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Chemistry

Analytical chemistry

News and Updates

Blog Posts

Brad Sutliff wears safety glasses as he stands in the lab in front of a computer monitor.

From Trash to Cash: How AI and Machine Learning Can Help Make Recycling Less Expensive for Local Governments

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Melissa Phillips, wearing safety glasses, poses leaning over an open chest freezer, holding a plastic bag of spinach.

Organic, Vegetarian or Carnivore: Whatever You Eat, My Lab Is Working to Keep It Safe

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A neon sign that reads Welcome to Fabulous Las Vegas is lit up in neon in front of a sunset scene.

When Neon Was New: How NIST Researchers Helped America Discover the Iconic Neon Sign

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Events

Projects and Programs

A Comparison of WD-EPMA Heterogeneity Testing Procedures

Ongoing
X-ray stage mapping (XSM) can be used to determine the extent of heterogeneity on the micron scale though it is more time consuming and not as accurate as the more rigorous NIST random-point (RP) testing procedure. The objective of this work is to demonstrate the advantage of the latter procedure
A schematic overview showing the distribution of the standardized samples to study participants, the use of standardized protocols for measurements, and standardized reporting of data back to NIST for analysis.

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2
diagram of lab information management system

Advanced Fluid Characterization - Laboratory Information Management System

Ongoing
Breath sampling of cannabis users. In July 2019, the National Institute of Justice awarded our team funding for a three-year project to provide the chemical foundation for industry to develop a cannabis breathalyzer. We are developing new experimental methods to enhance the clinical, thermodynamic

Advanced Mass Spectrometry Methods for Trace Detection

Ongoing
Ambient Ionization Mass Spectrometry (AI-MS) AI-MS remains a versatile field enabling direct analysis of samples in situ, requiring minimal or no sample preparation. These platforms are leveraged for the trace detection of organic and inorganic compounds, including, homemade and improvised

Publications

Software

DTSA II

NIST DTSA-II

NIST DTSA-II builds on the best available algorithms in the literature to simulate, quantify and plan energy dispersive x-ray analysis measurements.

NIST Mass and Fragment Calculator Software

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions

JB95 Spectral fitting program

A graphical user interface program, JB95, based on a Windows 95 © API platform has been written in the C programming language to aid in the analysis of complex
chromatography program

Simulated Chromatographic Data

The following information is provided as an aid in the validation of mathematical models used in quantitation with chromatographic data. This data may also be

Tools and Instruments

NIST Transition Edge Sensor Microcalorimeter.

Microcalorimeter Detector

The NIST transition edge sensor microcalorimeter is energy dispersive x-ray spectrometer capable of ~5 eV resolution over a range of energies from hundreds to

Awards

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