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Fluid Measurements

NIST is meeting the urgent need of numerous industries to measure and control fluids on the scale of microliters and even nanoliters by developing technology that makes possible highly accurate and greatly miniaturized microfluidic devices.

vacuum manifold
Credit: G. Cooksey/NIST
Early experimental setup that enables rapid loading of complex microfluidic devices. It interfaces with a microfluidic chip that has 51 inlets containing 144 chambers and hundreds of embedded pneumatic valves. Due to the speed of connectivity, the manifolds are ideal for rapid prototyping and are well suited to serve as “universal” interfaces.

Many critical processes in medical diagnostics, molecular biology, genetics, pharmaceuticals, biophysics, chemistry, nanotechnology and precision fabrication depend heavily on microfluidics at ever smaller volumes. They demand exacting control and analysis of the properties of a single liquid component (such as drugs, blood or suspended nanoparticles) or of multiple fluids organized into complex networks, typically in arrays of microchannels around tens to hundreds of micrometers wide embedded in blocks of glass or polymers. 

NIST is devising a range of new tools and techniques — often at chip scale — that can ensure high-accuracy flow measurements at the drastically reduced sample sizes and high throughput today’s applications need. Promising projects include development of electrical and photonic sensors as well as novel ways of probing fluids with microwaves and other means. 

In addition, NIST is working to satisfy the growing demand for microfluidic standards traced to a primary reference source, to devise new ways to ensure that results are consistent from device to device and to allow those devices to interconnect with “plug and play” compatibility. None of those conditions exists at present; all are goals of intense NIST research.

Click on the boxes below to explore the technology in more detail. 

Flow and Pressure On-Chip Measurements of Biofluids and Cells

Created November 22, 2019, Updated July 1, 2020