Nanofluidics

News and Updates

NIST Scientists Use DNA Origami on a Chip to Detect Biomolecules

October 17, 2024

Using strands of DNA to create miniature hinges that pop open or shut when binding to specific molecules, researchers at the National Institute of Standards and

NIST Researchers Use Cellphone Compass to Measure Tiny Concentrations of Compounds Important for Human Health

April 1, 2024

Nearly every modern cellphone has a built-in compass, or magnetometer, that detects the direction of Earth’s magnetic field, providing critical information for

The FedTech Startup Studio’s Real-World Approach Advances Technology Transfer

March 22, 2023

Technology Transfer is an intensely dynamic field, and the process of moving federal scientific and technological research from the lab to the marketplace teems

Projects and Programs

viral vector illustration with RNA seen within the capsid

Gene Delivery Particle Analysis with High-Throughput Light Scattering Microscopy

Ongoing

This project aims to develop light-scattering microscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable

Real-Time Tracking and Fluorescence Spectroscopy of Individual Nanoparticles (Archived)

Completed

In liquids, the behavior of a nanoparticle results from a complex interplay of fluid flow, external and internal forces, and random Brownian motion. The goal of this project is to measure the in situ static and dynamic properties of individual nanoparticles in this noisy, fluctuating environment

Advanced Materials Metrology

Ongoing

Electromagnetic devices cannot operate without the interaction of electromagnetic waves with materials, and the characterization of the interface between fields and materials will be a critical task for any device or metrology development from nanoscale to larger scales. Areas of impact over the

Measurements for minimal cells

Ongoing

Minimal cells are cells whose genome has been stripped of all but those genes essential for replication, in a process called "genome minimization." NIST and collaborators demonstrated genome minimization coupled to single cell imaging as a powerful approach to investigate the minimal genetic

Publications

Relaxation times and dynamic behavior of an optofluidic flow meter in the nanoliter per minute regime

February 29, 2024

Author(s)

Nicholas Drachman, Paul Patrone, Gregory A. Cooksey

Accuracy and temporal resolution of flow meters are often unacceptable below the microliter per minute scale, limiting their ability to evaluate the real-time

Letter to the Editor Concerning "Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles"

May 23, 2023

Author(s)

Andrew Madison, Adam L. Pintar, Craig R. Copeland, Natalia Farkas, Samuel M. Stavis

Chromium Oxide – A Novel Sacrificial Layer Material for MEMS/NEMS and Micro/Nanofluidic Device Fabrication

August 1, 2022

Author(s)

Alokik Kanwal, Robert Ilic, Christopher Ray, Kerry Siebein, James Alexander Liddle

Free standing membranes for fluidic devices typically require long etching times due to the slow, diffusion limited exchange of etchant and etch products when

Optofluidic Flow Meter for sub–nanoliter per minute flow measurements

January 31, 2022

Author(s)

Jalal Sadeghi, Paul Patrone, Anthony J. Kearsley, Gregory A. Cooksey

Performance improvements in microfluidic systems depend on accurate measurement and control of fluids on the micro- and nanoscale, and new applications are