NOTICE: Due to a lapse in annual appropriations, most of this website is not being updated. Learn more.
Form submissions will still be accepted but will not receive responses at this time. Sections of this site for programs using non-appropriated funds (such as NVLAP) or those that are excepted from the shutdown (such as CHIPS and NVD) will continue to be updated.
An official website of the United States government
Here’s how you know
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Surface-Engineered Nanomaterials as X-ray Absorbing Adjuvant Agents for Auger-Mediated Chemo-Radiation
Published
Author(s)
Robert F. Cook, Sang-Min Lee, De-Hao D. Tsai, Vincent A. Hackley, Martin W. Brechbiel
Abstract
We demonstrate a prototype approach to formulate gold nanoparticle (AuNP)based Xray absorbing adjuvant agents through surfaceengineering of cisplatin pharmacophore (PtII) with lipoic acidmodified polyacrylate (denoted as PtIIAuNPs). Design of PtIIAuNPs was examined and further validated using a combination of physicochemical characterization methods. Our results show PtIIAuNPs exhibits very high capacity for PtII loading via the mechanism of multidentate coordination between PtII ions and surfacebound polyacrylate. The PtIIAuNP vector presented excellent colloidal stability in an acidsensitive manner that enables PtII drugrelease, and exhibited high in vitro cytotoxicity to the cancer cell lines MCF7 and SKOV3. Secondary electron emissions from both PtII and AuNPs are triggered by an external ionizing radiation source via the Auger cascade. As a result, PtIIAuNPs exhibit therapeutic potential as an adjuvant agent for concurrent chemoradiation cancer therapy.
Cook, R.
, Lee, S.
, Tsai, D.
, Hackley, V.
and W., M.
(2013),
Surface-Engineered Nanomaterials as X-ray Absorbing Adjuvant Agents for Auger-Mediated Chemo-Radiation, Nanoscale, [online], https://doi.org/10.1039/c3nr00333g
(Accessed October 11, 2025)