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Jerilyn Izac (Fed)


Research Interests

  1. Nanoparticle flow cytometry
  2. Quantitative assessments of immune responses to vaccination or infection
  3. Biomarkers and quantitative flow cytometric measurements
  4. Viral Vector characterization for cell and gene therapy

Past Publications

R. D. Smith, J. R. Izac, M. Ha, H. Yang, J. Johnson, R. Ernst. Rapid identification of mcr- 1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay. Assess Microbiol. 2021. PMID: 35024564

R. D. Smith, C. McElheny, J. R. Izac, F. Gardner, C. Chandler, D. Goodlett, Y. Doi, J. Johnson, and R. Ernst. A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin Resistant Enterobacter Species. Microbiology Spectrum. 2021. PMID: 35107363

A. Singh and J. R. Izac, E. J.A. Schuler, D. T. Patel, C. Davies, R. T. Marconi. High resolution crystal structure of the Borreliella burgdorferi PlzA protein in complex with c-di-GMP: new insights into the interaction of c-di-GMP with the novel xPilZ domain. Pathog Dis. 2021. PMID: 34117751 

R. S. Green, J. R. Izac, W. A. Naimi, N. S. O'Bier, E. B. Breitschwerdt, R. T Marconi, J. A. Carlyon. Ehrlichia chaffeensis EplA interaction with host cell protein disulfide isomerase promotes infection. Front. Cell. Infect. Microbiol. 2020. PMID: 33072622

J. R. Izac, A. C. Camire, Edward JA Schuler, Amanda M. Hatke, N. S. O’Bier, and R. T. Marconi. Serologic Evidence for the Exposure of Eastern Coyotes (Canis latrans) in Pennsylvania to the Tick-Borne Pathogens Borreliella burgdorferi and Anaplasma phagocytophilum. mSphere. 12;5(4). 2020. PMID: 32817454

W. A. Naimi, J. J. Gumpf, R. S. Green, J. R. Izac, M. P. Zellner, D. H. Conrad, R. T. Marconi, R. K. Martin, J. A. Carlyon. Immunization against Anaplasma phagocytophilum adhesin binding domains confers protection against infection in the mouse model. Infect Immun. IAI.00106-20. 2020. PMID: 32661123

J. R. Izac, N. S. O’Bier, L. D. Oliver, Jr., A. C. Camire, C. G. Earnhart, D. V. LeBlanc Rhodes, B. F. Young, S. R. Parnham, C. Davies and R. T. Marconi. Development and optimization of OspC chimeritope vaccinogens for Lyme disease. Vaccine. 8;38(8):1915-1924 2020. PMID: 31959423

J. R. Izac and A. C. Camire, R. T. Marconi. Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses. Vaccine. 17;37(17):2401-2407. 2019. PMID: 30922701

J. R. Izac and R. T. Marconi. Diversity of the Lyme disease spirochetes and its influence on immune response to infection and vaccination. Guest Editor, Annette Lister; Vet Clin North Am Small Anim Pract. 2019. PMID: 30967254

J. L. Kostick-Dunn, J. R. Izac, J. C. Freedman, L. T. Szotknicki, L. D. Oliver Jr., R. T. Marconi. “The Borrelia burgdorferi c-di-GMP binding receptors, PlzA and PlzB, are functionally distinct”. Frontiers in Microbiology. 8(213). 2018. PMID: 30050868                  

J. R. Izac, L. D. Oliver Jr., C. G. Earnhart, R.T. Marconi. “Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: implications for vaccine development”. Vaccine. 35(24): 3178-3185. 2017. PMID: 28479174.

K.S. Hebert, D. Seidman, A. T. Oki, J. Izac, S. Emani, L. D. Oliver Jr., D. P. Miller, B. K. Tegels, R. Kannagi, R. T. Marconi, J. A. Carlyon. “Anaplasma marginale Outer Membrane Protein A Is an Adhesin That Recognizes Sialyated and Fucosylated Glycans and Functionally Depends on an Essential Binding Domain”. Infection and Immunity. 85(3). 2017. PMID: 27993973.

Created September 1, 2021, Updated May 1, 2023