Biomaterials Group

The Biomaterials Group portfolio includes mammalian cell measurements, microbial cell measurements, biomaterials and cell-material interactions, and advanced imaging and spectroscopy. These efforts bolster the development and translation of regenerative medicine and advanced protein-, cell-, and microbe-based therapeutics in support of the bioeconomy.

Projects and programs

Mammalian Cell Measurements: Quantification and characterization of mammalian cell and cell system properties in support of the generation, translation, and biomanufacturing of cell therapy and regenerative medicine products.

Microbial Measurements: Methods, technologies, and standards to quantify microbial cells and complex microbial communities to address critical measurement needs in industry and biodefense.

Biomaterials & Cell-Material Interactions: Quantitative measurements of biomaterial properties and the biological and microbial response to biomaterials to advance regenerative medicine and medical device technologies.
Advanced Imaging & Spectroscopy: Novel spectral, imaging, and quantum methods to characterize and quantify molecular content of biological systems and materials.
- Label-Free Chemical Imaging
- High-Sensitivity Spectroscopy
- Quantum Bioimaging
- 3D Molecular Orientation Imaging

News and Updates

NIST Develops Yeast Material for Training First Responders on Biothreats

January 4, 2023

Researchers based the material on baker’s yeast because it is harmless and a living biological material.

Molecules Have an Orientation, and Scientists Have a New Way to Measure It

December 8, 2022

Molecular orientation is key to designing better materials.

cartoon cow and chicken using slingshots to fling pairs of entangled photons through a glass of milk and a chicken cutlet

Spotlight: Two Photons Walk Into a Chicken

May 26, 2021

In weird but potentially practical news, NIST researchers headed to the grocery store to find out. Not as a joke, but as a step toward better imaging methods

A man (Young Jong Lee) in a red shirt and safety goggles leans over a piece of scientific equipment.

Spotlight: Young Jong Lee

January 18, 2020

What are you made of? With a new measurement technique from NIST’s Young Jong Lee, scientists can answer that question on the cellular level with 100 times more

Biomaterials Group Publications

Three-dimensional, label-free cell viability measurements in tissue engineering scaffolds using optical coherence tomography

March 14, 2023

Author(s)

Greta Babakhanova, Anant Agrawal, Deepika Arora, Allison Horenberg, Jagat Budhathoki, Joy Dunkers, Joe Chalfoun, Peter Bajcsy, Carl Simon Jr.

In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue

Measuring Dimensionality of Cell-Scaffold Contacts of Primary Human Bone Marrow Stromal Cells Cultured on Electrospun Fiber Scaffolds

January 1, 2023

Author(s)

Carl Simon Jr., Peter Bajcsy, Joe Chalfoun, Michael Paul Majurski, Mary C. Brady, Mylene Simon, Nathan Hotaling, Nick Schaub, Allison Horenberg, Piotr Szczypinski, Dongbo Wang, Veronica DeFelice, Soweon Yoon, Stephanie Florczyk

The properties and structure of the cellular microenvironment can influence cell behavior. Sites of cell adhesion to the extracellular matrix (ECM) initiate

3D Orientation Imaging of Polymer Chains with Polarization-Controlled Coherent Raman Microscopy

December 7, 2022

Author(s)

Shuyu Xu, Young Jong Lee

Despite the ubiquity of three-dimensional (3D) anisotropic materials, their 3D molecular alignment cannot be measured using conventional two-dimensional (2D)

Standards to Support an Enduring Capability in Wastewater Surveillance for Public Health: Where Are We?

December 1, 2022

Author(s)

Stephanie Servetas, Kirsten Parratt, NIchole Brinkman, Orin Shanks, Ted Smith, Philip Mattson, Nancy Lin

The COVID-19 pandemic highlighted a wide range of public health system challenges for infectious disease surveillance. The discovery that the SARS-CoV-2 virus

Effects of Salts and Surface Charge on the Biophysical Stability of a low pI Monoclonal Antibody

November 15, 2022

Author(s)

Kelvin B. Rembert, Young Jong Lee, Jifeng Zhang

The impact of five representative Hofmeister salts (NaCl, KCl, MgCl2, Na2SO4, and NaSCN) on the thermal stability and aggregation kinetics of a slightly acidic

Biomaterials Group

Projects and programs

News and Updates

NIST Develops Yeast Material for Training First Responders on Biothreats

Molecules Have an Orientation, and Scientists Have a New Way to Measure It

Spotlight: Two Photons Walk Into a Chicken

Spotlight: Young Jong Lee

Biomaterials Group Publications

Three-dimensional, label-free cell viability measurements in tissue engineering scaffolds using optical coherence tomography

Measuring Dimensionality of Cell-Scaffold Contacts of Primary Human Bone Marrow Stromal Cells Cultured on Electrospun Fiber Scaffolds

3D Orientation Imaging of Polymer Chains with Polarization-Controlled Coherent Raman Microscopy

Standards to Support an Enduring Capability in Wastewater Surveillance for Public Health: Where Are We?

Effects of Salts and Surface Charge on the Biophysical Stability of a low pI Monoclonal Antibody

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