Projects/Programs

Displaying 1 - 24 of 24

RM 8376 Microbial Pathogen DNA Standards for Detection and Identification

Ongoing

Metagenomic Next Generation Sequencing (mNGS) promises to revolutionize infectious disease diagnostics. However, the analytical performance of this technology

DARPA Friend or Foe (FoF) -- Independent Verification and Validation (IV&V)

Ongoing

The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different

Engineering of G Protein-Coupled Receptors

Ongoing

We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune

Human Gut Microbiome Reference Material

Ongoing

To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need

Large-Scale Genotype-Phenotype Landscape Measurements for Precision Engineering of Living Measurement Systems

Ongoing

All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the

Living Yeast Cell Reference Material (RM 8230)

Ongoing

Confidence in total or viable microbial cell counting methods is lacking, due in part to a dearth of relevant reference materials. NIST has developed a living

S Mutans SEM image, in the process of forming complex networks.

Measurements for Microbial Ecology

Ongoing

Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such

Measuring Antimicrobial Resistance

Ongoing

NIST is developing microbial measurements to better understand the propagation of antimicrobial resistance (AMR) through a variety of mechanisms. This work

Absolute quantitation of mRNA molecules in bacterial cells

Methods for Absolute Quantitation of Transcription

Ongoing

Measurements of the performance of engineered organisms are typically not reproducible or comparable across different laboratories. So, to enable meaningful

Methods to Quantify Microbial Viability

Ongoing

Accurate measurement of microbial viability is crucial in infectious disease diagnosis and treatment; for development of microbial therapeutics, probiotics and

Microbial Cell Quantification Methods – Toward Whole Cell Reference Materials

Ongoing

Reference materials (RMs) consisting of whole microbial cells characterized for total cell number and total DNA are needed to evaluate and compare cell counting

Microbial Genomic Measurements

Completed

Increasingly, high stakes decisions impacting public health and safety are being made using microbial genomic sequencing data. For example, whole genome

Figure showing four components of metabolomics with samples and processing

Microbial Metabolomics

Ongoing

There is a growing need to establish quality assurance and measurement strategies to address microbial function and emergent activities related to interspecies

Mpox (MPXV) Synthetic DNA PCR Standards

Ongoing

Update: CDC NWSS has recently shared two published CDC diagnostic assays, non-variola orthopoxvirus (NVO) and MPXV Clade II virus. Targets for these 2 assays

Nanocalorimetry Measurements

Ongoing

Nanocalorimetry provides a capability to measure the thermal properties of very small samples and at very fast rates. Materials and interfaces of interest

NIST Living Measurement Systems Foundry

Ongoing

The goal of the NIST Living Measurement Systems Foundry is to enable the engineering of cells for reliable and safe use in dynamic and unpredictable

NIST Microbial Strain Collection

Ongoing

NIST established the NIST Microbial Strain Collection (NMSC) to advance microbial research and support standards development. The NMSC will accept deposits of

NIST Rapid Microbial Testing Methods Consortium

Ongoing

The NIST Rapid Microbial Testing Methods (RMTM) Consortium addresses the need for measurements and standards, including reference materials, to increase

Pathogen Detection and Identification in the Clinical Setting: The Next Generation of Analyses

Ongoing

NIST and FDA are co-developing DNA-based materials for mixed microbial detection. Our annual workshop brings together private and public interests to discuss

RMAT Laboratory Programs

Ongoing

The NIST Regenerative Medicine and Advanced Therapies (RMAT) laboratory programs are focused on developing innovative measurement assurance solutions and

DNA Plasmid containing 13 PCR targets for water quality testing

Standards for Assessing the Safety of Recreational Waters from Fecal Contamination

Completed

Contamination of waterways with fecal material leads to the dissemination of pathogens and antibiotic-resistant bacteria that can have serious impacts on human

Standards for Metagenomics

Ongoing

Metagenomics, or identifying the organisms present in a sample through DNA-based analysis, is a revolutionary technology made possible through advances in

First responders collecting samples of the yeast surrogate material during a field exercise. (Credit: NIST)

Standards to Support Biothreat Detection

Ongoing

First responders continually receive calls regarding suspicious materials that are potentially biological threat materials. Obtaining high confidence data from

Surrogate Materials to Support Training in Biological Sampling and Detection in the Field

Ongoing

Developing and maintaining a nationwide capability in field biological assessment requires routine training with biological materials. Attenuated biothreat

NIST Headquarters
-Creating Helpful Incentives to Produce Semiconductors for America (CHIPS)
--CHIPS Program Office
---CHIPS Program Headquarters
----CHIPS Program Headquarters - HQ
----Opportunity & Inclusion Group
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----External & Government Affairs – HQ
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---Semiconductor Manufacturing Institute Division
----Semiconductor Manufacturing Institute – HQ
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----Radiation Safety - HQ
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----Boulder Safety, Health and Environment - HQ
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---Financial Systems and Reporting Division
----CBS Core Support Group
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----Financial Systems and Reporting Division - HQ
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---Office of Financial Resource Management
----Office of Financial Resource Management - HQ
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---Finance Division
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----Financial Statements Group
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----Budget - HQ
----Formulation and Financial Management Group
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--Communications Technology Laboratory
---RF Technology Division
----High-Speed Waveform Metrology Group
----Superconductive Electronics Group
----Metrology for Wireless Systems Group
----Guided Wave Electromagnetics Group
----Electromagnetic Fields Group
----RF Technology Division - HQ
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----IoT Devices and Infrastructures Group
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----Smart Connected Manufacturing Systems Group
----Smart Grid Group
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---Spectrum Technology and Research Division
----Applied Systems Metrology Group
----Fiber Sources and Applications Group
----Shared Spectrum Metrology Group
----Spectrum Technology and Research – HQ
---Wireless Networks Division
----Internet Technologies Research Group
----Radio Access and Propagation Metrology Group
----Wireless Networks Division - HQ
----Wireless Systems Innovation and Performance Group
---Public Safety Communications Research Division
----Public Safety Communications Research Division - HQ
----Advanced Communications Research Group
----Network Operations Group
---Communications Technology Laboratory HQ
----Communications Technology Laboratory HQ Gp
----Boulder Laboratory Director Office
----Communication Test Coordination Office
--Engineering Laboratory
---Building Energy and Environment Division
----Building Energy and Environment - HQ
----Mechanical Systems and Controls Group
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----Heat Transfer and Alternative Energy Systems Group
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----Intelligent Systems - HQ
----Manipulation and Mobility Systems Group
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---Materials and Structural Systems Division
----Earthquake Engineering Group
----Infrastructure Materials Group
----Inorganic Materials Group
----Community Resilience Group
----Materials and Structural Systems - HQ
----Polymeric Materials Group
----Structures Group
---Engineering Laboratory Office
----Applied Economics Office
----Engineering Laboratory - HQ
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---Fire Research Division
----National Fire Research Laboratory Group
----Wildland Urban Interface Fire Group
----Flammability Reduction Group
----Fire Research - HQ
----Engineered Fire Safety Group
----Fire Fighting Technology Group
---Systems Integration Division
----Life Cycle Engineering Group
----Process Engineering Group
----Information Modeling and Testing Group
----Systems Integration - HQ
--Information Technology Laboratory
---Applied Cybersecurity Division
----Applied Cybersecurity - HQ
----Cybersecurity and Privacy Applications Group
----National Cybersecurity Center of Excellence
----Trusted Identity Initiative Group
----NICE
---Computer Security Division
----Computer Security - HQ
----Cryptographic Technology Group
----Secure Systems and Applications Group
----Security Components and Mechanisms Group
----Security Test, Validation and Measurement Group
----Security Engineering and Risk Management Group
---Applied and Computational Mathematics Division
----Mathematical Software Group
----Mathematical Analysis and Modeling Group
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----High Performance Computing and Visualization Group
----Applied and Computational Mathematics - HQ
---Statistical Engineering Division
----Applied and Computational Statistics Group
----Statistical Design, Analysis, and Modeling Group
----Statistical Engineering - HQ
---Software and Systems Division
----Systems Interoperability Group
----Software Quality Group
----Software and Systems - HQ
----Cyber Infrastructure Group
----Information Systems Group
---Information Access Division
----Information Access - HQ
----Image Group
----Multimodal Information Group
----Retrieval Group
----Visualization and Usability Group
---Information Technology Laboratory Office
----Office of Computational Science for Metrology
----Office of Emerging Technologies
----Office of IT Standardization
----Office of Government and Industrial Liaison
----Information Technology Laboratory Office - HQ
----Office of Chief Cybersecurity Advisor
--Laboratory Programs
---Research Protections Office
----Research Protections Office - HQ
---Standards Coordination Office
----International Standards Policy and Coordination Group
----Standards and Conformity Assessment Services Group
----Standards Coordination Office - HQ
----National Voluntary Laboratory Accreditation Program (NVLAP)
---Special Programs Office
----Special Programs Office-HQ
----Law Enforcement Standards Office
---Associate Director for Laboratory Programs
----Associate Director for Laboratory Programs - HQ
--Material Measurement Laboratory
---Office of Reference Materials
----Business and Quality Management Group
----Business Application Development, Support, and Security Group
----Sales and Customer Services Group
----Publication and Web Services Group
----Office of Reference Materials - HQ
----Materials and Physical Services Group
---Office of Data and Informatics
----Office of Data and Informatics - HQ
----Data Services Group
----Data Sciences Group
---Biosystems and Biomaterials Division
----Biomarker and Genomic Sciences Group
----Cellular Engineering Group
----Biomaterials Group
----Genome-Scale Measurements Group
----Complex Microbial Systems Group
----Cell Systems Science Group
----Biosystems and Biomaterials Division - HQ
---Chemical Sciences Division
----Biochemical and Exposure Science Group
----Chemical Informatics Group
----Optical Measurements Group
----Chemical Process and Nuclear Measurements Group
----Gas Sensing Metrology Group
----Inorganic Chemical Metrology Group
----Biospecimen Science Group
----Environmental Chemical Sciences Group
----Chemical Sciences Division - HQ
----Marine Biochemical Sciences Group
----Organic Chemical Metrology Group
---Biomolecular Measurement Division
----Biomolecular Structure and Function Group
----Mass Spectrometry Data Center Group
----Bioprocess Measurements Group
----Bioanalytical Science Group
----Biomolecular Measurement Division - HQ
----Applied Genetics Group
---Applied Chemicals and Materials Division
----Applied Chemicals and Materials Division - HQ
----Thermodynamics Research Center Group
----Thermophysical Properties of Fluids Group
----Nanoscale Reliability Group
----Fluid Characterization Group
----Fatigue and Fracture Group
---Materials Science and Engineering Division
----Thermodynamics and Kinetics Group
----Polymers Processing Group
----Mechanical Performance Group
----Polymers and Complex Fluids Group
----Materials Science and Engineering Division - HQ
----Functional Polymers Group
----Functional Nanostructured Materials Group
---Materials Measurement Science Division
----Security Technologies Group
----Surface and Trace Chemical Analysis Group
----Nanomechanical Properties Group
----Nano Materials Research Group
----Materials Structure and Data Group
----Microscopy and Microanalysis Research Group
----Synchrotron Science Group
----Materials Measurement Science Division - HQ
----Data and AI-Driven Materials Science Group
---Material Measurement Laboratory Office
----The Material Measurement Laboratory Office of Operations Group
----Material Measurement Laboratory - HQ
----Genome-Scale Measurement Group
--NIST Center for Neutron Research
---NIST Center for Neutron Research
----Research Facility Operations Group
----NIST Center for Neutron Research - HQ
----Reactor Operations and Engineering Group
----Neutron-Condensed Matter Science Group
--Physical Measurement Laboratory
---Microsystems and Nanotechnology Division
----Biophysical and Biomedical Measurement Group
----Microsystems and Nanotechnology - HQ
----Nanostructure Fabrication and Measurement Group
----Photonics and Optomechanics Group
---Time and Frequency Division
----Atomic Devices & Instrumentation Group
----Precision Photonic Synthesis Group
----Quantum & Nonlinear Nanophotonics Group
----Atomic Standards Group
----Ion Storage Group
----Neutral Atom Optical Clocks Group
----Time Realization and Distribution Group
----Phase Noise Metrology Group
----Time and Frequency - HQ
---Quantum Physics Division
----Quantum Physics - HQ
---Radiation Physics Division
----Dosimetry Group
----Radioactivity Group
----Radiation Physics - HQ
----Neutron Physics Group
---Sensor Science Division
----Fundamental Thermodynamics Group
----Ultraviolet Radiation Group
----Sensor Science - HQ
----Dimensional Metrology Group
----Temperature & Humidity Group
----Remote Sensing Group
----Optical Radiation Group
----Fluid Metrology Group
----Surface and Interface Metrology Group
---Applied Physics Division
----Advanced Microwave Photonics Group
----Spin Electronics Group
----Applied Physics - HQ
----Faint Photonics Group
----Quantitative Nanostructure Characterization Group
----Quantum Devices Group
----Molecular and Bio-Photonics Group
----Optoelectronic Manufacturing Group
----Magnetic Imaging Group
----Quantum Nanophotonics Group
----Sources and Detectors Group
---Quantum Measurement Division
----Quantum Optics Group
----Mass and Force Group
----Quantum Measurement - HQ
----Laser Cooling and Trapping Group
----Fundamental Electrical Measurements Group
----Applied Electrical Metrology Group
----Atomic Spectroscopy Group
---Quantum Sensors Division
----Device Fabrication Group
----Long Wavelength Sensors and Applications Group
----Quantum Calorimeters Group
----Quantum Electronics Group
----Quantum Processing Group
----Quantum Sensors Group
----Quantum Sensors – HQ
----Nanoscale Spin Dynamics Group
----Microfabrication Group
----Spin Electronics Group
----Magnetics Group
---Nanoscale Device Characterization Division
----Atom Scale Device Group
----Nanoscale Device Characterization Division - HQ
----Alternative Computing Group
----Nanoscale Spectroscopy Group
----Advanced Electronics Group
----Nanoscale Processes and Measurements Group
---Physical Measurement Laboratory Office
----Boulder Microfabrication Facility
----Physical Measurement Laboratory- HQ
----PML Information Office
----Center for Nanoscale Science and Technology
----Office of Weights and Measures
----Boulder Laboratory Director Office
-Innovation & Industry Services
--Office of Advanced Manufacturing
---Microelectronics Manufacturing Division
----Microelectronics Manufacturing – HQ
----Microelectronics Strategy and Enterprise Group
----Semiconductor Coordination Group
----Semiconductor Operations Group
----Workforce and Equity Development Group
---Office of Advanced Manufacturing
----Office of Advanced Manufacturing - HQ
---Partnerships and Outreach Division
----Communications and Marketing Group
----Education and Workforce Development Group
----Partnership Engagement Group
----Partnerships and Outreach – HQ
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---Policy and Strategy Division
----Analysis and Benchmarking Group
----Policy and Strategy – HQ
----Strategic Planning Group
---Program Operations Division
----Competitions Group
----Institute and Program Management Group
----Performance Management Group
----Program Operations - HQ
--Baldrige Performance Excellence Program
---Baldrige Performance Excellence Program Office
----Award Process Group
----Director's Office, Baldrige Performance Excellence Program
----Administrative Support/Electronic Information Group
----Outreach and Communications Group
----Publications Management Group
----Workforce Development Group
--Innovation & Industry Services
---Associate Director for Innovation & Industry Services
----Associate Director for Innovation & Industry Services - HQ
---Advanced Manufacturing Office
----Advanced Manufacturing Office - HQ
---Economic Analysis Office
----Economic Analysis Office - HQ
---Technology Partnerships Office
----Technology Partnerships Office - HQ
---Technology Innovation Program Office
----Technology Innovation Program Office - HQ
--Hollings Manufacturing Extension Partnership Program
---National Platforms Division
----National Platforms – HQ
----Network Knowledge Management Group
----Supply Chain Group
---National Programs Division
----National Programs- HQ
---Network Learning and Strategic Competitions Division
----Network Learning and Strategic Competitions - HQ
---Outreach and External Affairs Division
----Outreach and External Affairs – HQ
---Performance Evaluation and Economic Impacts Division
----Performance Evaluation and Economic Impacts - HQ
----Performance Metrics and Evaluation Group
---Regional and State Partnerships Division
----Regional Management Group
----Regional and State Partnerships - HQ
---Network Agreements Management Division
----Network Agreements Management - HQ
----Node B Group
----Node A Group
---Internal Operations Division
----Internal Operations – HQ
----Center Operations and Financial Management Group
---Extension Services Division
----Extension Services - HQ
---Hollings Manufacturing Extension Partnership Program Office
----Hollings Manufacturing Extension Partnership Program - HQ
-Director's Office
--Director's Office
---Diversity, Equity and Inclusivity Office
----Diversity, Equity and Inclusivity Office - HQ
---Ombuds Office
----Ombuds Office - HQ
---Public Affairs Office
----Media Liaison Group
----Video and Digital Media Production Group
----Public Affairs Office - HQ
----Internal Communications and Inquiries Group
----Conference Program and Audiovisual Services Group
----Boulder Meetings Support and Services Group
----Web Content Development Group
---Program Coordination Office
----Program Coordination Office - HQ
---Director's Office
----Director's Office - HQ
----Onboarding Group
---Congressional and Legislative Affairs Office
----Congressional and Legislative Affairs Office - HQ
---Human Subjects Protection Office
----Human Subjects Protection Office - HQ
---Management and Organization Office
----Management and Organization Office- HQ
---International and Academic Affairs Office
----International and Academic Affairs Office - HQ