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Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D

Published

Author(s)

Yanyin Yang, Matthew Becker, J Kohn, Carl G. Simon Jr.

Abstract

Combinatorial methodology, originated from the drug discovery process, have generated numerous interests in modern materials science in terms of reducing costs of experimentation and accelerating research progress. In developing new biomaterials for tissue engineering applications, most of the combi-high throughput approach is limited to 2-D surfaces or films, contrary to the fact that cells behave physiologically closer to those in vivo if cultured in a 3-D environment. The complex geometry and topography of implant materials also point out the necessity of screening cell-material interactions in 3-D. Hence we have developed an innovate approach, in which osteoblast-like cell responses to 3-D porous scaffolds of 36 discrete compositions were screened at one time.
Citation
Nature Materials

Keywords

biomateirals, cell adhesion, cell proliferation, cell spreading, cell-biomaterial interactions, combinatorial screening, high-throughput screening, polymer scaffolds
Created June 4, 2008, Updated February 19, 2017