Cytotoxicity Evaluation of Three Dimensionally Ordered Macroporous Sol-gel Bioactive Glass (3DOM-BG) Particles

Published

August 1, 2005

Author(s)

K J. Zhang, Brian Washburn, Carl Simon Jr.

Abstract

Sol-gel bioactive glasses (BGs) are a type of third generation biomaterial (i.e., materials that are both bioactive and bioresorbable). Recently, sol-gel bioactive glasses with three dimensionally ordered macroporous structures (3DOM-BGs) were developed by a sol-gel process combined with a colloidal crystal templating method. 3DOM-BGs have been proven to be bioactive (as represented by the bone-like apatite formation) and fully resorbable (as represented by the complete conversion of 3DOM-BG to apatite) in an acellular in vitro model (simulated body fluid). This study continues the research of 3DOM-BGs with an emphasis on their in vitro cellular responses. Wst-1 assay, phase contrast and fluorescence microscopy showed that 3DOM-BG particles are non-cytotoxic and in vitro compatible with osteoblasts.

Citation

Society for Biomaterials

Volume

26 No. 22

Pub Type

Journals

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Keywords

bioglass, biomaterial, calcium phosphate, cell adhesion, cytoxicity

Citation

Zhang, K. , Washburn, B. and Simon Jr., C. (2005), Cytotoxicity Evaluation of Three Dimensionally Ordered Macroporous Sol-gel Bioactive Glass (3DOM-BG) Particles, Society for Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852451 (Accessed October 22, 2025)