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High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues



Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone


We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser sources that probes the Raman spectrum over 3000 cm−1 and generates an especially strong response in the typically weak Raman “fingerprint” region through heterodyne amplification of the anti-Stokes photons with a large nonresonant background (NRB) while maintaining high spectral resolution of
Nature Photonics


broadband coherent anti-Stokes Raman scattering, chemical imaging, coherent anti-Stokes Raman scattering, hyperspectral imaging, label-free


Camp, C. , Lee, Y. , Heddleston, J. , Hartshorn, C. , Hight, A. , Rich, J. , Lathia, J. and Cicerone, M. (2014), High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues, Nature Photonics, [online], (Accessed May 25, 2024)


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Created July 20, 2014, Updated November 10, 2018