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Hua-Jun He (Fed)
Biologist
Research Interests
- Standards & reference materials development for cancer biomarker measurements. Currently, we are working on the development of circulating cell-free tumor DNA (ctDNA), cell-free DNA (cfDNA) methylation, cfRNA, extracellular vesicles and other cancer biomarker reference materials for liquid biopsy. In addition, we are working on the development of next generation cell-based reference materials: a) broadly consented and characterized human tumor and matched normal cell lines for multi-omics cancer biomarker detection and benchmark testing; and b) chimeric antigen receptor-T (CAR-T) cell, CAR-NK (natural killer) and CAR engineered in other type of human cell lines for standardization of cell therapy.
- Metrology for cancer biomarker and biosystems. We are working on the development of digital PCR and next-generation sequencing (NGS) based robust and sensitive assays for rare allele genetic and epigenetics alterations. Other interests include adopting and validating emerging technologies for fast, sensitive, specific, and accurate cancer biomarker measurements, such as electric field induced release and measurements (EFIRM), lateral flow assays and other portable devices for liquid biopsy.
Research Opportunities
NIST-NRC Postdoctoral Research Associateship Program: 2-year fellowship at NIST, US citizens only, competitive salary plus benefits, travel stipend and relocation expenses. Application deadlines are Feb. 1 and Aug. 1. Requires a 10-page research proposal plus additional materials. Contact me if interested in writing a research proposal on cancer biomarker measurements.
Current opportunities available:
Interlaboratory Testing Program