Elizabeth Strychalski

Complex Microbial Systems Group
elizabeth.strychalski@nist.gov
(301) 975-5951

Education

PhD - Physics, Cornell University

BS - Physics and Astronomy, University of Rochester

BA - Religion, University of Rochester

Dr. Strychalski focuses on applying synthetic biology as a tool to discover and test the fundamental rules underpinning complex biological systems broadly across multiple length and time scales. This understanding informs quantitative measurements, theoretical modeling, and the rational design of biological systems. The multidisciplinary nature of the topic necessitates a highly collaborative approach, leveraging experimental, theoretical, and numerical techniques across the sciences and engineering.

 

Postdoctoral Research Opportunities

 

National Research Council Research Associateship Program at NIST:

Selected Publications

 

  • DNA Purification From Crude Samples for Human Identification Using Gradient Elution Isotachophoresis
    E.A. Strychalski, C. Konek, E. R. Butts, P. M. Valone, A. C. Henry, D. Ross
    Electrophoresis, Vol. 34, No. 17, pp. 2522-2530, 2013
  • A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement
    E. A. Strychalski*, S. M. Stavis*, J. Geist*
    * These authors contributed equally
    AIP Advances, Vol. 3, No. 4, 042115, 2013
  • Quantitative Size Measurements of Linear and Circular DNA in Nanofluidic Slitlike Confinement
    E. A. Strychalski*, J. Geist, M. Gaitan, L. E. Locascio, S. M. Stavis*
    * These authors contributed equally
    Macromolecules, Vol. 45, No. 3, pp. 16021611, 2012
  • DNA Molecules Descending a Nanofluidic Staircase by Entropophoresis
    S. M. Stavis*, J. Geist, M. Gaitan, L. E. Locascio, E. A. Strychalski*
    * These authors contributed equally
    Lab on a Chip, Vol.12, No. 6, pp. 11741182, 2012
    Virtual Journal of Biological Physics Research
  • Expanding the Capabilities of Microfluidic Gradient Elution Moving Boundary Electrophoresis for Complex Samples
    E. A. Strychalski, A. C. Henry, D. Ross
    Analytical Chemistry, Vol. 83, No. 16, pp. 63166322, 2011
  • Microfluidic Analysis of Complex Samples With Minimal Sample Preparation Using Gradient Elution Moving Boundary Electrophoresis
    E. A. Strychalski, A. C. Henry, D. Ross
    Analytical Chemistry, Vol. 81, No. 24, pp. 1020110207, 2009 Cover Article
  • Non-equilibrium Length-based Separation of Short DNA using Nanoslit Arrays
    E. A. Strychalski, H. W. Lau, L. A. Archer
    Journal of Applied Physics, Vol. 106, No. 2, 024915, 2009 Virtual Journal of Biological Physics Research
  •  Nanofluidic Structures with Complex Three Dimensional Surface Topographies
    S. M. Stavis, E. A. Strychalski, M. Gaitan
    Nanotechnology, Vol. 20, No. 16, 165302, 2009
    Featured in Nanotechnology 2009 Highlights collection
  • Diffusion of DNA in Nanoslits
    E. A. Strychalski*, S. Levy*, and H. G. Craighead
    * These authors contributed equally
    Macromolecules, Vol. 41, No. 20, pp. 7716-7721, 2008
  • Nanochannels Fabricated in Polydimethylsiloxane Using Sacrificial Electrospun Polyethylene Oxide Nanofibers
    L. M. Bellan*, E. A. Strychalski*, and H. G. Craighead
    * These authors contributed equally
    Journal of Vacuum Science and Technology B, Vol. 26, No. 5, pp. 1728-1731, 2008
    Virtual Journal of Biological Physics Research
    Virtual Journal of Nanoscale Science and Technology
  • Non-Planar Nanofluidic Devices for Single Molecule Analysis Fabricated Using Nanoglassblowing
    E. A. Strychalski, S. M. Stavis, H. G. Craighead
    Nanotechnology, Vol. 19, No. 31, 315301, 2008
    Cover Article
  • Electrospun DNA Nanofibers
    L. M. Bellan, E. A. Strychalski, and H. G. Craighead
    Journal of Vacuum Science and Technology B, Vol. 25. pp. 2255-2257, 2008
    Virtual Journal of Nanoscale Science and Technology
  • Size-dependent Mobility in Nanochannels
    J. D. Cross, E. A. Strychalski, and H. G. Craighead
    Journal of Applied Physics, Vol. 102, No. 2, 024514, 2007
    Virtual Journal of Nanoscale Science and Technology
  • Individually Resolved DNA Molecules Stretched and Embedded in Electrospun Polymer Nanofibers
    L. M. Bellan, J. D. Cross, E. A. Strychalski, J. Moran-Mirabal, and H. G. Craighead
    Nano Letters, Vol. 6, No. 11, pp. 2526-2530, 2006

Publications

Genetic circuit design automation

April 01, 2016
Author(s):
Alec Nielsen, Bryan Der, Jonghyeon Shin, Prashant Vaidyanathan, Douglas Densmore, Vanya M. Paralanov, Elizabeth A. Strychalski, David J. Ross, Christopher Voigt
Computation can be performed in living cells using DNA-encoded circuits that process sensory information and control biological functions. Their construction...

Design and synthesis of a minimal bacterial genome

March 25, 2016
Author(s):
Elizabeth A. Strychalski, Clyde A. Hutchinson III, Ray-Yuan Chuang, Vladimir Noskov, Nacyra Assad-Garcia, Tom J. Deerinck, Mark H. Ellisman, John Gill, Krishna Kannan, Bogumil J. Karas, Li Ma, James F. Pelletier, Zhi-Qing Qi, Alexander Richter, Lijie Sun, Yo Suzuki, Billyana Tsvetanova, Kim S. Wise, Hamilton O. Smith, John I. Glass, Chuck Merryman, Daniel G. Gibson, J. C. Venter
We used whole-genome design and complete chemical synthesis to minimize the 1079–kilobase pair synthetic genome of Mycoplasma mycoides JCVI-syn1.0. An...

Dimensional Reduction of Duplex DNA Under Nanofluidic Slit Confinement

August 19, 2015
Author(s):
Luis Fernando Vargas Lara, Jack F. Douglas, Samuel M. Stavis, Elizabeth A. Strychalski, Jon C. Geist, Brian J. Nablo
There has been much recent interest in the dimensional properties of duplex DNA under nanoscale confinement conditions as a problem of fundamental interest in...
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