Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D) structural and compositional features of native extracellular matrix. Screening the effect of scaffold compositions and properties that optimize tissue regeneration is the key for the selection of scaffolds for use in tissue engineering. Although previous approaches for rapid screening have used biomaterial libraries in the form of two-dimensional (2D) surfaces or films, biomaterials are commonly used in a 3D scaffold format and cells behave more physiologically when cultured in a 3D environment. Therefore, we report on a new combinatorial electrospinning technique for the production of well-defined continuous gradient nanofiber scaffold libraries suitable for rapid screening cellular responses such as adhesion, proliferation and differentiation that optimize tissue regeneration.
, Ramalingam, M.
, Young, M.
and Thomas, V.
Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions, European Society for Biomaterials 2009, Lausanne, -1, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=901837
(Accessed December 10, 2023)