Simon, C.
, Becker, M.
, Lin-Gibson, S.
, Roskov, K.
, Kaplan, D.
and Morgan, A.
(2008),
Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation, Biomaterials Forum, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854450
(Accessed April 26, 2024)
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Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation
Published
Author(s)
, , , Kristen E. Roskov, David L. Kaplan, Abby W. Morgan
Abstract
This report highlights our recent investigation into -sheet formation and RGD epitope presentation on the surface of blended silk films.1 Surface characterization of biomaterials for tissue engineering applications is of great importance to understand how properties drive cellular response. Polymer crystallinity and surface modification with bioactive motifs such as arginine-glycine-aspartate peptide (RGD) alter cell attachment.2,3 In protein-based materials, crystallinity is driven by the transition of -helix to -sheet as is seen in silk.4Citation
Biomaterials Forum
Volume
30
Issue
4
Pub Type
Others
Download Paper
Keywords
Cell adhesion, Cell differentiation, FTIR spectroscopy, Polymer blends, RGD peptide, Silk
Citation
Created November 15, 2008, Updated February 19, 2017