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Young Jong Lee (Fed)
Research Chemist, Project Leader
Since Young Jong Lee joined NIST in 2006, he has developed new spectral imaging technologies based on coherent Raman scattering and infrared (IR) absorption. His recent research has focused on the development of the quantitative and structural measurement for complex materials and biological systems. (orcid.org/0000-0001-7754-3001).
CURRENT RESEARCH INTERESTS
Development of New Measurement Technology
- Label-free chemical imaging by broadband coherent anti-Stokes Raman scattering (BCARS) microscopy
- Advanced high-sensitivity solvent absorption compensation (SAC) IR spectroscopy using quantum cascade lasers (QCL)
- 3D orientation imaging using polarization-controlled IR and BCARS microscopy
- Advanced analysis of complex spectra using 2-dimensional correlation spectroscopy (2DCOS)
- Live cell imaging of biomolecules using label-free SAC-IR microscopy
- High-sensitivity chemical imaging of microplastics
Therapeutic Proteins
- Quantitative spectroscopy of the higher-order structure of proteins
- Biophysical stability (unfolding/aggregation) of protein drugs
Soft Matter Physics
- Molecular structure of semicrystalline polymers
- Structural changes of polymers under mechanical strain
- Spectral identification of microplastics
Cell Systems and Tissues
- Label-free functional imaging of stem cells for regenerative medicine
- Chemical imaging of biofilms and bacterial systems
- Quantitative spectral identification of live cells
EMPLOYMENT OPPORTUNITIES
Postdocs (Guest Researchers): open to either non-US citizens or US citizens.
NRC Postdoctoral Fellowship: US citizens only. Please visit the following opportunities.
- Label-Free Cell Imaging Using Advanced Vibrational Spectroscopy
- Advanced Imaging of Biomaterials and Smart Polymers
- Advanced Vibrational Spectroscopy of Proteins
- Mapping Reponses in Complex Microbial Systems using Advanced Imaging
If interested in any projects described above, please email at youngjong.lee [at] nist.gov.
SELECTED PUBLICATIONS
- S. Xu, Y. Jin, Y. J. Lee, 3D orientation imaging of polymer chains with polarization-controlled coherent Raman microscopy, J. Am. Chem. Soc. 144, 23030 (2022).
- S. Xu, J. Rowlette, Y. J. Lee, Imaging 3D molecular orientation by orthogonal-pair polarization IR microscopy, Opt. Express 30, 8436 (2022).
- B. Chon, S. Xu, Y. J. Lee, Compensation of Strong Water Absorption in Infrared Spectroscopy Reveals the Secondary Structure of Proteins in Dilute Solutions. Anal. Chem. 93, 2215 (2021).
- Y. J. Lee, S. L. Vega, P. J. Patel, K. A. Aamer, P. V. Moghe, M. T. Cicerone, Quantitative, Label-Free Characterization of Stem Cell Differentiation at the Single-Cell Level by Broadband Coherent Anti-Stokes Raman Scattering Microscopy, Tissue Eng. Part C 20, 562 (2014).
- Y. J. Lee, C. R. Snyder, A. M. Forster, M. T. Cicerone, W. Wu, Imaging the Molecular Structure of Polyethylene Blends with Broadband Coherent Raman Microscopy, ACS Macro Lett. 1, 1347 (2012).
- Y. J. Lee, Y. Liu, M. T. Cicerone, Characterization of 3-Color CARS in a 2-Pulse Broadband CARS Spectrum. Opt. Lett. 32, 3370 (2007).
