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Displaying 76 - 100 of 134

Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions

December 1, 2009
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D)

NIST Reference Material Scaffolds for Tissue Engineering

December 1, 2009
Author(s)
Carl G. Simon Jr.
The National Institute of Standards and Technology (NIST) has deployed Reference Material (RM) scaffolds for tissue engineering: a series of well-characterized 3D tissue scaffolds with differing porosities (RM 8395, RM 8396 and RM 8397) (Fig. 1). Customers

PEG-HYDROGELS: SYNTHESIS, CHARACTERIZATION, AND CELL ENCAPSULATION

September 15, 2009
Author(s)
Sheng Lin-Gibson, Kaushik Chatterjee, James A. Cooper, William E. Wallace, Matthew Becker, Carl G. Simon Jr., Ferenc Horkay
A simple reaction to prepare controlled molecular mass (MM) poly(ethylene glycol) dimethacrylates (PEGDMs) of high purity and low polydispersity is outlined. PEGDMs were photo-polymerized to form hydrogels with and without bioactive moieties. The structure

Cell Interactions with Biomaterials Gradients and Arrays

August 4, 2009
Author(s)
Yanyin Yang, Vinoy Thomas, Abby W. Morgan, Shauna M. Dorsey, Carl Simon Jr.
Gradients and arrays have become very useful to the fields of tissue engineering and biomaterials.  Both gradients and arrays make efficient platforms for screening cell response to biomaterials.  Graded biomaterials also have functional applications and

Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation

November 15, 2008
Author(s)
Carl G. Simon Jr., Matthew Becker, Sheng Lin-Gibson, Kristen E. Roskov, David L. Kaplan, Abby W. Morgan
This report highlights our recent investigation into -sheet formation and RGD epitope presentation on the surface of blended silk films.1 Surface characterization of biomaterials for tissue engineering applications is of great importance to understand how

Gradient Nanofiber Scaffold Libraries for Tissue Regeneration by Electrospinning

October 15, 2008
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Functional tissue engineering is a rapidly emerging biomedical field that holds great potential for healthcare in addressing the gap between need and availability of donor tissues and organs. The dogma in the field of tissue engineering is to harvest a

X-Ray Imaging Optimization of 3D Tissue Engineering Scaffolds via Combinatorial Fabrication Methods

April 1, 2008
Author(s)
Yanyin Yang, Shauna M. Dorsey, Matthew Becker, Sheng Lin-Gibson, Gary E. Schumacher, Glenn M. Flaim, J Kohn, Carl G. Simon Jr.
We have developed a combinatorial method for determining optimum tissue scaffold composition for imaging by X-ray techniques. X-ray radiography and microcomputed tomography enable non-invasive imaging of implanted materials in vivo and in vitro

Cell Adhesion and Spreading on Poly(D,L-lactic acid) Films Pre-Aged in Cell Medium

January 1, 2008
Author(s)
Ruby I. Chen, Nathan D. Gallant, Jack R. Smith, Matt J. Kipper, Carl G. Simon Jr.
From a biomaterials perspective, three primary events can occur when a biodegradable polymer is implanted in vivo: 1) polymer degradation, 2) protein adsorption to the polymer and 3) swelling of the polymer as it absorbs water. These actions can affect the

Combinatorial Polymer Scaffold Libraries

November 1, 2007
Author(s)
Carl G. Simon Jr., J S. Stephens, Matthew Becker
We have developed a method for fabricating combinatorial libraries of porous, three-dimensional, salt-leached, polymer scaffolds that can be used for screening the effect of scaffold properties on cell response. Syringe pumps, tubing and a static mixer are

Combinatorial Method for Determining Optimum Tissue Scaffold Composition for Imaging by X-Ray Techniques

April 12, 2006
Author(s)
Carl G. Simon Jr., Yanyin Yang, Shauna M. Dorsey, Gary E. Schumacher, Glenn M. Flaim, J Kohn, Sheng Lin-Gibson, Matthew Becker
X-ray imaging techniques can be very useful for tissue engineering applications. The ability to image radiopaque medical implants in vivo with X-ray radiography enables clinicians to conveniently, inexpensively and non-invasively monitor wound healing and

In Vitro Cytotoxicity of Amorphous Calcium Phosphate Composites

May 1, 2005
Author(s)
Carl Simon Jr., Joseph M. Antonucci, D W. Liu, Drago Skrtic
Calcium phosphate-based biomaterials are being widely used as bone substitutes in dentistry as well as reconstructive and orthopedic surgery because of their generally accepted good biocompatibility, osteoconductivity and/or bone-bonding properties. Among
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