The Engineering Biology Team pursues metrology for microbial systems to define and tune biological context and harness quantitative evolution for prediction, control, and design. Context dependence and evolution stand as unique challenges for synthetic biology, distinct from more traditional engineering disciplines. Effective measurements are needed to foster innovation and practical applications of engineered biological systems, by increasing reproducibility and collaboration. In this way, we aim to advance our fundamental understanding, improve predictability for design, ensure comparability of data between research laboratories, and enable scalability for practical applications of synthetic biology. The Engineering Biology Team takes a dynamic, multidisciplinary approach, partnering actively with other institutions and agencies in collaborative efforts.
Current Technical Scope
- Improve measurement comparability and predictability for transcription-based control of bacteria
- Design and optimization of living measurement systems using directed evolution
- Enable comparability and reproducibility using quantitative flow cytometry for engineered microbial systems
- Deliver methods to determine the evolutionary stability of engineered function
- Quantify performance of cell-free systems for rapid design-build-test of genetic parts
Postdoctoral Research Opportunities