U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PUBLICATIONS

Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing

Published

Author(s)

Eugene Paulechka, Tsjerk A. Wassenaar, Kenneth Kroenlein, Andrei F. Kazakov, Alex Smolyanitsky

Abstract

We propose a water-immersed nucleobase-functionalized suspended graphene nanoribbon as an intrinsically selective device for nucleotide detection. The proposed sensing method combines Watson–Crick selective base pairing with graphene's capacity for converting anisotropic lattice strain to changes in an electrical current at the nanoscale. Using detailed atomistic molecular dynamics (MD) simulations, we study sensor operation at ambient conditions. We combine simulated data with theoretical arguments to estimate the levels of measurable electrical signal variation in response to strains and determine that the proposed sensing mechanism shows significant promise for realistic DNA sensing devices without the need for advanced data processing, or highly restrictive operational conditions.
Citation
Nanoscale
Pub Type
Journals

Download Paper

DOI Link

Keywords

bionanotechnology, nanotechnology, DNA sequencing, graphene, graphene nanoribbon, gnr
Nanophysics, Nanochemistry and Nanobiotechnology

Citation

Paulechka, E. , Wassenaar, T. , Kroenlein, K. , Kazakov, A. and Smolyanitsky, A. (2015), Nucleobase-functionalized graphene nanoribbons for accurate high-speed DNA sequencing, Nanoscale, [online], https://doi.org/10.1039/C5NR07061A (Accessed April 25, 2024)

Created December 23, 2015, Updated September 28, 2022