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Search Publications by Elizabeth Strychalski

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Displaying 1 - 18 of 18

Genetic circuit design automation

April 1, 2016
Alec Nielsen, Bryan Der, Jonghyeon Shin, Prashant Vaidyanathan, Douglas Densmore, Vanya M. Paralanov, Elizabeth A. Strychalski, David J. Ross, Christopher Voigt
Computation can be performed in living cells using DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. We

Design and synthesis of a minimal bacterial genome

March 25, 2016
Elizabeth A. Strychalski, Clyde A. Hutchinson III, Ray-Yuan Chuang, Vladimir Noskov, Nacyra Assad-Garcia, Tom J. Deerinck, Mark H. Ellisman, John Gill, Krishna Kannan, Bogumil J. Karas, Li Ma, James F. Pelletier, Zhi-Qing Qi, Alexander Richter, Lijie Sun, Yo Suzuki, Billyana Tsvetanova, Kim S. Wise, Hamilton O. Smith, John I. Glass, Chuck Merryman, Daniel G. Gibson, J. C. Venter
We used whole-genome design and complete chemical synthesis to minimize the 1079–kilobase pair synthetic genome of Mycoplasma mycoides JCVI-syn1.0. An initial design, based on collective knowledge of molecular biology combined with limited transposon

Dimensional Reduction of Duplex DNA Under Nanofluidic Slit Confinement

August 19, 2015
Luis Fernando Vargas Lara, Jack F. Douglas, Samuel M. Stavis, Elizabeth A. Strychalski, Jon C. Geist, Brian J. Nablo
There has been much recent interest in the dimensional properties of duplex DNA under nanoscale confinement conditions as a problem of fundamental interest in both technological and biological fields. This has led to a series of measurements by

DNA Molecules Descending a Nanofluidic Staircase by Entropophoresis

January 26, 2012
Samuel M. Stavis, Jon C. Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth A. Strychalski
A complex entropy gradient for confined DNA molecules was engineered for the first time. Following the second law of thermodynamics, this enabled the directed self-transport and self-concentration of DNA molecules. This new nanofluidic method is termed


October 3, 2011
Samuel M. Stavis, Jon C. Geist, Michael Gaitan, Laurie E. Locascio, Elizabeth A. Strychalski
Entropophoresis – motion caused by an entropy gradient – is a novel nanofluidic method to direct the self-transport of biopolymers that established a new paradigm of nanofluidic functionality with broad relevance to lab-on-a-chip technol-ogy. Here, the

Nanoslinky: DNA Entropophoresis Down a Nanofluidic Staircase

October 4, 2010
Elizabeth A. Strychalski, Laurie E. Locascio, Samuel M. Stavis, Michael Gaitan
Almost all nanofluidic devices for biopolymer analysis have been limited by one or two confining structural dimen-sions or the application of external forces for biopolymer manipulation, which has restricted the scope of related lab-on-a-chip technology