Nathanael David Olson

Publications

The allosteric landscape of the lac repressor

May 21, 2021

Author(s)

Drew S. Tack, Peter Tonner, Abe Pressman, Nathanael David Olson, Eugenia Romantseva, Nina Y. Alperovich, Olga B. Vasilyeva, David Ross, Sasha F. Levy

Allostery is a fundamental biophysical mechanism where the activity of a biomolecule is regulated by the binding of a ligand. Despite playing a central role in

A robust benchmark for detection of germline large deletions and insertions

June 15, 2020

Author(s)

Justin Zook, Nathanael David Olson, Marc Salit, Fritz Sedlazeck

New technologies and analysis methods are enabling genomic structural variants (SVs) to be detected with ever-increasing accuracy, resolution and

Assembly and annotation of an Ashkenazi human reference genome

June 2, 2020

Author(s)

Justin M. Zook, Justin M. Wagner, Nathanael D. Olson, Steven L. Salzberg, Alaina Shumate, Aleksey V. Zimin, Daniela Puiu, Mihaela Pertea, Marc Salit

Thousands of experiments and studies use the human reference genome as a resource each year. This single reference genome, GRCh38, is a mosaic created from a

Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome

August 12, 2019

Author(s)

Justin M. Zook, Nathanael D. Olson, Aaron Wenger

The DNA sequencing technologies in use today produce either highly accurate short reads or less-accurate long reads. We report the optimization of circular

High-coverage, long-read sequencing of Chinese trio reference samples

June 14, 2019

Author(s)

Justin M. Zook, Nathanael D. Olson, Marc L. Salit, Aaron Wenger, Chunlin Xiao, Robert Sebra

Genome In a Bottle (GIAB) is a consortium hosted by the National Institute of Standards and Technology whose primary objective is the development and

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Nathanael David Olson (Fed)

Publications