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https://www.nist.gov/people/zhiyong-he
Zhiyong He (Fed)
Biologist
Research interests
Developing reference materials for cancer biomarkers, such as methylated genomic DNA and cfDNA for DNA methylation measurements.
Developing Lentiviral vector (LVV) copy number reference materials, developing LVV titer measurement methods and LVV genome integrity measurement methhods.
Developing immune-therapy CAR-T reference materials and protocols for measurements.
Background: Existing human cell immortalization methods made the cells obtain oncogenesis phenotype and/or caused the cells gain and/or lose chromosomes
Zhiyong He, Edward Kwee, Megan Cleveland, Kenneth Cole, Sheng Lin-Gibson, Hua-Jun He
Abstract Lentiviral vectors (LV) have proven to be powerful tools for stable gene delivery in both dividing and non-dividing cells. Approval of these LVs for