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Development of surface functionalized engineered nanomaterials for biological applications

Summary

The main research theme is the design and implementation of novel surface functionalities on engineered nanomaterials, by chemical approach, for their biological applications. This project would contain (1) the creation of biocompatible nanomaterial systems as drug delivery templates, (2) characterization of physico-chemical properties, (3) colloidal stability study under various conditions (physiological circumstances), (4) discovery of bioactivity (e.g. toxicity, release of drug moiety, etc.) and metabolism (interaction with bio entities inside body) mechanisms, in accordance with (5) metrology development for qualification/quantification of functionalities, and (6) enhancement of manufacturing efficiency through methodological studies for the particular nanomaterials. For successful achievement of this project, our team would establish collaboration system with internal NIST, with federal agencies and/or academia (in US and overseas) to conduct insightful studies with specific expertise as demanded. Also, as the other critical feature, this project can contribute to development of nano-related instruments by providing model nanomaterials for evaluation of detection capability. Substantial contribution is expected founding the long-term program for ‘Design and recognition of bioactive nanomaterials as nanomedicines’ which will include (a) Invention, (b) metrology development for discovery of physico-chem-biological behaviors, and (c) manufacturing.

Description

The main research theme is the design and implementation of novel surface functionalities on engineered nanomaterials, by chemical approach, for biological applications. This project involves (1) the creation of biocompatible nanomaterial systems as drug delivery templates, (2) characterization of physico-chemical properties, (3) assessing colloidal stability study under various conditions (physiological circumstances), (4) discovery of bioactivity (e.g. toxicity, release of drug moiety, etc.) and metabolism (interaction with bio entities inside body) mechanisms, in accordance with (5) measurement method development for qualification/quantification of functionalities, and (6) enhancement of manufacturing efficiency through methodological studies for the particular nanomaterials. For successful achievement of this project, our team is establishing collaborations internally at NIST, with other federal entities and/or academia (in US and overseas) to conduct insightful studies.  Long-term goals involve development of a program for ‘Design and recognition of bioactive nanomaterials as nanomedicines’ which will include (a) invention, (b) metrology development for discovery of physico-chem-biological behaviors, and (c) manufacturing.

Example Studies

 

 

Au-Pt
Cartoon depiction of conjugation and complexation steps in processing of AuNP-(dendron), AuNP-(dendron)-(SH-PEG) and cisplatin (PtII) complexed products.

Jiaojie Tan, Tae Joon Cho, et. al, “Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release”, Langmuir, 34, 154−163 (2018)

graphical abstract processing nanoparticles
Graphical Abstract: Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications

Tae Joon Cho et. al, “Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications: Part 1. A critical assessment of methodology, properties, and stability”, Journal of Nanoparticle Research, 21:188, (2019)

Created March 28, 2018, Updated August 27, 2020