Nanobiotechnology

News and Updates

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

A new twist on measuring spin: NIST Develops Microresonator to Study Electron Spin in Small Volumes

November 17, 2020

Researchers at the National Institute of Standards and Technology (NIST) have developed a device to detect a quantum property of electrons, known as spin, in

NIST Scientists Get Soft on 3D Printing

September 22, 2020

Researchers at the National Institute of Standards and Technology (NIST) have developed a new method of 3D-printing gels and other soft materials. Published in

Projects and Programs

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

Schematic showing DNA origami in a laser beam

DNA Origami for Precise Manufacturing of Nanoscale Structures

Over the past decade nanoscale science has produced varied and fascinating nanostructures with an extraordinary range of interesting and useful properties. In

Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA

We utilized isotope-dilution liquid chromatography/mass spectrometry (LC/MS) to determine the levels of the oxidatively damaged DNA bases, 8

Metrologies for Nanobiomaterials in Artificial Photosynthesis

Novel technologies for solar fuel production are expected to increasingly contribute to meeting our nation's environmental and energy needs. Mimicking nature's

Publications

Failure mechanisms in DNA self-assembly: Barriers to single fold yield

February 23, 2021

Author(s)

Jacob M. Majikes, Paul N. Patrone, Anthony J. Kearsley, Michael P. Zwolak, James A. Liddle

Understanding the folding process of DNA origami is a critical steppingstone to the broader implementation of nucleic acid nanofabrication technology but is

DNA Origami Design: A How-To Tutorial

January 8, 2021

Author(s)

Jacob M. Majikes, James A. Liddle

While the design and assembly of DNA origami are straightforward, its relative novelty as a nanofabrication technique means that the tools and methods for

Analysis and Uncertainty Quantification of DNA Fluorescence Melt Data: Applications of Affine Transformations

October 15, 2020

Author(s)

Paul N. Patrone, Anthony J. Kearsley, Jacob M. Majikes, James A. Liddle

Revealing thermodynamics of DNA origami folding via affine transformations

June 4, 2020

Author(s)

Jacob M. Majikes, Paul N. Patrone, Daniel R. Schiffels, Michael P. Zwolak, Anthony J. Kearsley, Samuel P. Forry, James A. Liddle

Structural DNA nanotechnology, as exemplified by DNA origami, has enabled the design and construction of molecularly precise objects for a myriad of