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Chemistry

Analytical chemistry

Projects/Programs

Displaying 1 - 25 of 139
A schematic overview showing the distribution of the standardized samples to study participants, the use of standardized protocols for measurements, and standardized reporting of data back to NIST for analysis.

AAPS Interlaboratory Study: Protein Aggregation and Immunogenicity

Ongoing
To ensure the safety and efficacy of protein-based biotherapeutics, manufacturers strive to avoid unwanted immune responses caused by the biotherapeutic. Protein immunogenicity is a complex topic and depends on multiple factors related to the product, patient profile, and treatment. 1 , 2
Photograph of a labeled amber bottle containing SRM 2429.

Activated Carbon and FGD Gypsum Standard Reference Materials

Completed
The role of mercury in the environment is now receiving close scrutiny because ultimately it can bioaccumulate as alkyl mercury in seafood with subsequent risk to human health through trophic transfer. Many industrial sources of mercury have been effectively reduced in recent years, but atmospheric
diagram of lab information management system

Advanced Fluid Characterization - Laboratory Information Management System

Ongoing
Breath sampling of cannabis users. In July 2019, the National Institute of Justice awarded our team funding for a three-year project to provide the chemical foundation for industry to develop a cannabis breathalyzer. We are developing new experimental methods to enhance the clinical, thermodynamic

Advanced Mass Spectrometry Methods for Trace Detection

Ongoing
Ambient Ionization Mass Spectrometry (AI-MS) AI-MS remains a versatile field enabling direct analysis of samples in situ, requiring minimal or no sample preparation. These platforms are leveraged for the trace detection of organic and inorganic compounds, including, homemade and improvised

Ambient and Atmospheric Pressure Mass Spectrometry

Ongoing
Surface and Trace Chemical Analysis Group employs a range of commercial pneumatically-assisted electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) sources for traditional mass spectrometric chemical analysis, identification
Hexagon containing words “environmental metabolomics” with arrows pointing from the hexagon to each of the following images: coral, shrimp, mussel, microbe, horseshoe crab, plant. The circle figure has waves and a tree faded in the background.

Applications in Metabolomics

Ongoing
The application of metabolomics techniques to systems biology reveals insights into model and non-model organism biology. The natural world contains undiscovered chemicals and mechanisms that can be harnessed by industry to create new biomanufacturing processes and products. Each biological system
Photograph of gas cylinders

Audit of EPA Protocol Gas Suppliers

Ongoing
Protocol gas standards are employed in measurements made for compliance purposes; one of the major uses is for measurements of regulated gaseous species from stationary source emitters, i.e., stack gases. Many of these stationary sources are regulated through the Cap and Trade program; therefore
Bioman lifecycle

Biomanufacturing Initiative

Ongoing
The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

Biomaterials for Oral Health

Completed
NIST along with its partners has a long commitment to scientific excellence with demonstrated impact in improving the oral health of the public. NIST researchers are leaders in this field and create a community by engaging other researchers, industry, and regulatory agencies to address urgent needs
Image showing a variety of gas tanks with carbon dioxide

Carbon Dioxide Measurements and Reference Materials

Ongoing
CO 2 Reference Materials The Gas Sensing Metrology Group at NIST has a long history of providing reference materials to industry, monitoring communities, and academia. The program began in the 1970’s by developing an initial suite of CO2 primary standard mixtures (PSMs) to support the US Department
Wordcloud consisting of words CCQM metrology group task etc.

CCQM Activities in the Gas Analysis Working Group

Ongoing
The results from these Key comparisons will be used to benchmark the appropriate Calibration and Measurement Claims (CMCs) of the participating NMIs. CMCs are basically the declared capabilities that an NMI offers to customers, and they are included in a searchable database at the BIPM web site
CCQM Intercomparisons

CCQM Activities in the Organic Analysis Working Group

Ongoing
The results from these studies will be used to demonstrate the capabilities of participating NMIs for their similar measurement services, and eventually benchmark the appropriate  Calibration and Measurement Capabilities (CMCs) that summarizes this capability.  NIST CMCs that directly support SI
Photograph of three Standard Reference Materials of various soil matrices.

Certification of Three Soil SRMs for Inorganic Environmental Measurements

Completed
The three NIST soil SRMs, 2709, 2710 and 2711, have been used worldwide by hundreds of laboratories; combined sales typically exceed 800 units per year. Use of these SRMs provides our customers with tools that are essential for achieving quality assurance in the analysis of contaminant elements in
Microhotplate platform used in developing gas microsensor technology.

Chemical/Biochemical Microsensor Science

Ongoing
Our research is focused on the basic and applied aspects of chemical sensor science and technology in the following areas: The development and evaluation of nanoscale materials, e.g., nanowires and nanotubes, for high-performance chemical sensing of gas-phase species Novel approaches for low-cost
Photograph of a unit of RM 8027 Silicon Nanoparticles (Nominal Diameter 2 nm) showing a labeled box and ampoules.

Chemical Characterization of Nanoparticles

Ongoing
NIST has a broad research program spread throughout the major operating units aimed at building the supporting technical capabilities that U.S. industry needs in their quest to develop new nanotech products with desirable new capabilities and bring them safely to market. The Chemical Sciences
Cannabis Buds

Chemical Foundations for a Cannabis Breathalyzer

Ongoing
NIST's initial work in cannabis science was a series of measurements of the vapor pressure of two important cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Our current effort is funded in part by interagency agreements with the National Institute of Justice and by the NIST
Photograph of titanium metal crystal with cubic symmetry.

Chemical Metrology for Metals, Ores, and Related Materials

Ongoing
In the arena of industrial commodities, the primary challenges are to provide measurement tools and reference materials that allow U.S. industry to establish comparability of measurement results to results obtained by customers, competitors, and regulators for the basic chemical properties of
Photograph of three labeled bottles of SRM 2855 containing low-density and high density polyethylene

Chemical Metrology for Polymers Manufacturing

Ongoing
This project is designed to strengthen the analytical capabilities of polymers manufacturers by introducing reference materials, critically evaluating standard test methods, and educating those industry representatives who participate in standards development organizations. Certified reference
Illustration of satellite sensing of sunlight reflected by buildings, roads, water and trees to assess radiative warming of the earth.

Climate Science

Ongoing
This program encompasses multifaceted efforts to advance the metrology of climate science. Projects include: development of ultra-high accuracy optical standards and technologies to determine greenhouse gases (GHGs) concentrations, atmospheric lifetimes, and aerosol radiative forcing development of

Clinical and Forensic Reference Materials

Ongoing
Below is a listing of the reference materials currently produced by the Applied Genetics group. Clinical Diagnostics SRM 2393 - CAG Repeat Length Mutation in Huntington`s Disease SRM 2365 - BK Virus DNA Quantitative Standard SRM 2366a - Cytomegalovirus DNA (Towne Δ147 BAC) for DNA SRM 2367 - JC
Photograph of a unit of SRM 3950 showing a labeled box and two frost covered amber bottles.

Clinical Measurements Quality Assurance Program

Ongoing
The National Institute of Standards and Technology (NIST) established the Clinical Measurements Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. Participants measure concentrations of marker compounds, contaminants, metabolites in clinical samples (e.g

Combinatorial Approaches to Thin Film Nanomaterials

Completed
The behavior and performance of nanostructured materials and devices are governed by the chemistry and structure of their surfaces and interfaces. However, chemistry-structure-performance relationships in these systems are complex, so hundreds of experiments can be necessary to determine optimal