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Elizabeth A. Strychalski (Fed)
Group Leader, Cellular Engineering Group
Dr. Elizabeth A. Strychalski received a B.S. in Physics and a B.A. in Religious Studies from the University of Rochester and M.S. and Ph.D. in Physics from Cornell University. She was awarded a National Research Council Postdoctoral Research Associateship at the National Institute of Standards and Technology (NIST) in the areas of nanofabrication, nanofluidics, and confined biopolymers. Dr. Strychalski served as a Program Manager in the Biological Technology Office (BTO) at the Defense Advanced Research Projects Agency (DARPA), where she managed a ~$120M portfolio to aggressively advance experimental and theoretical research at the interface of synthetic biology, control engineering, nanobiotechnology, and fluidic devices. Upon returning to NIST, she founded the Cellular Engineering Group, as part of NIST’s Engineering Biology Program, and serves on the Steering Group for Build a Cell. Dr. Strychalski received the University of Rochester’s Harry W. Fullbright Prize and Janet Howell Clark Award, as well as the Maryland Academy of Sciences Young Scientist Award. Her current research focuses on discovering and testing fundamental rules to predict and control the engineered function of biological systems.
Postdoctoral Research Opportunities
National Research Council Research Associateship Program at NIST:
- Rolling application deadlines February 1 and August 1
- US citizens only
- ~ $79,000 annual salary plus benefits
- Please contact Dr. Strychalski directly and see the following link for further details:
Positions for non-US citizens:
- Please contact Dr. Strychalski directly
Selected Publications (Google Scholar)
- “Rise of synthetic yeast: Charting courses to new applications”
G.F. Taghon, E.A. Strychalski
Cell Genomics, Vol. 3, 100438, November 8, 2023 - “Design approaches to expand the toolkit for building cotranscriptionally encoded RNA strand displacement circuits”
S.W. Schaffter, M.E. Wintenberg, T.M. Murphy, E.A. Strychalski
ACS Synthetic Biology, Vol. 12, pp. 1546-1561, May 3, 2023 - “Advancing reproducibility can ease the ‘hard truths’ of synthetic biology”
M.W. Lux, E.A. Strychalski, G.J. Vora
Synthetic Biology, Oxford University Press, Vol. 8, January 1, 2023 - “Cellular mechanics during division of a genomically minimal cell”
J.F. Pelletier, J.I. Glass, E.A. Strychalski
Trends in Cell Biology, 10.1016/j.tcb.2022.06.009, July 27, 2022 - “Effects of DNA Template Preparation on Variability in Cell-Free Protein Production”
E. Romantseva, N. Alperovich, D.J. Ross, S.P. Lund, E.A. Strychalski
Synthetic Biology, Oxford University Press, Vol, 7., 10.1093/synbio/ysac015, August 13, 2022 - “Cotranscriptionally encoded RNA strand displacement circuits”
S.W. Schaffter, E.A. Strychalski
Science Advances, Vol. 8, 10.1126/sciadv.abl4354, March 23, 2022 - “Cell-free Gene Expression”
D. Garenne, M. Haines, E. Romantseva, P. Freemont, E.A. Strychalski, V. Noireaux
Nature Reviews Methods Primers, Vol. 1, pp. 49, 10.1038/s43586-021-00046-x, 2021 - “Comparison Of Bias And Resolvability In Single-Cell And Single-Transcript Methods”
J. Rammohan, S.P Lund, N. Alperovich, V. Paralanov, E.A. Strychalski, D.J. Ross
Nature Communications Biology, I10.1038/s42003-021-02138-6, 2021 - “Genetic Requirements For Cell Division In A Genomically Minimal Cell”
J. F. Pelletier, L. Sun, K. S. Wise, N. Assad-Garcia, B. J. Karas, T. J Deerinck, M. H. Ellisman, A. Mershin, N. Gershenfeld, R.-Y. Chuang, J. I. Glass, E. A. Strychalski
Cell, Vol. 184, No. 9, 10.1016/j.cell.2021.03.008, 2021 - “Measurements Drive Progress And Opportunities In Directed Evolution For Precise Engineering Of Biological Systems”
D. S. Tack, E. F. Romantseva, P. D. Tonner, A.D. Pressman, J. Rammohan, E.A. Strychalski
Current Opinion in Structural Biology, Vol. 23, p.p. 32-37, 10.1016/j.coisb.2020.09.004, 2020 - “Organizing Genome Engineering For The Gigabase Scale”
B.A. Bartley, J. Beal, J.R. Karr, E. A. Strychalski
Nature Communications, Vol. 11, No. 689, 10.1038/s41467-020-14314-z, 2020 - “Cyberbiosecurity for Biopharmaceutical Products"
J. L. Mantle, J. Rammohan, E. F. Romantseva, J. T. Welch, L.R. Kauffman, J. McCarthy, J. Schiel, J. C. Baker, E.A. Strychalski, K. C. Rogers, K.H. Lee Frontiers in Bioengineering and Biotechnology, 10.3389/fbioe.2019.00116, 2019 - “Equilibrium Free Energies From Non-equilibrium Trajectories with Relaxation Fluctuation Spectroscopy”
D. Ross, E.A. Strychalski, C. Jarzynski, S.M. Stavis
Nature Physics, 10.1038/s41567-018-0153-5, 2018 - “Genetic Circuit Design Automation”
A.A. K. Nielsen, B.S. Der, J. Shin, P. Vaidyanathan, V. Paralanov, E.A. Strychalski, D. Ross, D. Densmore, C.A. Voigt Science, Vol. 352, No. 6281, 10.1126/science.aac7341, 2016 - “Design and synthesis of a minimal bacterial genome”
C. A. Hutchison, III, R.-Y. Chuang, V. N. Noskov, N. Assad-Garcia, T. J. Deerinck, M. H. Ellisman, J. Gil, K. Kannan, B. J. Karas, L. Ma, J. F. Pelletier, Z.-Q. Qi, R. A. Richter, E. A. Strychalski, L. Sun, Y. Suzuki, B. Tsvetanova, K. S. Wise, H. O. Smith, J. I. Glass, C. Merryman, D. G. Gibson, J. C. Venter Science, Vol. 351, No. 6280, 10.1126/science.aad6253, 2016 - “Rapid Prototyping of Nanofluidic Slits in a Silicone Bilayer”
T. P. Kole, K.-T. Liao, D. Schiffels, B. R. Ilic, E. A. Strychalski, J. G. Kralj, J. A. Liddle, A. Dritschilo, S. M. Stavis
Journal of Research of the National Institute of Standards and Technology, Vol. 120, pp.252-269, 2015 - “Dimensional Reduction of Duplex DNA Under Confinement to Nanofluidic Slits”
F. Vargas-Lara, S. M. Stavis, E. A. Strychalski, B. J. Nablo, J. Geist, F. W. Starr, J. F. Douglas
Soft Matter, Vol. 11, pp. 8273-8284, 2015 - DNA Purification From Crude Samples for Human Identification Using Gradient Elution Isotachophoresis
E.A. Strychalski, C. Konek, E. R. Butts, P. M. Valone, A. C. Henry, D. Ross
Electrophoresis, Vol. 34, No. 17, pp. 2522-2530, 2013 - A localized transition in the size variation of circular DNA in nanofluidic slitlike confinement
E. A. Strychalski*, S. M. Stavis*, J. Geist*
* These authors contributed equally
AIP Advances, Vol. 3, No. 4, 042115, 2013 - Quantitative Size Measurements of Linear and Circular DNA in Nanofluidic Slitlike Confinement
E. A. Strychalski*, J. Geist, M. Gaitan, L. E. Locascio, S. M. Stavis*
* These authors contributed equally
Macromolecules, Vol. 45, No. 3, pp. 16021611, 2012 - DNA Molecules Descending a Nanofluidic Staircase by Entropophoresis
S. M. Stavis*, J. Geist, M. Gaitan, L. E. Locascio, E. A. Strychalski*
* These authors contributed equally
Lab on a Chip, Vol.12, No. 6, pp. 11741182, 2012
Virtual Journal of Biological Physics Research - Expanding the Capabilities of Microfluidic Gradient Elution Moving Boundary Electrophoresis for Complex Samples
E. A. Strychalski, A. C. Henry, D. Ross
Analytical Chemistry, Vol. 83, No. 16, pp. 63166322, 2011 - Microfluidic Analysis of Complex Samples With Minimal Sample Preparation Using Gradient Elution Moving Boundary Electrophoresis
E. A. Strychalski, A. C. Henry, D. Ross
Analytical Chemistry, Vol. 81, No. 24, pp. 1020110207, 2009 Cover Article - Non-equilibrium Length-based Separation of Short DNA using Nanoslit Arrays
E. A. Strychalski, H. W. Lau, L. A. Archer
Journal of Applied Physics, Vol. 106, No. 2, 024915, 2009 Virtual Journal of Biological Physics Research - Nanofluidic Structures with Complex Three Dimensional Surface Topographies
S. M. Stavis, E. A. Strychalski, M. Gaitan
Nanotechnology, Vol. 20, No. 16, 165302, 2009
Featured in Nanotechnology 2009 Highlights collection - Diffusion of DNA in Nanoslits
E. A. Strychalski*, S. Levy*, and H. G. Craighead
* These authors contributed equally
Macromolecules, Vol. 41, No. 20, pp. 7716-7721, 2008 - Nanochannels Fabricated in Polydimethylsiloxane Using Sacrificial Electrospun Polyethylene Oxide Nanofibers
L. M. Bellan*, E. A. Strychalski*, and H. G. Craighead
* These authors contributed equally
Journal of Vacuum Science and Technology B, Vol. 26, No. 5, pp. 1728-1731, 2008
Virtual Journal of Biological Physics Research
Virtual Journal of Nanoscale Science and Technology - Non-Planar Nanofluidic Devices for Single Molecule Analysis Fabricated Using Nanoglassblowing
E. A. Strychalski, S. M. Stavis, H. G. Craighead
Nanotechnology, Vol. 19, No. 31, 315301, 2008
Cover Article - Electrospun DNA Nanofibers
L. M. Bellan, E. A. Strychalski, and H. G. Craighead
Journal of Vacuum Science and Technology B, Vol. 25. pp. 2255-2257, 2008
Virtual Journal of Nanoscale Science and Technology - Size-dependent Mobility in Nanochannels
J. D. Cross, E. A. Strychalski, and H. G. Craighead
Journal of Applied Physics, Vol. 102, No. 2, 024514, 2007
Virtual Journal of Nanoscale Science and Technology - Individually Resolved DNA Molecules Stretched and Embedded in Electrospun Polymer Nanofibers
L. M. Bellan, J. D. Cross, E. A. Strychalski, J. Moran-Mirabal, and H. G. Craighead
Nano Letters, Vol. 6, No. 11, pp. 2526-2530, 2006
Awards
Maryland Academy of Sciences Outstanding Young Scientist, Non-Academic for 2019-20