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Young Jong Lee
Research Chemist, Project Leader
Since Young Jong Lee joined NIST in 2006, he has been developing new hyperspectral imaging and spectroscopy technologies based on coherent Raman and infrared (IR) absorption to measure the quantitative and structural information of complex materials and biological systems. His research has been extended to development of new spectroscopic methods for non-invasive, high-sensitivity characterization of higher-order structures of protein and polymers.
CURRENT RESEARCH INTERESTS
Development of New Measurement Technology
- Label-free chemical imaging by broadband coherent anti-Stokes Raman scattering (BCARS) microscopy
- Advanced high-sensitivity IR spectroscopy to characterize the higher order structure of protein using quantum cascade lasers (QCL)
- Imaging the 3D angles and the order parameter of molecular orientation using polarization-controlled IR/Raman microscopy
- Advanced analysis of complex spectra using 2-dimensional correlation spectroscopy (2DCOS)
Therapeutic Proteins
- Spectral characterization of the higher-order structures of protein
- Biophysical stability (unfolding/aggregation) of formulation drugs
Soft Matter Physics
- Molecular structure of semicrystalline polymers
- Changes in structure and orientation of polymers under mechanical strain
Cell Systems and Tissues
- Label-free functional imaging of stem cells for regenerative medicine
- In-situ, non-invasive spectroscopic measurement of cell viability
JOB OPPORTUNITIES
Postdocs or Guest Researchers: open to either non-US citizens or US citizens. If interested in any projects described above, please send an email to youngjong.lee@nist.gov
NRC Postdoctoral Fellowship: US citizens only. Please visit the following opportunities.
- Coherent Raman Imaging of Biomineralization Processes in Stem Cells
- Advanced Coherent Raman Imaging for Polymer Physics
- Advanced Vibrational Spectroscopy of Higher Order Structures of Protein
SELECTED PUBLICATIONS
- Y. J. Lee, Concurrent Polarization IR Analysis to Determine the 3D Angles and the Order Parameter for Molecular Orientation Imaging, Opt. Express 26, 24577 (2018).
- Y. Jin, A. P. Kotula, A. R. Hight Walker, K. B. Migler, Y. J. Lee, Raman Identification of Multiple Melting Peaks of Polyethylene, Macromolecules 50, 6174 (2017).
- Y. J. Lee, Least Squares Moving-Window Spectral Analysis, Appl. Spectrosc. 71, 1894 (2017).
- I. S. Ryu, C. H. Camp Jr., Y. Jin, M. T. Cicerone, Y. J. Lee, Beam Scanning for Rapid Coherent Raman Hyperspectral Imaging, Opt. Lett. 40, 5826 (2015).
- Y. J. Lee, S. L. Vega, P. J. Patel, K. A. Aamer, P. V. Moghe, M. T. Cicerone, Quantitative, Label-Free Characterization of Stem Cell Differentiation at the Single-Cell Level by Broadband Coherent Anti-Stokes Raman Scattering Microscopy, Tissue Eng. Part C 20, 562 (2014).
- Y. J. Lee, C. R. Snyder, A. M. Forster, M. T. Cicerone, W. Wu, Imaging the Molecular Structure of Polyethylene Blends with Broadband Coherent Raman Microscopy, ACS Macro Lett. 1, 1347 (2012).
- Y. J. Lee, S. H. Parekh, F. A. Fagan, M. T. Cicerone, Phonon Dephasing and Population Decay Dynamics of the G-band of Semiconducting Single-Wall Carbon Nanotubes. Phys. Rev. B 82, 165432 (2010).
- Y. J. Lee, Y. Liu, M. T. Cicerone, Characterization of 3-Color CARS in a 2-Pulse Broadband CARS Spectrum. Opt. Lett. 32, 3370 (2007).
= University of Texas at Austin =
- Y. J. Lee, S.-J. Park, A. J. Gesquiere, P. F. Barbara, Probing a Molecular Interface in a Functioning Organic Diode. Appl. Phys. Lett. 87, 051906 (2005).
- Y. J. Lee, D. Y. Kim, J. K. Grey, P. F. Barbara, Variable Temperature Single-Molecule Dynamics of MEH–PPV. ChemPhysChem 6, 2404 (2005).
- P. F. Barbara, A. J. Gesquiere, S.-J. Park, Y. J. Lee, Single Molecule Spectroscopy of Conjugated Polymers. Acc. Chem. Res. 38, 602 (2005).
- Y. J. Lee, T. Zhang, P. F. Barbara, Kinetics of Electron Attachment to Reverse Micelles. J. Phys. Chem. B 108, 5175 (2004).
= Seoul National University =
- S. M. Jin, Y. J. Lee, J. Yu, S. K. Kim, Development of Femtosecond Stimulated Raman Spectroscopy: Stimulated Raman Gain via Elimination of Cross Phase Modulation. Bull. Korean Chem. Soc. 25, 1829 (2004).
- Y. J. Lee, N. W. Song, S. K. Kim, Photoluminescence of C60 and Its Photofragments in the Gas Phase. J. Phys. Chem. A 106, 5582 (2002).
- Y. J. Lee, S. H. Cho, N. J. Kim, S. K. Kim, Anisotropy Quantum Beat in Two-Photon Ionization of Coherently Excited Hyperfine States of Na. J. Chem. Phys. 115, 739 (2001).