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Combinatorial Method for Screening the Effect of Nanofiber Scaffold Composition on Cell Response

Published

Author(s)

Murugan Ramalingam, Marian F. Young, Vinoy Thomas, Carl Simon Jr.

Abstract

Statement of Purpose: We are developing combinatorial methods for screening cell-material interactions. Although previous approaches for rapid screening have used material libraries in the form of two-dimensional surfaces or films (2D), biomaterials are commonly used in a three-dimensional scaffold format (3D) and cells behave more physiologically when cultured in a 3D environment. Electrospun nanofibers have shown promise as tissue scaffolds [1] because they mimic the nanotopology of native extracellular matrix (ECM) [2]. Therefore, we are developing a combinatorial platform for screening the effect of nanofiber scaffold composition on cell response.
Proceedings Title
Society for Biomaterials Annual Meeting and Exposition
Conference Dates
April 22-25, 2009
Conference Location
San Antonio, TX, US

Keywords

nanofiber, biomaterial, tissue engineering, hydroxyapatite, poly(e-caprolactone), electrospinning, polymer scaffold

Citation

Ramalingam, M. , Young, M. , Thomas, V. and Simon Jr., C. (2009), Combinatorial Method for Screening the Effect of Nanofiber Scaffold Composition on Cell Response, Society for Biomaterials Annual Meeting and Exposition , San Antonio, TX, US, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=900244 (Accessed April 16, 2024)
Created April 24, 2009, Updated October 12, 2021