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Nanotechnology

Nanobiotechnology

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  • Published Date
Displaying 101 - 125 of 141

Quantifying Dithiothreitol Displacement of Functional Ligands from Gold Nanoparticles

October 27, 2012
Author(s)
De-Hao D. Tsai, Frank W. DelRio, Sherrie R. Elzey, Suvajyoti S. Guha, Michael R. Zachariah, Vincent A. Hackley, Melanie P. Shelton
Dithiothreitol (DTT)-based displacement is widely utilized for separating ligands from their gold nanoparticle (AuNP) conjugates, a critical step for differentiating and quantifying surface-bound functional ligands and therefore the effective surface

PEG-Labeled Nucleotides and Nanopore Detection for Single Molecule DNA Sequencing by Synthesis

September 21, 2012
Author(s)
Shiv Kumar, Tao Chuanjuan, Chien Minchen, Hellner Brittney, Joseph W. Robertson, Arvind Balijepalli, Li Zengmin, James J. Russo, Joseph E. Reiner, John J. Kasianowicz, Jingyue Ju
There is a significant need to accurately sequence single DNA and RNA molecules for personalized medicine. We describe a novel nanopore-based sequencing by synthesis (SBS) strategy that will accurately differentiate at single molecule level four different

Disentangling the effects of polymer coatings on silver nanoparticle agglomeration, dissolution, and toxicity to determine mechanisms of nanotoxicity

September 1, 2012
Author(s)
Justin M. Zook, Melissa D. Halter, Danielle Cleveland, Stephen E. Long
Silver nanoparticles (AgNPs) are frequently coated by a variety of polymers, which may affect various intertwined mechanisms of toxicity, including agglomeration and dissolution rate. Here, we measure how citrate, dextran, poly(ethylene glycol) (PEG)

A Lectin-Based Gold Nanoparticle Assay for Probing Glycosylation of Glycoproteins

April 17, 2012
Author(s)
Germarie Sanchez-Pomales, Todd A. Morris, James Falabella, Michael J. Tarlov, Rebecca A. Zangmeister
We report a glycoanalysis method in which lectins are used to probe the glycans of glycoproteins that are adsorbed on gold nanoparticles. A model mannose-presenting glycoprotein, ribonuclease B (RNase B), and the therapeutic monoclonal antibody (mAb)

Tumor Necrosis Factor Interaction with Gold Nanoparticles

March 14, 2012
Author(s)
De-Hao D. Tsai, Sherrie R. Elzey, Frank W. DelRio, Robert I. MacCuspie, Suvajyoti S. Guha, Michael R. Zachariah, Athena M. Keene, Jeffrey D. Clogston, Vincent A. Hackley
We report on a systematic investigation of molecular conjugation of tumor necrosis factor protein-α (TNF) onto gold nanoparticles (AuNPs) and the subsequent binding behavior to its antibody (anti-TNF). We employ a combination of physical and spectroscopic

Through-focus Scanning Optical Microscopy

December 31, 2011
Author(s)
Ravikiran Attota
Through-focus scanning optical microscopy (TSOM) method provides three-dimensional information (i.e. the size, shape and location) about micro- and nanometer-scale structures. TSOM, based on a conventional optical microscope, achieves this by acquiring and

Nanometrology Using Through-Focus Scanning Optical Microscopy Method

December 21, 2011
Author(s)
Ravikiran Attota, Richard M. Silver
We present an initial review of a novel through-focus scanning optical microscopy (TSOM) imaging method that produces nanometer dimensional measurement sensitivity using a conventional bright-field optical microscope. In the TSOM method a target is scanned

TSOM Method for Nanoelectronics Dimensional Metrology

November 18, 2011
Author(s)
Ravikiran Attota
Through-focus scanning optical microscopy (TSOM) is a relatively new method that transforms conventional optical microscopes into truly three-dimensional metrology tools for nanoscale to microscale dimensional analysis. TSOM achieves this by acquiring and

SEM Induced Shrinking of Solid State Nanopores for Single Molecule Detection

September 22, 2011
Author(s)
Anmiv Prahbu, Kevin J. Freedman, Joseph W. Robertson, Zhorro Nikolov, John J. Kasianowicz, MinJun Kim
We have investigated the shrinkage of solid state nanopores by a scanning electron microscope and find the process to be reproducible and dependant beam parameters such as the accelerating voltage and electron flux. The shrinking phenomenon does not

Quantitative Determination of Competitive Molecular Adsorption on Gold Nanoparticles Using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy

June 28, 2011
Author(s)
De-Hao D. Tsai, Melissa Davila-Morris, Frank W. DelRio, Suvajyoti S. Guha, Vincent A. Hackley, Michael R. Zachariah
Surface-sensitive quantitative studies of competitive molecular adsorption on nanoparticles were conducted using a modified Attenuated attenuated Total total Reflectionreflectance-Fourier Transform transform Infrared infrared (ATR-FTIR) spectroscopy method

PDH-locked, frequency-stabilized cavity ring-down spectrometer

June 16, 2011
Author(s)
Joseph T. Hodges, A. Cygan, Piotr Maslowski, Katarzyna E. Bielska, S. Wojtewicz, J. Domyslawska, Hisashi Abe, R.S. Trawinski, R. Ciurylo
We describe a high sensitivity and high spectral resolution laser absorption spectrometer based upon the frequency-stabilized cavity ring-down spectroscopy (FS-CRDS) technique. We used the Pound-Drever-Hall (PDH) method to lock the probe laser to the high

TSOM Method for Semiconductor Metrology

April 18, 2011
Author(s)
Ravikiran Attota, Ronald G. Dixson, John A. Kramar, James E. Potzick, Andras Vladar, Benjamin D. Bunday, Erik Novak, Andrew C. Rudack
Through-focus scanning optical microscopy (TSOM) is a new metrology method that achieves 3D nanoscale measurement resolution using conventional optical microscopes; measurement sensitivities are comparable to what is typical using Scatterometry, SEM and

Quantification and Compensation of Unintentional Analyte Aggregation in Electrospray Sampling

March 30, 2011
Author(s)
Mingdong M. Li, Suvajyoti S. Guha, Rebecca A. Zangmeister, Michael J. Tarlov, Michael R. Zachariah
Electrospray (ES) sources are commonly used to introduce non-volatile materials (e.g. nanoparticles, proteins, etc.) in to the gas phase for characterization by mass spectrometry and ion mobility. Recent studies in our group using electrospray ion mobility

Electrochemical measurement of diffusion in photopolymerized polyethylene glycol (PEG) hydrogels

October 29, 2010
Author(s)
Kavita M. Jeerage, Stephanie M. LaNasa, Holly A. Hughes, Damian S. Lauria, Stephanie J. Bryant, Andrew J. Slifka
Scanning electrochemical microscopy has been used to examine the molecular transport properties of photopolymerized poly(ethylene glycol) (PEG) hydrogels having different mesh sizes. Both the molecular weight (508 Da or 3000 Da) of the PEG diacrylate

Microfabricated High-Moment Micrometer-Sized MRI Contrast Agents

August 26, 2010
Author(s)
Gary Zabow, John M. Moreland, Stephen Dodd, alan koretsky, erik shapiro
While chemically synthesized superparamagnetic microparticles have enabled much new research based on MRI tracking of magnetically labeled cells, signal-to-noise levels still limit the potential range of applications. Here it is shown how, through top-down

Nanoparticle size and shape evaluation using the TSOM optical microscopy method

June 6, 2010
Author(s)
Ravikiran Attota, Richard J. Kasica, Lei Chen, Premsagar P. Kavuri, Richard M. Silver, Andras Vladar
We present a novel optical TSOM (through-focus scanning optical microscopy - pronounced as 'tee-som') method that produces nanoscale dimensional measurement sensitivity using a conventional optical microscope. The TSOM method uses optical information from

Theory for Polymer Analysis Using Nanopore-based Single-molecule Mass Spectrometry

June 1, 2010
Author(s)
Joseph E. Reiner, John J. Kasianowicz, Brian J. Nablo, Joseph W. Robertson
Nanometer-scale pores have demonstrated potential as a tool for the electrical detection and characterization of molecules. To provide a physical basis for nanopore-based analytical metrology, we show that a simple model quantitatively describes how one
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