NIST is collaborating with MedImmune, the biologics research and development arm of AstraZeneca, through a cooperative research and development agreement (CRADA) to determine the genetic stability of Chinese hamster ovary (CHO) cell lines used in the development and commercial production of biopharmaceuticals. Together, we are using STR markers for cell line authentication and microarrays to look for early detection for cell line stability. This information can be used as a tool for screening purposes and to provide insight into high producers of therapeutics.
For technical questions about the Cell Line ID project, please contact Jamie Almeida at jamie.almeida [at] nist.gov (). If your company is interested in authenticating mouse cell lines, please contact Honeyeh Zube at Honeyeh.Zube [at] NIST.gov for license agreement information.