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Jennifer McDaniel (Fed)
Biologist, Biomarker and Genomic Sciences Group
Jennifer McDaniel has been engaged in genome-scale measurements and standards development since coming to NIST in 2005. She started in the wet lab leading laboratory operations in developing standards for gene expression and whole genome sequencing measurements. She is currently serving as a bioinformatician on the Genome in a Bottle (GIAB) team contributing to the development of germline and somatic, small and structural variant benchmarks and development of tumor-normal paired reference materials. She contributes to organizing and managing GIAB consortium-contributed genome-scale datasets, ensuring their public availability and thorough documentation. This work establishes comprehensive, transparent and accessible resource for human genome sequencing variant calling benchmarking activities, including analytical validation, technology development, optimization, and demonstration. This work supports the NIST mission to advance U.S. innovation through leading-edge measurement science, standards, and technology. Additionally, Jennifer serves as the Division Deputy Quality Manager supporting division staff in understanding and adherence to the requirements of the NIST Quality System.
CURRENT PROJECTS
Genome in a Bottle
Cancer Genome in a Bottle
- Nature Scientific Data publication describing the project and data: Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair (https://doi.org/10.1038/s41597-025-05438-2)
Vector Copy Number Reference Materials
NIST REFERENCE MATERIAL WORK
- Utah/European (daughter), HG001, RM8398
- Ashkenazi Jewish Family Trio (Son HG-002, Father HG-003, Mother, HG-004), RM8392
Han Chinese (Son), HG005, RM8393
Awards
NIST Material Measurement Laboratory Accolade for Measurment Services Excellence, 2023
For outstanding management of the larges,most diverse set of publicly avialable cancer genome data for a new broadly consented tumor cell line
U.S. Department of Commerce Silver Medal , 2022
For contribution to mapping the first ever complete human reference genome
NIST Material Measurement Laboratory Accolade for Service and Support , 2020
For coordinating on-site monitoring of NIST facilities during pandemic mandatory telework period
U.S. Department of Commerce Gold Medal, 2019
For advancement of human genomics metrology
NIST Judson C. French Award , 2017
For development of human genome Reference Materials and methods for expression of confidence
U.S. Department of Commerce Silver Medal , 2015
For work with the External RNA Control Consortium (ERCC) to develop gene expression measurement controls leading to release of NIST SRM 2374