Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport

Published

March 21, 2014

Author(s)

Wyatt N. Vreeland, Renee R. Hood, Eric Kendall, Don L. DeVoe, Julia Finkel, Mariana Junqueira, Zenaide Quezado

Abstract

Microfluidic synthesis of small and nearly-monodisperse liposomes is used to investigate the size-dependent passive transdermal transport of nanoscale lipid vesicles. While large liposomes with diameters above 105 nm are found to be excluded from deeper skin layers past the stratum corneum, the primary barrier to nanoparticle transport, liposomes with mean diameters between 31 nm to 41 nm exhibit significantly enhanced penetration. Furthermore, multicolor fluorescence imaging reveals that the smaller liposomes pass rapidly through the stratum corneum without vesicle rupture. These findings reveal that nanoscale liposomes with well controlled size and minimal size variance are excellent vehicles for transdermal delivery of functional nanoparticle drugs.

Citation

PLoS One

Volume

9

Issue

3

Pub Type

Journals

Download Paper

DOI Link

Keywords

drug delivery, nano medicine, nanoparticles

Citation

Vreeland, W. , Hood, R. , Kendall, E. , DeVoe, D. , Finkel, J. , Junqueira, M. and Quezado, Z. (2014), Microfluidic-Enabled of Liposomes Elucidate Size-Dependent Transdermal Transport, PLoS One, [online], https://doi.org/10.1371/journal.pone.0092978 (Accessed October 9, 2025)