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Molecular and BioPhotonics Group

Photonic techniques, which use light to image, detect, and manipulate molecules and biomolecules, are used to establish the optical measurement science, modeling, and simulation tools to enable the characterization and control of molecular systems.

Molecular and BioPhotonics research lies at the intersection of physics, chemistry, engineering, and life sciences. The ability to measure and quantify molecular systems is critical to realizing many applications in medicine, energy, and the environment.

The group's research effort focuses on the development of the following:

  • Development of new optical methods using spectroscopy and microscopy for enhanced detection of molecules and biomolecules;
  • Advancing the understanding of the interaction between biological systems and photons;
  • Diagnostic and clinical standards for validating the efficacy of biophotonics-based applications and understanding the fundamental physics underlying new biophotonics-based therapeutic techniques; and
  • Measurement standards for improving manufacturing quality and promoting acceptance of biophotonics technology

News and Updates

Seeing Into Cells More Clearly

NIST scientists, with collaborators at the University of Michigan, have designed and demonstrated a new and easily tunable, high-contrast scattering agent for

Projects and Programs

Nano-biophotonics for molecular imaging

Biophotonics is at the intersection of photonics and biology where light is used to image, detect, and manipulate biological materials. This project addresses



JB95 Spectral fitting program

A graphical user interface program, JB95, based on a Windows 95© API platform has been written in the C programming language to aid in the analysis of complex

Tools and Instruments

Continuous-wave terahertz spectrometer

The continuous-wave terahertz spectrometer makes use of two near-infrared lasers. The first laser is a fixed-frequency cw ring Ti:Saph laser operating near 840

Nonlinear Optical Spectroscopy

Vibrationally-Resonant Sum Frequency Spectroscopy (VR-SFS): A nonlinear vibrational spectroscopy in which two colors of light, one in the visible and one in the



Group Leader

Postal address: Molecular and Biophotonics Group, NIST - 687.05, 325 Broadway, Boulder, CO 80305