Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation

Published

Author(s)

Carl G. Simon Jr., Matthew Becker, Sheng Lin-Gibson, Kristen E. Roskov, David L. Kaplan, Abby W. Morgan

Abstract

This report highlights our recent investigation into -sheet formation and RGD epitope presentation on the surface of blended silk films.1 Surface characterization of biomaterials for tissue engineering applications is of great importance to understand how properties drive cellular response. Polymer crystallinity and surface modification with bioactive motifs such as arginine-glycine-aspartate peptide (RGD) alter cell attachment.2,3 In protein-based materials, crystallinity is driven by the transition of -helix to -sheet as is seen in silk.4
Citation
Biomaterials Forum
Volume
30
Issue
4

Keywords

Cell adhesion, Cell differentiation, FTIR spectroscopy, Polymer blends, RGD peptide, Silk

Citation

Simon, C. , Becker, M. , Lin-Gibson, S. , Roskov, K. , Kaplan, D. and Morgan, A. (2008), Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation, Biomaterials Forum, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=854450 (Accessed May 28, 2024)

Issues

If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.

Created November 15, 2008, Updated February 19, 2017