Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

SEM Induced Shrinking of Solid State Nanopores for Single Molecule Detection



Anmiv Prahbu, Kevin J. Freedman, Joseph W. Robertson, Zhorro Nikolov, John J. Kasianowicz, MinJun Kim


We have investigated the shrinkage of solid state nanopores by a scanning electron microscope and find the process to be reproducible and dependant beam parameters such as the accelerating voltage and electron flux. The shrinking phenomenon does not involve simple electron beam induced deposition of hydrocarbon contaminants but is an energy dependant process that involves material flow along the surface of the nanopore membrane. Pores thus fabricated were then used to detect λ DNA.
Nano Letters


nanopore, scanning electron microscopy, nanolithography, DNA, single molecule sensing


Prahbu, A. , Freedman, K. , Robertson, J. , Nikolov, Z. , Kasianowicz, J. and Kim, M. (2011), SEM Induced Shrinking of Solid State Nanopores for Single Molecule Detection, Nano Letters, [online], (Accessed April 20, 2024)
Created September 21, 2011, Updated October 12, 2021