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Material Measurement Laboratory

Projects/Programs

Displaying 526 - 550 of 575

Synthetic Biology

Ongoing
New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the

U.S. TAG for ISO/TC276: Biotechnology

Ongoing
Get involved: Interested U.S. Stakeholders may participate in the US TAG at no cost. Membership provides access to all ISO/TC 276 and US TAG documents, including standards under development. Please click here to join. Contribute to standards development: Please click here to review, submit comment

Tandem Mass Spectral Library

Ongoing
Intended Impact Modern mass spectrometers commonly generate ions by electrospray mass spectrometry which are separated and then fragmented by collisional dissociation. This process yields fragment ion ‘fingerprints’ (or mass spectra) that are widely used to identify the individual components in a

Targeting Membrane Proteins

Ongoing
Membrane proteins constitute approximately 30% of all cellular proteins. Nevertheless, this group of proteins is traditionally understudied due to limitations of the available analytical tools. Given the importance of membrane proteins in the various cellular processes and their potential as drug

Teaching Liquid State Theory to an Artificial Neural Network (ANN)

Ongoing
Scientific questions: Can an ANN allow us to predict the structure of fluids that are impossible to predict numerically via liquid-state theory? Can we learn something about liquid-state theory itself by the nature of the trained ANN? What features do the hidden layers capture?
Fish on a ruler to measure length, about 47 cm from head to tail.

Technological Advances in Aquaculture

Ongoing
According to the NOAA Fisheries of the U.S. report, in 2020 U.S. seafood consumption was estimated at ~6B pounds (~2.7 x 109 kg). Of that, 85% is imported and U.S. exports have seen a significant decline. Globally, the U.S. ranked only 18th in aquaculture production (2020). NIST aims to enhance the

Templated Assembly of Block Copolymer Films

Completed
Viable nanomanufacturing of templated block copolymers will require a capability to control orientation and line edge roughness of trillions of structures to within a single nanometer, however there are no existing platforms that meet this need. We are developing small angle x-ray and neutron

Tension-Compression Testing

Ongoing
The inability to reliably predict the mechanical behavior of new automotive alloys during forming has generated strong demand for more advanced constitutive relationships and property data necessary to calibrate them. There is a particular need for models that incorporate combined kinematic and
Schematic figure illustrating the principle of operation of a mass spectrometer, showing deflection of ions based on mass.

Theoretical Mass Spectrometry

Ongoing
No Description Intended Impact Unknown compounds will be identified more reliably. Quality control for the NIST Mass Spectrometry Database will be enhanced. Goals Develop software tools for predicting microcanonical branching fractions automatically. This is currently too laborious and too technical

Thermal Desorption Ambient Mass Spectrometry

Ongoing
The Surface and Trace Chemical Analysis Group is involved in a number of research avenues for the rapid screening of wipe-collected samples for the security and forensic chemistry fields. Similar to the widely-deploy ion mobility spectrometry (IMS) systems for screening, this is accomplished through

Thermodynamic & Kinetic Data for Sustainable Energy

Completed
Knowledge of the thermodynamic, phase equilibria and diffusion properties of potential novel materials can greatly accelerate their development. However, the data needed for new, multi-component materials are often not available. The CALPHAD (Computer Coupling of Phase Diagrams and thermochemistry)
reaction coordinate

Thermodynamics of Enzyme-catalyzed Reactions

Ongoing
Current efforts are focused on industrially important biotransformation problems such as those found in hydrogenation, hydroxylation, aromatic amino acid metabolic pathways, and biofuel applications. The methods used include calorimetry, chromatography, enzymology, and spectrophotometry. The

Time-of-Flight Secondary Ion Mass Spectrometry

Ongoing
ToF-SIMS is an imaging mass spectrometry (MS) technique that allows us to obtain isotopic, elemental, and molecular information from the surface of solid samples. A pulsed, energetic “primary” ion beam bombards the surface and induces a collision cascade, liberating “secondary” ions that are then

Tissue Engineering

Ongoing
Tissue Engineering Measurands: Tissue engineering measurands are confusing to discuss and a charting method to improve communication is demonstrated. Measurement Assurance Strategies for Regenerative Medicine: Reliable methods for assessing product consistency and quality. Regenerative Medicine

Tissue Engineering Measurands

Ongoing
Making a Measurand Chart: A measurand chart can be created for any measurement by writing down all the measurands that occur during the measurement. The panels should not be procedural steps, such as “wash the sample with buffer” or “centrifuge the microfuge tubes”. Consider if the measurement has a
Photo of blood droplets

Toxicology

Ongoing
Development of Low-Volume Drop Blood Drug Screening Tools This project aims to leverage recent NIST advances in ambient ionization mass spectrometry to develop platforms for low-volume blood drug screening. Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Paper Spray Ionization Mass

Trace Contraband Detection

Ongoing
Screening of people and their belongings including luggage, vehicles, and packages for the presence of trace residues of explosives and narcotics (trace contraband detection) is widely used in aviation security and law enforcement. In common screening scenarios, trace contraband residues in the form

Traceability in Molecular Spectrophotometry

Ongoing
This program, sometimes referred to as the Optical Filters program, has supported the development, certification, and (as specified) recertification of Standard Reference Materials ® (SRMs ®) for the verification of the transmittance (absorbance) and wavelength scales of spectrophotometers in the
Photography of gas cylinder storage facility with cylinders stored horizontally in movable cabinets.

Traceable Calibration Gases: SRMs, NTRMs, and Protocol Gases

Ongoing
The Gas Sensing Metrology Group prepares the highest level gas standards, known as Primary Standard Gas Mixtures based on precise gravimetric methods and accurate purity analysis. These Primary Standards are verified at NIST, stability confirmed through reanalysis over many years, and compared

Training for Screeners and Lab Staff

Ongoing
Advances in primary screening technologies (x-ray, CT, AIT) have allowed the detection and discrimination of bulk quantities of potentially dangerous compounds on people or in bags. However, a secondary screening method - typically based on trace detection - is still required for correct

Transport Properties of Complex Particles and Polymers

Ongoing
Our approach is divided into several technical approaches: 1) Precise particle shape specification based on observation, 2) calculation of particle properties and 3) the calculation of the effect of particle shape on the properties of the polymer materials. Our computational webtool ZENO
SRM 3452 certified Seebeck coefficient data

Transport Property Measurements for Semiconductors and Energy Materials

Ongoing
The properties of materials and interfaces that govern reliability, performance, and thermal transport in advanced microelectronic packages are not fully characterized or understood, especially at device length scales wherein properties may differ significantly from bulk or literature values
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