Nanobiotechnology

News and Updates

Sneezes, Rain Clouds and Ink Jets: NIST Improves the Ability of Optical Microscopes to Measure the Volume of Microdroplets

December 20, 2021

Sneezes, rain clouds, and ink jet printers: They all produce or contain liquid droplets so tiny it would take several billion of them to fill a liter bottle

A woman (Diane Nelson) in a mask and lab coat works with plastic test tubes at a lab bench.

Spotlight: Taking a Closer Look at Human Lungs With Postdoctoral Researcher Diane Nelson

December 9, 2021

A breath of fresh air — Diane Nelson recently joined NIST as a postdoctoral researcher, open to opportunities and committed to her craft. The inner workings of

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

Projects and Programs

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Ongoing

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

Measurements for minimal cells

Ongoing

Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a

Molecular Physiology

Ongoing

The natural world is a magnificent place with observable, via measurement and inference, physical structures spanning at least 43 orders of magnitude in space

Schematic showing DNA origami in a laser beam

DNA Origami for Precise Manufacturing of Nanoscale Structures

Completed

Over the past decade nanoscale science has produced varied and fascinating nanostructures with an extraordinary range of interesting and useful properties. In

Publications

A guide to nanoscale IR spectroscopy: resonance enhanced transduction in contact and tapping mode AFM-IR

May 26, 2022

Author(s)

Jeffrey Schwartz, Devon Jakob, Andrea Centrone

Infrared (IR) spectroscopy is a broadly applicable, composition sensitive analytical technique. By leveraging the high spatial resolution of atomic force

High Throughput Synthesis and Characterization of Next-Generation Lipid Nanoparticles for Enhanced In Vivo Performance

March 3, 2022

Author(s)

Bryant C. Nelson, Sven Even Borgos

Addressable graphene encapsulation of wet specimens on a chip for optical, electron, infrared and X-ray based spectromicroscopy studies

October 15, 2021

Author(s)

Andrei Kolmakov

Label-free spectromicroscopy methods offer the capability to examine complex cellular phenomena. Electron and X-ray based spectromicroscopy methods, though

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021

Author(s)

Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch

Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and