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Nancy Lin

Research Interests

  • Microbial cell quantification
  • Quantification of microbial communities including biofilms and microbiomes
  • Biofilm-material interactions
  • Antimicrobial materials and technologies
  • Standards to support biothreat detection and biodefense
  • Biomaterials

Postdoctoral Research Opportunities 

NIST-NRC Postdoctoral Fellowship: Two-year fellowship to work at NIST. Deadlines are Feb. 1 and Aug. 1.  Application requires a 3000-word original research proposal.  Stipend is >$70,000 per year plus benefits and travel funds.  Open to U.S. citizens only. Please contact me if interested in writing a proposal on research related to microbes, biofilms, microbial communities, or antimicrobial biomaterials.  

References (see Publication List)

Peer-reviewed Publications
 

Schultz D, Brinson RG, Sari N, Fagan JA, Bergonzo C, Lin NJ, Dunkers JP. (2019) Structural insights into DNA-stabilized silver clusters. Soft Matter. 2019 May 29;15(21):4284-4293. doi: 10.1039/c9sm00198k.

Lin NJ, Keeler C, Kraigsley AM, Ye J, Lin-Gibson S. (2018) “Effect of dental monomers and initiators on Streptococcus mutans oral biofilms.” Dent Mater, 34(5): 776-785.

Yang Y, Reipa V, Liu G, Meng Y, Wang X, Mineart KP, Prabhu VM, Shi W, Lin NJ, He X, Sun J. (2018) “pH-Sensitive Compounds for Selective Inhibition of Acid-Producing Bacteria.”  ACS Appl Mater Interfaces, 10(10): 8566-8573.

López Pérez D, Baker PJ, Pintar AL, Sun J, Lin NJ, Lin-Gibson S. (2017) “Experimental and statistical methods to evaluate antibacterial activity of a quaternary pyridinium salt on planktonic, biofilm-forming, and biofilm states.” Biofouling, 33(3):222-234.

Lin NJ. (2017) “Biofilm over teeth and restorations: What do we need to know?”  Dent Mater, 33(6):667-680.

Olson ND, Zook JM, Morrow JB, Lin NJ. (2017) “Challenging a bioinformatic tool's ability to detect microbial contaminants using in silico whole genome sequencing data.”  PeerJ, 5:e3729.

Zhang N, Melo MA, Antonucci JA, Lin NJ, Lin-Gibson S, Bai Y, Xu HHK. (2016) “Novel Dental Cement to Combat Biofilms and Reduce Acids for Orthodontic Applications to Avoid Enamel Demineralization.”  Materials (Basel), 9(6): E413.

Chen C, Cheng L, Weir MD, Lin NJ, Lin-Gibson S, Zhou XD, Xu HHK. (2016) “Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks.” Int J Oral Sci, 8(4):239-245.

Da Silva SM, Vang LK, Olson ND, Lund SP, Downey AS, Kelman Z, Salit ML, Lin NJ, Morrow JB. (2016) “Evaluation of microbial qPCR workflows using engineered Saccharomyces cerevisiae,” Biomol Detect Quantif, 7:27-33.

Forry SP, Madonna MC, López-Pérez D, Lin NJ, Pasco MD. (2015) “Automation of antimicrobial activity screening,” AMB Express, 6(1):20-29.

Olson ND, Jackson SA, Lin NJ. (2015) “Report from the Standards for Pathogen Identification via Next-Generation Sequencing (SPIN) Workshop,” Standards in Genomic Sciences, 10: 119.

Williams EH, Davydov AV, Oleshko VP, Steffens KL, Levin I, Lin NJ, Bertness KA, Manocchi AK, Schreifels JA, Rao MV. (2014) “Solution-based functionalization of gallium nitride nanowires for protein sensor development,” Surface Science, 627: 23-28.

Baker BA, Pine PS, Chatterjee K, Kumar G, Lin NJ, McDaniel JH, Salit ML, Simon CG. (2014) “Ontology analysis of global gene expression differences of human bone marrow stromal cells cultured on 3D scaffolds or 2D films,” Biomaterials, 35(25): 6717-6726.

Chen C, Weir MD, Cheng L, Lin NJ, Lin-Gibson S, Chow LC, Zhou X, Xu HHK. (2014) "Antibacterial activity and ion release of bonding agent containing amorphous calcium phosphate nanoparticles," Dental Materials, 30: 891-901.

Waters MS, Kundu S, Lin NJ, Lin-Gibson S. (2014) “Microstructure and mechanical properties of in situ Streptococcus mutans biofilms,” ACS Appl Mater Interfaces, 6(1): 327-332.

Chiang MY, Yangben Y, Lin NJ, Zhong JL, Yang L. (2013) “Relationships among cell morphology, intrinsic cell stiffness and cell-substrate interactions,” Biomaterials, 34(38): 9754-9762.

Zhang K, Cheng L, Imazato S, Antonucci JM, Lin NJ, Lin-Gibson S, Bai Y, Xu HHK. (2013) Effects of dual antibacterial agents MDPB and nano-silver in primer on microcosm biofilm, cytotoxicity and dentin bond properties, Journal of Dentistry, 41(5): 464-474.

Williams EH, Schreifels JA, Rao MV, Davydov AV, Oleshko VP, Lin NJ, Steffens KL, Krylyuk S, Bertness KA, Manocchi AK, Koshka Y. (2012) Selective streptavidin bioconjugation on silicon and silicon carbide nanowires for biosensor applications. Journal of Materials Research, 28(01): 68-77.

Kraigsley AM, Tang K, Lippa KA, Howarter JA, Lin-Gibson S, Lin NJ.  (2012)  Effect of polymer degree of conversion on Streptococcus mutans biofilms. Macromolecular Bioscience, Macromolecular Bioscience, 12(12): 1706-1713.Cheng L, Weir MD, Xu HHK, Antonucci JM, Lin NJ, Lin-Gibson S, Xu SM, Zhou XD.  (2012)  Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms. J Biomed Mater Res B, DOI: 10.1002/jbm.b.32709.

Cheng L, Weir MD, Xu HHK, Antonucci JM, Lin NJ, Lin-Gibson S, Xu SM, Zhou XD.  (2012)  Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms. J Biomed Mater Res B, DOI: 10.1002/jbm.b.32709.

Cheng L, Weir MD, Xu HHK, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. (2012) Antibacterial and physical properties of calcium-phosphate and calcium-fluoride nanocomposites with chlorhexidine. Dental Materials, 28: 573-583.

Cheng L, Weir MD, Xu HHK, Antonucci JM, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. (2012) Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. Dental Materials, 28: 561-572.

Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S, Fowler BO, Lin NJ. (2012) Synthesis and characterization of dimethacrylates containing quaternary ammonium functionalities for dental applications. Dental Materials, 28(2): 219-228.

Fagan JA, Lin NJ, Zeisler R, Hight Walker AR. (2011) Effects of gamma irradiation for sterilization on aqueous dispersions of length sorted carbon nanotubes. Nano Research, 4(4): 393-404.

Moore NM, Lin NJ, Gallant ND, Becker ML. (2011) Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. Acta Biomaterialia, 7(5): 2091-2100.

Cheng YJ, Zeiger DN, Howarter JA, Zhang X, Lin NJ, Antonucci JM, Lin-Gibson S. (2011) In situ formation of silver nanoparticles in photocrosslinking polymers. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 97(1): 124-131.

Sun J, Ding Y, Lin NJ, Zhou J, Ro H, Soles CL, Cicerone MT, Lin-Gibson S. (2010) Exploring cellular contact guidance using gradient nanogratings. Biomacromolecules, 11(11): 3067–3072.

Ding Y, Sun J, Ro HW, Wang Z, Zhou J, Lin NJ, Cicerone MT, Soles CL, Lin-Gibson S. (2011) Thermodynamic underpinnings of cell alignment on controlled topographies. Advanced Materials, 23(3): 421-425.

Cheng YJ, Antonucci JM, Hudson SD, Lin NJ, Zhang X, Lin-Gibson S. (2011) Controlled in situ nanocavitation in polymeric materials. Advanced Materials, 23(3): 409-413.

Moore NM, Lin NJ, Gallant ND, Becker ML. (2010) The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials, 31(7):1604-1611.

Zeiger DN, Stafford CM, Cheng Y, Leigh SD, Lin-Gibson S, Lin NJ.  (2010) Effects of sample preparation on bacterial colonization of polymers. Langmuir, 26(4): 2659-2664.

Lin NJ, Lin-Gibson S. (2009) Osteoblast response to dimethacrylate composites varying in composition, conversion and roughness using a combinatorial approach. Biomaterials, 30(27): 4480-4487.

Sun J, Fang R, Lin NJ, Eidelman N, Lin-Gibson S. (2009) Nondestructive quantification of leakage and its correlation with material performance parameters. Biomaterials, 30(27): 4457-4462.

Lin NJ, Hu HQ, Sung LP, Lin-Gibson S. (2009) Quantification of cell response to polymeric composites using a two-dimensional gradient platform. Combinatorial Chemistry & High Throughput Screening, 12(6): 619-625.

Lin-Gibson S, Sung LP, Forster AM, Hu H, Cheng Y, Lin NJ. (2009) Effects of filler type and content on mechanical properties of photopolymerizable composites measured across two-dimensional combinatorial arrays. Acta Biomaterialia, 5(6): 2084-2094.

Lin NJ, Drzal PL, Lin-Gibson S. (2007) Two-dimensional gradient platforms for rapid assessment of dental polymers: A chemical, mechanical and biological evaluation. Dental Materials, 23(10): 1211-1220.

Lin NJ, Bailey LO, Becker ML, Washburn NR, Henderson LA. (2007) Macrophage response to methacrylate conversion using a gradient approach. Acta Biomaterialia, 3(2): 163-173.

Meilander-Lin NJ, Cheung PJ, Wilson DL, Bellamkonda RV. (2005) Sustained in vivo gene delivery from agarose hydrogel prolongs nonviral gene expression in skin. Tissue Engineering, 11(3-4): 546-555.

Meilander NJ, Pasumarthy MK, Kowalczyk TH, Cooper MJ, Bellamkonda RV. (2003) Sustained release of plasmid DNA from lipid microtubules and agarose hydrogel. Journal of Controlled Release, 88: 321-331.

Meilander NJ, Yu X, Ziats NP, Bellamkonda RV. (2001) Lipid-based microtubular drug delivery systems. Journal of Controlled Release, 71: 141-152.

Book Chapters and Contributions


Jackson S, Lin NJ, Kralj J.  (2018) NIST Special Publication 1222: “Report on the NIST/DHS/FDA Workshop: Standards for Pathogen Detection for Biosurveillance and Clinical Applications, August 14-15, 2017.”

Olson ND, Jackson SA, Lin NJ. (2015) NIST Special Publication 1183: “Standards for Pathogen Identification via Next-Generation Sequencing (SPIN) Workshop Summary Report.”  http://dx.doi.org/10.6028/NIST.SP.1183.

Xu HHK, Cheng L, Zhang K, Melo MS, Weir MD, Antonucci JM, Lin NJ, Lin-Gibson S, Chow LC, Zhou X. (2013) Nanostructured dental composites and adhesives with antibacterial and remineralizing capabilities for caries inhibition. In K. Subramani, et al. (Ed.), Nanobiomaterials in Clinical Dentistry, (pp. 109-129), New York: William Andrew (an Imprint of Elsevier).

Lin NJ, Antonucci JM, Zeiger DN, Tang K, Lin-Gibson S. (2012) Positively-charged dimethacrylates to reduce bacterial attachment. Biomaterials Forum, 34(1): 17-18.

Waters MS, Yang B, Lin NJ, Lin-Gibson S. (2011) Mechanics behind 4D interferometric measurement of biofilm mediated tooth decay. In Tom Proulx (Ed.), Optical Measurements, Modeling, and Metrology, Vol. 5 (pp. 337-344), New York: Springer.

Lin NJ, Sun J, Ding Y, Lin-Gibson S. (2010) Changes in cell orientation due to variations in nanograting height. Biomaterials Forum, 32(4): 31-32.

Meilander NJ, Lee HJ, Bellamkonda RV. (2009) Biomaterials to promote tissue regeneration. In M. Kutz (Ed.), Standard Handbook of Biomedical Engineering and Design, Second Edition, Vol. 1 (pp. 445-477), New York: McGraw-Hill.

Lin-Gibson S, Lin NJ, Landis FA. (2006) High-throughput evaluation of restorative dental polymers. Biomaterials Forum, 28(1): 21-23.

Meilander NJ, Bellamkonda RV. (2004) Lipid microtubules as sustained delivery vehicles for proteins and nucleic acids. In S. Svenson (Ed.), Carrier-based Drug Delivery, ACS Symposium Series 879 (pp. 85-97), WashingtonDC: American Chemical Society.

Meilander NJ , Bellamkonda RV. (2002) Biomaterials to promote tissue regeneration. In M. Kutz (Ed.), Standard Handbook of Biomedical Engineering and Design (pp. 16.1-16.29), New York: McGraw-Hill.

Awards

  • Department of Commerce Bronze Medal Award: “…to increase confidence in biothreat detection,” 2017
  • Department of Commerce Bronze Medal Award: “…for critical evaluation of photo-polymerized dental restoratives,” 2014
  • NIST Safety Award for the BioSafety Working Group, 2012
  • Department of Commerce Bronze Medal Award: “For advancing combinatorial methods…,” 2010
  • National Research Council (NRC/NIST) Postdoctoral Associateship, 2004-2006
  • Graduate Fellowship from The Whitaker Foundation, 1997-2003
  • Graduate Fellowship from the National Science Foundation (declined, 1997)

Publications

Structural Insights into DNA-Stabilized Silver Clusters

Author(s)
Danielle Schultz, Robert G. Brinson, Fahriye N. Sari, Jeffrey A. Fagan, Christina Bergonzo, Nancy J. Lin, Joy P. Dunkers
The structure and dynamics of Ag complexes derived from single stranded DNA (ssDNA) is less understood than their double stranded (dsDNA) counterparts despite
Created July 30, 2019