Cytotoxicity Evaluation of Three Dimensionally Ordered Macroporous Sol-gel Bioactive Glass (3DOM-BG) Particles
K J. Zhang, Brian Washburn, Carl Simon Jr.
Sol-gel bioactive glasses (BGs) are a type of third generation biomaterial (i.e., materials that are both bioactive and bioresorbable). Recently, sol-gel bioactive glasses with three dimensionally ordered macroporous structures (3DOM-BGs) were developed by a sol-gel process combined with a colloidal crystal templating method. 3DOM-BGs have been proven to be bioactive (as represented by the bone-like apatite formation) and fully resorbable (as represented by the complete conversion of 3DOM-BG to apatite) in an acellular in vitro model (simulated body fluid). This study continues the research of 3DOM-BGs with an emphasis on their in vitro cellular responses. Wst-1 assay, phase contrast and fluorescence microscopy showed that 3DOM-BG particles are non-cytotoxic and in vitro compatible with osteoblasts.
, Washburn, B.
and Simon Jr., C.
Cytotoxicity Evaluation of Three Dimensionally Ordered Macroporous Sol-gel Bioactive Glass (3DOM-BG) Particles, Society for Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852451
(Accessed December 5, 2023)