Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D



Yanyin Yang, Matthew Becker, J Kohn, Carl G. Simon Jr.


Combinatorial methodology, originated from the drug discovery process, have generated numerous interests in modern materials science in terms of reducing costs of experimentation and accelerating research progress. In developing new biomaterials for tissue engineering applications, most of the combi-high throughput approach is limited to 2-D surfaces or films, contrary to the fact that cells behave physiologically closer to those in vivo if cultured in a 3-D environment. The complex geometry and topography of implant materials also point out the necessity of screening cell-material interactions in 3-D. Hence we have developed an innovate approach, in which osteoblast-like cell responses to 3-D porous scaffolds of 36 discrete compositions were screened at one time.
Nature Materials


biomateirals, cell adhesion, cell proliferation, cell spreading, cell-biomaterial interactions, combinatorial screening, high-throughput screening, polymer scaffolds


Yang, Y. , Becker, M. , Kohn, J. and Simon, C. (2008), Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D, Nature Materials, [online], (Accessed June 14, 2024)


If you have any questions about this publication or are having problems accessing it, please contact

Created June 4, 2008, Updated February 19, 2017