Publications

Displaying 26 - 39 of 39

LTB4 IS A SIGNAL RELAY MOLECULE DURING NEUTROPHIL CHEMOTAXIS

May 15, 2012

Author(s)

Philippe V. Afonso, Mirkka Janka-Junttila, Young Jong Lee, Colin P. McCann, Charlotte M. Oliver, Khaled A. Aamer, Wolfgang Losert, Marcus T. Cicerone, Carol A. Parent

Neutrophil recruitment to inflammation sites purportedly depends on sequential waves of chemoattractants. Current models propose that LTB4, a secondary chemoattractant secreted by neutrophils in response to primary chemoattractants such as formyl-peptides

Maximum Entropy and Time-Domain Kramers-Kronig Phase Retrieval Approaches are Functionally Equivalent for CARS Micro-Spectroscopy

April 27, 2012

Author(s)

Marcus T. Cicerone, Khaled A. Aamer, Young J. Lee, Eric Vartiainen

Phase retrieval methods are used to recover Raman spectra from multiplex and broadband CARS signals. Two methods are in widespread use, one based on maximum entropy (MEM), and one based on a modified time-domain Kramers-Kronig (TDKK) method. Here we

Single cell viability measurements in 3D scaffolds using in situ label free imaging by optical coherence microscopy.

December 20, 2011

Author(s)

Joy P. Dunkers, Young J. Lee, Kaushik Chatterjee

The focus on creating tissue engineered constructs of clinically relevant sizes requires new approaches for monitoring construct health during tissue development. A few key requirements are that the technology be in situ, non-invasive, and provide temporal

Quantitative Image Analysis of Broadband CARS Microscopy Hyperspectral Images of Polymer Blends

March 11, 2011

Author(s)

Young Jong Lee, Doyoung Moon, Kalman D. Migler, Marcus T. Cicerone

We demonstrate that broadband coherent anti-Stokes Raman scattering (CARS) microscopy can be very useful for fast acquisition of quantitative chemical images of multilayer polymer blends. Since a raw CARS signal results from coherent interference of

Phonon dephasing and population decay dynamics of the G-band of semiconducting single-wall carbon nanotubes

October 19, 2010

Author(s)

Young Jong Lee, Sapun Parekh, Jeffrey Fagan, Marcus T. Cicerone

The dephasing and population decay dynamics of optical phonons are studied for semiconducting single-wall carbon nanotubes (SWCNTs) using broadband time-resolved coherent anti-Stokes Raman scattering (TR-CARS) and time-resolved incoherent anti-Stokes Raman

Label-free cellular imaging by broadband coherent anti-Stokes Raman scattering microscopy

August 10, 2010

Author(s)

Sapun Parekh, Young J. Lee, Khaled A. Aamer, Marcus T. Cicerone

Raman micro-spectroscopy can provide chemical contrast needed to characterize the complex intracellular environment and macromolecular organization within cells without exogenous labels. It has shown remarkable ability to detect chemical changes underlying

Optimized continuum from a photonic crystal fiber for broadband time-resolved coherent anti-Stokes Raman scattering

February 17, 2010

Author(s)

Young Jong Lee, Sapun Parekh, Yeon Ho Kim, Marcus T. Cicerone

We demonstrate that an optimized 2-pulse broadband coherent anti-Stokes Raman scattering (CARS) technique can be used to simultaneously measure vibrational dephasing times over a broad frequency range of Raman modes (between 500 cm-1 and 3100 cm-1). This

Broadband CARS Spectral Phase Retrieval Using a Time-Domain Kramers-Kronig Transform

April 22, 2009

Author(s)

Yuexin Liu, Young Jong Lee, Marcus T. Cicerone

We describe a closed-form approach for performing a Kramers-Kronig (KK) transform on data of finite frequency range; the method is analytically exact and computationally simple and robust. In this approach we transform the frequency domain data to the time

Pulse shaping for background free broadband CARS

March 16, 2009

Author(s)

Young Jong Lee, Marcus T. Cicerone

We demonstrate that pulse shaping of a probe pulse can suppress the nonresonant background (NRB) contribution and retrieve resonant Raman signal efficiently in broadband coherent anti-Stokes Raman scattering (CARS) spectrum. A pulse shaper prepares a probe

Single-shot interferometric approach to background free broadband coherent anti-Stokes Raman scattering spectroscopy

January 5, 2009

Author(s)

Young Jong Lee, Marcus T. Cicerone

We introduce an interferometric approach to suppress the nonresonant background (NRB) contribution to a broadband coherent anti-Stokes Raman scattering (CARS) spectrum. Single-shot interferometry is conclusive to rapid imaging mode. A pulse shaper prepares

Measuring the Modulus of Hydrated Contact Lenses via Surface Wrinkling

April 6, 2008

Author(s)

Jun Y. Chung, Young Jong Lee, Peyton Hopson, Michael J. Fasolka, Christopher Stafford

One of the most important considerations in the evaluation of hydrogels for biomedical and contact lens applications is the elastic modulus. The elastic modulus relates to several important factors including flexibility, comfort, adhesion, swelling

Vibrational Dephasing Time Imaging by Time-Resolved Broadband Coherent Anti-Stokes Raman Scattering Microscopy

January 28, 2008

Author(s)

Young Jong Lee, Marcus T. Cicerone

Time delay control in broadband coherent anti-Stokes Raman scattering (CARS) allows acquisition of time-resolved CARS images free of non-resonant background (NRB). We demonstrate that, in some cases, CARS image contrast is not chemical contrast, but simply

Characterization of 3-Color CARS in a 2-Pulse Broadband CARS Spectrum

November 15, 2007

Author(s)

Young Jong Lee, Marcus T. Cicerone, Yuexin Liu

We present a new and simple approach to broadband coherent anti-Stokes Raman scattering (CARS) microscopy that yields background-free vibrational spectra. We present evidence for a mechanism where two different frequency components in a continuum pulse

Real-Time Monitoring of Polymer Nanocomposites Composition during Extrusion Compounding

September 1, 2004

Author(s)

Rick D. Davis, Jeffrey W. Gilman, Anthony J. Bur, M M. McBrearty, P R. Start, Young J. Lee

Dielectirc spectroscopy was conducted during extrusion processing of polyamide-6 (PA6) and layered silicate/polyamide-6 manocomposites. Dielectric dispersion parameteers were identified that appear sensitive to layered silicate concentration and degree of

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