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Zhiyong He (Fed)

Biologist

Biomarker and Genomic Sciences Group

zhiyong.he [at] nist.gov

(301) 975-8105

ORCID iD

0009-0002-4650-2826

Staff Employment

Biologist - NIST

Associate - Albert Einstein College of Medicine

Post Doc - Mount Sinai School of Medicine

Post-Graduate Researcher - University of California Davis

Staff Education

B.S. Biochemistry and Microbiology, Zhejiang University

M.S. Biochemical Engineering, Zhejiang University of Technology

Ph. D. Biomedical Engineering, Shanghai Jiao-Tong University and Shanghai Institute of Biochemistry, Chinese Academy of Sciences

Research interests

Developing reference materials for cancer biomarkers, such as methylated genomic DNA and cfDNA for DNA methylation measurements.
Developing Lentiviral vector (LVV) copy number reference materials, developing LVV titer measurement methods and LVV genome integrity measurement methhods.
Developing immune-therapy CAR-T reference materials and protocols for measurements.
Developing tumor and matched normal cell lines.

Publications

Immortalization of Human Primary CD8+ T cells by Inserting a Single Copy of Human Telomerase Reverse Transcriptase via CRISPR/Cas9

April 25, 2025

Author(s)

Zhiyong He, Kenneth Cole, Hua-Jun He

Background: Existing human cell immortalization methods made the cells obtain oncogenesis phenotype and/or caused the cells gain and/or lose chromosomes

Quantitation and integrity evaluation of RNA genome in lentiviral vectors by direct reverse transcription-droplet digital PCR (direct RT-ddPCR)

September 2, 2023