Nano-biophotonics consists of four broad areas: molecular bioimaging; nano-biosensors; multiplexed bioassays; and nanotechnology-based medical practices for diagnosis and therapy. Success in these areas is challenged by the underlying complexity of biological systems. Major levels of complexity and associated technical barriers appear at all levels of biology including the molecular, cellular, and tissue and organism levels. To address these challenges, our research strategies are based on the following approaches.
- Molecular level: we are developing optical measurement tools to study biomechanics of intra- and inter-molecular interactions and interactions between organic molecules and nanomaterials in a controlled environment in support of quantitative use of nanomaterials and novel probes in biology and medicine.
- Cellular level: we are developing optical measurement techniques to investigate molecular interactions and processes in single cells andsingle cell-based optical techniques, standards, and validation assays in support of cell-based disease diagnostics.
- Tissue and organism level: we are developing integrated molecular optical imaging techniques for optical diagnostics of tissues and organisms in support of standardized optical medical imaging in clinic.