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Search Publications by: Young Jong Lee (Fed)

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Displaying 1 - 25 of 39

Single-Detector Double-Beam Modulation for High-Sensitivity Infrared Spectroscopy

October 25, 2023
Seongmin Kim, Yow-Ren Chang, Young Jong Lee
Balanced detection based on double beams is widely used to reduce common-mode noises, such as laser intensity fluctuation and irregular wavelength scanning, in absorption spectroscopy. However, employing an additional detector can increase the total system

Coherent anti-Stokes Raman scattering (CARS) microscopy for polymers

April 1, 2022
Shuyu Xu, Charles Camp, Young Jong Lee
Coherent anti-Stokes Raman scattering (CARS) microscopy is a label-free chemical imaging modality capable of interrogating local molecular composition, concentration, and even orientation. In comparison to traditional Raman spectroscopy/imaging, CARS

Imaging 3D molecular orientation by orthogonal-pair polarization IR microscopy

February 28, 2022
Shuyu Xu, Chad R. Snyder, Jeremy Rowlette, Young Jong Lee
Anisotropic molecular alignment occurs ubiquitously and often heterogeneously in three dimensions (3D). However, conventional imaging approaches based on polarization can map only molecular orientation projected onto the 2D polarization plane. Here, an

Theory of Birefringence Correction for Polarization-Controlled CARS

March 16, 2020
Young J. Lee
Polarization-controlled coherent Raman spectroscopy is used as a high-throughput method to characterize the anisotropic nature of a molecular system, such as the molecular orientation distribution. However, optical birefringence originating from the

Position- and Polarization-Specific Waveguiding of Multi-Emissions in Single ZnO Nanorods

June 19, 2019
Bonghwan Chon, Johnson Truong, Matthew Hansen, Jong-in Hahm, Young Jong Lee
We examine multiphoton-produced optical signals waveguided through single ZnO nanorods (NRs) using a newly developed, scanning offset-emission hyper- spectral microscopy (SOHM) technique. Specifically, we concurrently analyze waveguiding behaviors of sum

Raman Identification of Multiple Melting Peaks of Polyethylene

August 1, 2017
Ying Jin, Anthony P. Kotula, Chad R. Snyder, Angela R. Hight Walker, Kalman D. Migler, Young J. Lee
Multiple melting peaks of high-density polyethylene produced by complex thermal pre-treatment are investigated with variable temperature Raman spectroscopy and differential scanning calorimetry (DSC). We examine the origin of the observed multiple melting

Dielectric Spectroscopy During Extrusion Processing of Polyamide-6 Nanocomposites

February 19, 2017
Rick D. Davis, Anthony J. Bur, Jeffrey W. Gilman, Young Jong Lee, P R. Start
During extrusion processing dielectric spectroscopy was conducted on polyamide-6 (PA6) and organoclay/polyamide-6 nanocomposites. Off-line curve fitting of the on-line dielectric data generated dielectric dispersion parameters that appear sensitive to

Least Squares Moving-Window Spectral Analysis

January 20, 2017
Young J. Lee
Least squares regression is proposed as a moving-windows method for analysis of a series of spectra acquired as a function of external perturbation. The least squares moving-window (LSMW) method can be considered an extended form of the Savitzky–Golay

Beam-Scanning for Rapid Coherent Raman Hyperspectral Imaging

December 14, 2015
Seungwan Ryu, Charles Camp, Ying Jin, Marcus T. Cicerone, Young Jong Lee
Coherent Raman imaging requires high peak power laser pulses to maximize the nonlinear multiphoton signal generation, but accompanying photo-induced sample damage often poses a challenge to microscopic imaging studies. We demonstrate that a beam-scanning

Quantitative, label-free characterization of stem cell differentiation at the single-cell level by broadband coherent anti-Stokes Raman scattering microscopy

December 31, 2014
Marcus T. Cicerone, Young J. Lee, Khaled A. Aamer, Prabhas V. Moghe, Sebastian L. Vega, Parth J. Patel
We use broadband coherent anti-Stokes Raman scattering (BCARS) microscopy to characterize lineage commitment of individual human mesenchymal stem cells (hMSCs) cultured in adipogenic, osteogenic, and basal culture media. We treat hyperspectral images

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues

July 20, 2014
Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone
We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser

Multicomponent Chemical Imaging of Pharmaceutical Solid Dosage Forms with Broadband CARS Microscopy

July 15, 2013
Christopher M. Hartshorn, Marcus T. Cicerone, Young J. Lee, Charles H. Camp, John M. Heddleston, Patrick Marsac, Tim Rhodes, Zhen Liu, Nicole Canfield
We compare broadband coherent anti-Stokes Raman scattering (BCARS) microscopy with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient