Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Combinatorial Polymer Scaffold Libraries



Carl G. Simon Jr., J S. Stephens, Matthew Becker


We have developed a method for fabricating combinatorial libraries of porous, three-dimensional, salt-leached, polymer scaffolds that can be used for screening the effect of scaffold properties on cell response. Syringe pumps, tubing and a static mixer are used to blend polymer solutions which are deposited in a combinatorial fashion as a single graded scaffold or as an array of discrete scaffolds in a 96-well plate. The method is inexpensive to employ requiring only syringe pumps and average lab supplies (polymers, syringes, tubing, solvent, etc.) for implementation. In addition, the approach is versatile since it is amenable to making combinatorial libraries with variations in scaffold composition, scaffold functional group (peptides, reactive groups, bioactive ligands) or scaffold nano-structure (nanoparticles, nanotopography).Both the gradient scaffold libraries and discrete scaffold arrays can serve as a platform to screen cell response to scaffold properties, while the gradient scaffold libraries might also serve as templates for generating functionally graded tissues.
Advanced Materials


cell screening, combinatorial methods, polylactic acid, polymer scaffold


Simon, C. , Stephens, J. and Becker, M. (2007), Combinatorial Polymer Scaffold Libraries, Advanced Materials, [online], (Accessed June 20, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created November 1, 2007, Updated February 19, 2017