciences Group

Dr. Justin Zook is co-leading the Genome in a Bottle Consortium’s work developing authoritatively characterized human genomes to benchmark sequencing methods. He developed methods to compare and integrate whole genome DNA sequencing data from multiple platforms and sequencing runs to characterize the first whole human genome Reference Materials.  He is now leading the GIAB Analysis Team work combining short, linked, and long read sequencing technologies to characterize structural variation and challenging regions of the genome.  He co-led the variants team in the Telomere-to-Telomere Consortium demonstrating the utility of the first complete human genome. He was an Informatics Representative to the Association for Molecular Pathology Clinical Practice Committee, and he chaired the Global Alliance for Genomics and Health Benchmarking Team, which published best practices for benchmarking genome sequencing results in 2019. He has co-authored >60 papers, including in Science, Nature Biotechnology, Nature Methods, JAMA, and Cell Genomics, and he wrote a blog about the inspiration for his NIST work.  

Research Opportunities

NIST-NRC Postdoctoral Fellowship: 2-year fellowship at NIST, US citizens only, ~$75,000 salary plus benefits, relocation expenses included, application deadlines are Feb. 1 and Aug. 1, requires 10 page research proposal, contact me if interested in writing a proposal on a bioinformatics genomics research project. We have opportunities posted for metrology in Cancer GenomicsDiploid AssemblyEpigenomics and TranscriptomicsBiological Data Science/Machine Learning, and Precision Medicine.

For additional job opportunities in genome bioinformatics, including for non-US citizens, contact me at my email address in the panel to the right.

    Awards

    Department of Commerce Gold Award
    Presidential Early Career Award for Scientists and Engineers (PECASE)
    NIST Judson C. French Award
    Council for Chemical Research Rising Star Award
    NIST/NRC Postdoctoral Research Fellowship
    NSF Graduate Research Fellowship

    Publications

    The complete sequence of a human Y chromosome

    Author(s)
    Arang Rhie, Sergey Nurk, Monika Cechova, Savannah Hoyt, Dylan Taylor, Nathanael David Olson, Justin Zook, Adam Phillippy
    The human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem

    A Draft Human Pangenome Reference

    Author(s)
    Wen-Wei Liao, Mobin Asri, Jana Ebler, Jennifer McDaniel, Nathanael David Olson, Justin Wagner, Justin Zook, Erik Garrison, Tobias Marschall, Ira Hall, Heng Li, Benedict Paten
    Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from

    FixItFelix: improving genomic analysis by fixing reference errors

    Author(s)
    Sairam Behera, Jonathan LeFaive, Peter Orchard, Justin Zook, Fritz Sedlazeck
    The current version of the human reference genome, GRCh38, contains a number of errors including 1.2 Mbp of falsely duplicated and 8.04 Mbp of collapsed regions
    Created September 24, 2019, Updated April 26, 2023