Nanobiotechnology

News and Updates

nucleic acid nanotechnology illustration

A Revolution Still in the Making: NIST Researchers Chart the Future of Nucleic Acid Nanotechnology

October 27, 2022

Trapped in a microscopic cage made of strands of DNA, molecules of a life-saving drug course through the bloodstream of a cancer patient. Only when receptors on

Sneezes, Rain Clouds and Ink Jets: NIST Improves the Ability of Optical Microscopes to Measure the Volume of Microdroplets

December 20, 2021

Sneezes, rain clouds, and ink jet printers: They all produce or contain liquid droplets so tiny it would take several billion of them to fill a liter bottle

A woman (Diane Nelson) in a mask and lab coat works with plastic test tubes at a lab bench.

Spotlight: Taking a Closer Look at Human Lungs With Postdoctoral Researcher Diane Nelson

December 9, 2021

A breath of fresh air — Diane Nelson recently joined NIST as a postdoctoral researcher, open to opportunities and committed to her craft. The inner workings of

Projects and Programs

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Ongoing

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

Video microscopic image - Rotation and translation.

Control of Magnetic Nanoparticles for Nanoscale Manipulation of Fluids and Materials (Archived)

Completed

Scientists and engineers currently have a growing library of synthetic microscale and nanoscale swimmers which affect the hydrodynamics of their surroundings in

Controlling Microfluidic Cell Cultures

Ongoing

NIST has taken advantage of recent technological advances to develop polymer microfluidic cell culture systems that provide a level of control over the cellular

Nanometrology: Composition and Structure of Nanomaterials

Ongoing

Advances in methods, instrumentation and analysis protocols are developed to enhance measurement science capabilities in nanomaterial elemental and

Publications

Polyethyleneimine/polyethylene glycol–conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: Testing in frog embryo teratogenesis assay–Xenopus and mammalian tissue culture system

March 15, 2023

Author(s)

Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C. Nelson, David A. LaVan, Vincent A. Hackley, Tae Joon Cho

Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis

Orthogonal and complementary measurements of properties of drug products containing nanomaterials

January 6, 2023

Author(s)

Bryant C. Nelson, Elijah Petersen, Carl Simon Jr., Sven-Even Borgos, Luigi Calzolai, Jeremie Parot, Matthias Roesslein, Fanny Caputo, Xiaoming Xu

Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical

Synthesizing the biochemical and semiconductor worlds: the future of nucleic acid nanotechnology

October 13, 2022

Author(s)

Jacob Majikes, James Alexander Liddle

There are few phrases truer for technological soothsaying than "fools rush in where angels fear to tread." Prediction is particularly difficult in the case of

Best practice for improved accuracy: A critical reassessment of van't Hoff analysis of melt curves

June 7, 2022

Author(s)

Jacob Majikes, Michael Zwolak, James Alexander Liddle

Biomolecular, particularly DNA, thermodynamics are frequently determined via van't Hoff analysis of optically-measured melt curves. The popularity of this