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PUBLICATIONS

Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation

Published

Author(s)

Carl G. Simon Jr., Matthew Becker, Sheng Lin-Gibson, Kristen E. Roskov, David L. Kaplan, Abby W. Morgan

Abstract

This report highlights our recent investigation into -sheet formation and RGD epitope presentation on the surface of blended silk films.1 Surface characterization of biomaterials for tissue engineering applications is of great importance to understand how properties drive cellular response. Polymer crystallinity and surface modification with bioactive motifs such as arginine-glycine-aspartate peptide (RGD) alter cell attachment.2,3 In protein-based materials, crystallinity is driven by the transition of -helix to -sheet as is seen in silk.4
Citation
Biomaterials Forum
Volume
30
Issue
4
Pub Type
Others

Download Paper

Local Download

Keywords

Cell adhesion, Cell differentiation, FTIR spectroscopy, Polymer blends, RGD peptide, Silk
Biomaterials

Citation

Simon, C. , Becker, M. , Lin-Gibson, S. , Roskov, K. , Kaplan, D. and Morgan, A. (2008), Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation, Biomaterials Forum, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854450 (Accessed October 20, 2025)

Issues

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Created November 15, 2008, Updated February 19, 2017
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