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Nanotechnology

Nanobiotechnology

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  • Published Date
Displaying 76 - 100 of 141

Multifocus microscopy with precise color multi-phase diffractive optics applied in functional neuronal imaging

March 1, 2016
Author(s)
Sara Abrahamsson, Robert Ilic, Jan Wisniewski, Brian Mehl, Liya Yu, Lei Chen, Marcelo I. Davanco, Laura Oudjedi, Jean Bernard Fiche, Bassam Hajj, Xin Jin, Joan Pulupa, Christine Cho, Mustafa Mir, Mohamed El Beheiry, Xavier Darzacq, Marcelo Nollmann, Maxime Dahan, Carl Wu, Timothee Lionnett, James Alexander Liddle, Cornelia Bargmann
Multifocus microscopy (MFM) allows high-resolution instantaneous three-dimensional (3D) imaging and has been applied to study biological specimens ranging from single molecules inside cell nuclei to entire embryos. In any live microscopy application

Handheld Real-Time PCR Device

January 26, 2016
Author(s)
Christian D. Ahrberg, Robert Ilic, Andreas Manz, Pavel Neu?il
Here we report one of the smallest real-time PCR system up to date with approximate size of 100 mm × 60 mm × 33 mm. The system is an autonomous unit requiring an external 12 V power supply. Four simultaneous reactions are performed in form of virtual

Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing

December 23, 2015
Author(s)
Eugene Paulechka, Tsjerk A. Wassenaar, Kenneth Kroenlein, Andrei Kazakov, Alexander Smolyanitsky
We propose a water-immersed nucleobase-functionalized suspended graphene nanoribbon as an intrinsically selective device for nucleotide detection. The proposed sensing method combines Watson–Crick selective base pairing with graphene's capacity for

Orthogonal Analysis of Functional Gold Nanoparticles for Biomedical Applications

September 11, 2015
Author(s)
De-Hao D. Tsai, Yi-Fu Lu, Frank W. DelRio, Tae Joon Cho, Suvajyoti S. Guha, Michael R. Zachariah, Fan Zhang, Andrew J. Allen, Vincent A. Hackley
We report a comprehensive strategy based on implementation of orthogonal measurement techniques to provide critical and verifiable material characteristics for functionalized gold nanoparticles (AuNPs) used in biomedical applications. Thiolated

Microfluidic Remote Loading for Rapid Single-Step Liposomal Drug Preparation

July 29, 2014
Author(s)
Wyatt N. Vreeland, Renee R. Hood, Don L. DeVoe
Here we report a microfluidic system that enables rapid and efficient remote loading of amphipathic drugs into nanoscale liposomes, combining liposome synthesis and remote drug loading in a continuous integrated process. Unlike established bulk methods for

A Facile Route to the Synthesis of Monodisperse Nanoscale Liposomes Using 3D Microfluidic Hydrodynamic Focusing in a Concentric Capillary Array

May 14, 2014
Author(s)
Wyatt N. Vreeland, Renee R. Hood, Don L. DeVoe, Francisco J. Atencia, Donna M. Omiatek
A novel microscale device has been developed to enable the one-step continuous flow assembly of monodisperse nanoscale liposomes using three-dimensional microfluidic hydrodynamic focusing (3D-MHF) in a radially symmetric capillary array. The 3D-MHF flow

N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes

April 1, 2014
Author(s)
Navin C. Sabharwal, Victoria Savikhin, Joshua Turek-Herman, John M. Nicoludis, Veronika Szalai, Liliya Yatsunyk
Guanine quadruplexes (GQ) are four-stranded DNA structures formed by guanine-rich DNA sequences. Formation of GQs inhibits cancer cell survival, but detecting GQs in vivo has proved difficult, in part because of GQ structural diversity. Development of GQ

Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport

March 21, 2014
Author(s)
Wyatt N. Vreeland, Renee R. Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado
Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from deeper

Controlled Formation and Characterization of Dithiothreitol-Conjugated Gold Nanoparticle Clusters

March 5, 2014
Author(s)
De-Hao D. Tsai, Tae Joon Cho, Frank W. DelRio, Justin Gorham, Jiwen Zheng, Jiaojie Tan, Michael R. Zachariah, Vincent A. Hackley
We report a systematic study of the controlled formation of discrete-size gold nanoparticle clusters (GNCs) by interaction with the reducing agent dithiothreitol (DTT). Asymmetric-flow field flow fractionation and electrospray differential mobility

Steering Acoustically Propelled Nanowire Motors towards Cells in a Biologically Compatible Environment using Magnetic Fields

December 10, 2013
Author(s)
Suzanne Ahmed, Wei Wang, Lamar O. Mair, Robert D. Fraleigh, Sixing Li, Luz A. Castro, Mauricio Hoyos, Tony J. Huang, Thomas E. Mallouk
The recent discovery of fuel-free propulsion of nanomotors using acoustic energy has provided a new avenue for using nanomotors in biocompatible media. Crucial to the application of nanomotors in biosensing and biomedical applications is the ability to

Synapsable quadruplex-mediated fibers

May 3, 2013
Author(s)
Veronika A. Szalai, Miguel A. Mendez
We have fabricated and characterized a novel DNA based nanofiber created by synergistic self-assembly of guanine quadruplex (Hoogsteen base pairing) and double-stranded DNA (Watson-Crick base pairing). The assembly of our nanofibers occurs in several steps

Temperature sculpting in yoctoliter volumes

February 14, 2013
Author(s)
Joseph E. Reiner, Joseph W. Robertson, Daniel L. Burden, Lisa K. Burden, Arvind Balijepalli, John J. Kasianowicz
The ability to perturb large ensembles of molecules from equilibrium led to major advances in understanding reaction mechanisms in chemistry and biology. Here, we demonstrate the ability to control, measure, and make use of rapid temperature changes of
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