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This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins
Recent innovative advances in the design and manufacture of isotope ratio mass spectrometers (IRMS) have revolutionized the study of natural and man-induced
New biological drugs such as peptide drugs, antibody drug conjugates, and vaccines are emerging to fill pharmaceutical voids. They are typically prepared in
To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need
Despite their promise to enable high-throughput science and discovery, microfluidic devices have not yet been broadly adopted. An important missing element in
All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the
Induced pluripotent stem cell (iPSC) populations are complex, dynamic and heterogeneous. Individual cells within a population are constantly changing, while
Confidence in total or viable microbial cell counting methods is lacking, due in part to a dearth of relevant reference materials. NIST has developed a living
Provides services for SI-traceable calibrations of MRI-based biomarkers (such as proton relaxation times, water diffusion and tumor volume), in imaging
Synthetic cell membrane constructs allow the simplification and complete control of a more complicated cellular system, as well as the incorporation of selected
Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such
Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a
All inorganic materials contain point defects in the form of impurities, interstitials, or vacancies. Common imaging techniques fail to capture these defects
NIST is developing microbial measurements to better understand the propagation of antimicrobial resistance (AMR) through a variety of mechanisms. This work
The NIST Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program has been created to demonstrate and improve the comparability of
Evolution poses unique challenges to engineering in living organisms. The successful implementation and development of a sustainable bioeconomy will require
Given the substantial differences between nanoparticles (NPs) and typical organic and inorganic environmental contaminants, new experimental methods and
Accurate measurement of microbial viability is crucial in infectious disease diagnosis and treatment; for development of microbial therapeutics, probiotics and
NIST researchers in the Macromolecular Structure and Function Group are involved in a joint research program with scientists from the University of Maryland
The Cellular Engineering Group works to provide metrology for rapid, successful translation of safe, effective bioproducts based on cell-free expression systems
Advances in methods, instrumentation and standards promote the development of measurement science capabilities in separation technology and physical-chemical