The main research theme is the design and implementation of novel surface functionalities on engineered nanomaterials, by chemical approach, for biological applications. This project involves (1) the creation of biocompatible nanomaterial systems as drug delivery templates, (2) characterization of physico-chemical properties, (3) assessing colloidal stability study under various conditions (physiological circumstances), (4) discovery of bioactivity (e.g. toxicity, release of drug moiety, etc.) and metabolism (interaction with bio entities inside body) mechanisms, in accordance with (5) measurement method development for qualification/quantification of functionalities, and (6) enhancement of manufacturing efficiency through methodological studies for the particular nanomaterials. For successful achievement of this project, our team is establishing collaborations internally at NIST, with other federal entities and/or academia (in US and overseas) to conduct insightful studies. Long-term goals involve development of a program for ‘Design and recognition of bioactive nanomaterials as nanomedicines’ which will include (a) invention, (b) metrology development for discovery of physico-chem-biological behaviors, and (c) manufacturing.
Tae Joon Cho, et. al, “Unexpected Changes in Functionality and Surface Coverage for Au Nanoparticle PEI Conjugates: Implications for Stability and Efficacy in Biological Systems”, Langmuir, 31, 7673−7683 (2015)
Jiaojie Tan, Tae Joon Cho, et. al, “Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release”, Langmuir, 34, 154−163 (2018)