Analytical chemistry

News and Updates

Two New Reference Materials Assist Supplement Makers with Measurements of Isoflavones in Kudzu

August 3, 2021

Kudzu, a member of the pea family native to East Asia and considered an invasive weed in the American South, has been used for centuries in Chinese medicine and

NIST Researchers Use Novel Method to Understand the Molecular Underpinnings of a Tumorlike Disease Affecting Coral Reefs

July 9, 2021

Coral reefs are a favorite spot for scuba divers and are among the world’s most diverse ecosystems. For example, the Hawaiian coral reefs, known as the

NIST, Collaborators Develop New Method to Better Study Microscopic Plastics in the Ocean

May 20, 2021

If you’ve been to your local beach, you may have noticed the wind tossing around litter such as an empty potato chip bag or a plastic straw. These plastics

Projects and Programs

NCNR DAC and CCUS efforts

Overview Capture of carbon dioxide from the air (direct air capture; DAC) combined with energy efficiency and carbon capture, utilization and storage (CCUS)

NIST Tools for Cannabis Laboratory Quality Assurance

The Chemical Sciences Division (CSD) at NIST is developing an integrated measurement services program for Forensic and Cannabis (hemp and marijuana)

Far-infrared Spectroscopy of Biomolecules (Archived)

Far-infrared (or terahertz/THz, ca. 25 to 300 micron wavelength) femtosecond pulsed laser and Fourier-transform infrared methods are employed to measure

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

Publications

Experimental confirmation of long hyperbolic polariton lifetimes in monoisotopic (10B) hexagonal boron nitride at room temperature

September 14, 2021

Author(s)

Georges Pavlidis, Jeffrey Schwartz, Joseph Matson, Thomas Folland, Song Liu, James Edgar, Joshua Caldwell, Andrea Centrone

Hyperbolic phonon polaritons (HPhPs) enable arbitrarily high confinements, low losses, and directional propagation – providing opportunities from hyperlensing

Total protein quantitation using the bicinchoninic acid (BCA) assay and gradient elution moving boundary electrophoresis (GEMBE)

September 8, 2021

Author(s)

Jason Kralj, Matt S. Munson, David J. Ross

We investigated using gradient elution moving boundary electrophoresis (GEMBE) and capacitively- coupled contactless conductivity detection (C4D) to assay total

Certification of Standard Reference Materials® 2969 and 2970: Vitamin D Metabolites in Frozen Human Serum (Total 25-Hydroxyvitamin D Low Level) and (25-Hydroxyvitamin D2 High Level)

September 2, 2021

Author(s)

Grace Hahm, Michael Nelson, Johanna Camara, Blaza Toman

Standard Reference Materials (SRMs) 2969 and 2970 are intended for 1) use in validating methods for determining concentrations of 25-hydroxyvitamin D2 (25(OH)D2

Interlaboratory Comparison of 25-Hydroxyvitamin D Assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 – Part 1 Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Assays – Impact of 3-epi-25-Hydroxyvitamin D3

August 27, 2021

Author(s)

Stephen Wise, Johanna Camara, Carolyn Burdette, Grace Hahm, Federica Nalin, Adam Kuszak, Joyce Merkel, Ramon Durazo-Arvizu, Emma Walker, Andrew Hoofnagle, Fiona Ivison, Ralf Fischer, Jody van den Ouweland, Chung Ho, Emmet Law, Jean-Nicolas Simard, Renaud Gonthier, Brett Holmquist, Sarah Meadows, Lorna Cox, Kimberly Robyak, Michael Creer, Robert Fitzgerald, Michael Clarke, Norma Breen, Pierre Lukas, Etienne Cavalier, Christopher Sempos

An interlaboratory comparison study was conducted by the Vitamin D Standardization Program (VDSP) to assess the performance of liquid chromatography – tandem

Software

NIST Mass and Fragment Calculator Software

January 31, 2019

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions

NIST DTSA-II

February 1, 2018

NIST DTSA-II builds on the best available algorithms in the literature to simulate, quantify and plan energy dispersive x-ray analysis measurements.

JB95 Spectral fitting program

February 19, 2016

A graphical user interface program, JB95, based on a Windows 95© API platform has been written in the C programming language to aid in the analysis of complex

Simulated Chromatographic Data

The following information is provided as an aid in the validation of mathematical models used in quantitation with chromatographic data. This data may also be

Tools and Instruments

Ozone Standard Reference Photometer

DESCRIPTIONThe Standard Reference Photometer (SRP) Program began in the early 1980s as collaboration between NIST and the U.S. Environmental Protection Agency

Beamline 10: Quantitative Hyperspectral Infrared Microscopy

The new beamline 10, currently under construction, is intended for applications that make use of the super-thermal brightness from SURF in the near- to mid

Atom Probe Tomography (LEAP 4000X Si/HR – Local Electrode Atom Probe)

LEAP 4000X Si/HR Imaging time-of-flight mass spectrometer and field ion microscope. Can deliver 3-D, isotopically- and chemically- resolved images Sub-nanometer

Focused Ion Beam (Helios 660)

The Helios 660 NanoLab(HNL660) is a Focused Ion Beam Scanning Electron Microscope equipped with spectroscopic detectors to allow elemental and phase

Analytical chemistry

News and Updates

Two New Reference Materials Assist Supplement Makers with Measurements of Isoflavones in Kudzu

NIST Researchers Use Novel Method to Understand the Molecular Underpinnings of a Tumorlike Disease Affecting Coral Reefs

NIST, Collaborators Develop New Method to Better Study Microscopic Plastics in the Ocean

Projects and Programs

NCNR DAC and CCUS efforts

NIST Tools for Cannabis Laboratory Quality Assurance

Far-infrared Spectroscopy of Biomolecules (Archived)

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Publications

Experimental confirmation of long hyperbolic polariton lifetimes in monoisotopic (10B) hexagonal boron nitride at room temperature

Total protein quantitation using the bicinchoninic acid (BCA) assay and gradient elution moving boundary electrophoresis (GEMBE)

Certification of Standard Reference Materials® 2969 and 2970: Vitamin D Metabolites in Frozen Human Serum (Total 25-Hydroxyvitamin D Low Level) and (25-Hydroxyvitamin D2 High Level)

Interlaboratory Comparison of 25-Hydroxyvitamin D Assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 – Part 1 Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) Assays – Impact of 3-epi-25-Hydroxyvitamin D3

Software

NIST Mass and Fragment Calculator Software

NIST DTSA-II

JB95 Spectral fitting program

Simulated Chromatographic Data

Tools and Instruments

Ozone Standard Reference Photometer

Beamline 10: Quantitative Hyperspectral Infrared Microscopy

Atom Probe Tomography (LEAP 4000X Si/HR – Local Electrode Atom Probe)

Focused Ion Beam (Helios 660)

Awards

Lane Sander Honored by American Chemical Society

David Long Honored with PECASE

Dr. Tara Lovestead receives highest US government honor for young investigators