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Metagenomic Next Generation Sequencing (mNGS) promises to revolutionize infectious disease diagnostics. However, the analytical performance of this technology
The development of new platforms for characterization of complex microbial samples are hampered by lack of reproducibility and comparability across different
We work to engineer novel function in GPCRs using a microbial platform. This enables rapid, and multi-objective engineering, to precisely characterize and tune
To identify new biomarkers that may serve as disease indicators and to understand biologically relevant properties of the human gut microbiome, we need
All living things measure their environment, make decisions, and respond. Systematic re-engineering of these living measurement and control systems has the
Confidence in total or viable microbial cell counting methods is lacking, due in part to a dearth of relevant reference materials. NIST has developed a living
Because of the complexity of microbial communities, we are working to develop measurements that will enable more reproducible design and control over of such
Measurements of the performance of engineered organisms are typically not reproducible or comparable across different laboratories. So, to enable meaningful
Accurate measurement of microbial viability is crucial in infectious disease diagnosis and treatment; for development of microbial therapeutics, probiotics and
Reference materials (RMs) consisting of whole microbial cells characterized for total cell number and total DNA are needed to evaluate and compare cell counting
Increasingly, high stakes decisions impacting public health and safety are being made using microbial genomic sequencing data. For example, whole genome
There is a growing need to establish quality assurance and measurement strategies to address microbial function and emergent activities related to interspecies
Nanocalorimetry provides a capability to measure the thermal properties of very small samples and at very fast rates. Materials and interfaces of interest
NIST established the NIST Microbial Strain Collection (NMSC) to advance microbial research and support standards development. The NMSC will accept deposits of
The NIST Rapid Microbial Testing Methods (RMTM) Consortium addresses the need for measurements and standards, including reference materials, to increase
NIST and FDA are co-developing DNA-based materials for mixed microbial detection. Our annual workshop brings together private and public interests to discuss
The NIST Regenerative Medicine and Advanced Therapies (RMAT) laboratory programs are focused on developing innovative measurement assurance solutions and
Contamination of waterways with fecal material leads to the dissemination of pathogens and antibiotic-resistant bacteria that can have serious impacts on human
Metagenomics, or identifying the organisms present in a sample through DNA-based analysis, is a revolutionary technology made possible through advances in
First responders continually receive calls regarding suspicious materials that are potentially biological threat materials. Obtaining high confidence data from
Developing and maintaining a nationwide capability in field biological assessment requires routine training with biological materials. Attenuated biothreat