Our goal is to develop reliable tools and standards for measuring the properties of cells, biomaterials, scaffolds and tissue-engineered constructs. As regenerative medicine moves from a research endeavor to a viable industry that benefits patients and U.S. commerce, reliable methods for assessing product consistency and quality are required.
Measurement Assurance Strategies for Regenerative Medicine: Reliable methods for assessing product consistency and quality.
Regenerative Medicine: Clinical translation of advanced therapies requires better characterization of products and more robust, reliable, and cost-effective manufacturing processes.
ASTM Committee F04 on Tissue-Engineered Medical Products: ASTM serves a neutral ground where stakeholders can openly discuss and develop standards for measurements of product attributes.
Absorbance Imaging & AI for Assessing Quality of Tissue Engineered Retinal Pigment Epithelium: Measurement of RPE pigmentation as a non-invasive method to assess tissue quality during biomanufacturing.
Combinatorial Cassettes: Combi-cassettes enable 19 tissue-engineered constructs to be placed into one mouse, improving the quantitative rigor of animal tests.
Measuring Cell Viability in Scaffolds: An ASTM working group has been formed to develop a standard test method for assessing viability of cells encapsulated in hydrogel scaffolds.
Scaffold Characterization: Validated, open-source ImageJ plugin (DiameterJ) for automated measurement of nanofiber diameter in scanning electron micrographs.
3D Cell-Scaffold Interactions: 3D imaging of cells and scaffolds to provide fundamental principles for design of 3D tissue-engineered constructs.
Scaffold Fabrication: Airbrushed Scaffods & Combinatorial Methods: Methods for fabricating scaffolds and scaffold libraries.
Scaffold Handling Device: A positive and negative air pressure device for efficient and gentle handling of nanofiber scaffolds.
Reference Material Scaffolds: Reference material scaffolds to enhance comparability of scaffold measurements made in different labs.
Regenerative medicine represents a new paradigm in human health with the potential to resolve unmet clinical needs through technologies that are specifically developed to modify diseases and enable tissue regeneration or replacement.
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