Nanobiotechnology

News and Updates

Sneezes, Rain Clouds and Ink Jets: NIST Improves the Ability of Optical Microscopes to Measure the Volume of Microdroplets

December 20, 2021

Sneezes, rain clouds, and ink jet printers: They all produce or contain liquid droplets so tiny it would take several billion of them to fill a liter bottle

A woman (Diane Nelson) in a mask and lab coat works with plastic test tubes at a lab bench.

Spotlight: Taking a Closer Look at Human Lungs With Postdoctoral Researcher Diane Nelson

December 9, 2021

A breath of fresh air — Diane Nelson recently joined NIST as a postdoctoral researcher, open to opportunities and committed to her craft. The inner workings of

NIST Publishes a Beginner’s Guide to DNA Origami

January 8, 2021

In a technique known as DNA origami, researchers fold long strands of DNA over and over again to construct a variety of tiny 3D structures, including miniature

Projects and Programs

PTIR combines the spatial resolution of AFM with the specificity of absorption spectroscopy

Nano-Chemical Imaging and -Spectroscopy (IR, nIR, VIS)

Ongoing

Conventional techniques for analyzing chemical composition, such as infrared (IR) microscopy often miss critically important nanoscale details. To overcome this

Nano-biophotonics for molecular imaging

Ongoing

Biophotonics is at the intersection of photonics and biology where light is used to image, detect, and manipulate biological materials. This project addresses

A micromechanical bulk acoustic resonator that uses phononic crystal tethers to achieve a quality factor approaching the fundamental dissipation limit (fxQ can be as large as 1.2 x 1013 Hz)

Micro- and Nanoelectromechanical Systems

Ongoing

Microelectromechanical systems (MEMS) are integrated devices with critical applications in sensing, timing, signal processing, and biomedical diagnostics, and

Measurements for minimal cells

Ongoing

Technologies to manipulate biological systems have far outpaced our ability to design the function of those systems in a predictable way. This is, in part, a

Publications

High Throughput Synthesis and Characterization of Next-Generation Lipid Nanoparticles for Enhanced In Vivo Performance

March 3, 2022

Author(s)

Bryant C. Nelson, Sven Even Borgos

Addressable graphene encapsulation of wet specimens on a chip for optical, electron, infrared and X-ray based spectromicroscopy studies

October 15, 2021

Author(s)

Andrei Kolmakov

Label-free spectromicroscopy methods offer the capability to examine complex cellular phenomena. Electron and X-ray based spectromicroscopy methods, though

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021

Author(s)

Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch

Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and

Critical considerations for the design of multi-organ microphysiological systems (MPS)

September 9, 2021

Author(s)

Mridu Malik, Yang Yang, Parinaz Fathi, Gretchen Mahler, Mandy Esch

The process of identifying new drugs and getting them approved for use in patients requires extensive preclinical studies and clinical trials. Preclinical