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Young Jong Lee (Fed)
Research Chemist, Project Leader
Since Young Jong Lee joined NIST in 2006, he has developed new microscopy and spectroscopy technologies based on coherent Raman and infrared (IR) absorption to measure the quantitative and structural information of complex materials and biological systems. His recent research has focused on developing new IR spectroscopic methods for the high-sensitivity characterization of proteins and new microscopic methods based on IR and Raman-based for live cells and polymers. (orcid.org/0000-0001-7754-3001)
CURRENT RESEARCH INTERESTS
Development of New Measurement Technology
- Label-free chemical imaging by broadband coherent anti-Stokes Raman scattering (BCARS) microscopy
- Advanced high-sensitivity IR spectroscopy to characterize the higher-order structure of proteins using quantum cascade lasers (QCL)
- Imaging the 3D orientation angles using polarization-controlled IR/Raman microscopy
- Advanced analysis of complex spectra using 2-dimensional correlation spectroscopy (2DCOS)
Therapeutic Proteins
- High-sensitivity characterization of the secondary structures of protein
- Biophysical stability (unfolding/aggregation) of formulation drugs
Soft Matter Physics
- Molecular structure and orientation of semicrystalline polymers
- Changes in the alignment and crystallinity of polymer chains under mechanical strain
Cell Systems and Tissues
- Label-free functional imaging of stem cells in scaffolds for regenerative medicine
- In-situ, non-invasive spectroscopic imaging of biofilms
JOB OPPORTUNITIES
Postdocs: positions may be occasionally available. Both non-US citizens and US citizens. If interested in any projects described above, please send an email to youngjong.lee [at] nist.gov.
NRC Postdoctoral Fellowship: US citizens only. Please visit the following opportunities.
- Mapping Responses in Complex Microbial Systems using Advanced Imaging
- Advanced Vibrational Spectroscopy of Higher-Order Structures of Protein
SELECTED PUBLICATIONS
- S. Xu, J. Rowlette, Y. J. Lee, Imaging 3D molecular orientation by orthogonal-pair polarization IR microscopy, Opt. Express 30, 8436 (2022).
- B. Chon, S. Xu, Y. J. Lee, Compensation of Strong Water Absorption in Infrared Spectroscopy Reveals the Secondary Structure of Proteins in Dilute Solutions, Anal. Chem. 93, 2215 (2021).
- Y. Jin, A. P. Kotula, A. R. Hight Walker, K. B. Migler, Y. J. Lee, Raman Identification of Multiple Melting Peaks of Polyethylene, Macromolec. 50, 6174 (2017).
- I. S. Ryu, C. H. Camp Jr., Y. Jin, M. T. Cicerone, Y. J. Lee, Beam Scanning for Rapid Coherent Raman Hyperspectral Imaging, Opt. Lett. 40, 5826 (2015).
- Y. J. Lee, S. L. Vega, P. J. Patel, K. A. Aamer, P. V. Moghe, M. T. Cicerone, Quantitative, Label-Free Characterization of Stem Cell Differentiation at the Single-Cell Level by Broadband Coherent Anti-Stokes Raman Scattering Microscopy, Tissue Eng. Part C 20, 562 (2014).
- Y. J. Lee, C. R. Snyder, A. M. Forster, M. T. Cicerone, W. Wu, Imaging the Molecular Structure of Polyethylene Blends with Broadband Coherent Raman Microscopy, ACS Macro Lett. 1, 1347 (2012).
