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Search Publications by: Nancy Lin (Fed)

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Displaying 51 - 74 of 74

Effects of Polymeric Nanogratings on Cell Orientation

December 30, 2010
Author(s)
Nancy J. Lin, Sheng Lin-Gibson, Jirun Sun, Yifu Ding
Surface topography is known to play a critical role in the biological response to materials, with surface features on the order of both microns and nanometers altering cell response, including morphology, adhesion, cytoskeletal orientation, and gene

Cell Contact Guidance in Response to Nanopattern Shape and Height

October 18, 2010
Author(s)
Sheng Lin-Gibson, Jirun Sun, Nancy J. Lin, Jing N. Zhou, Hyun W. Ro, Christopher L. Soles, Marcus T. Cicerone, Yifu Ding
Understanding the correlation between cell contact guidance (CG) and nanoscale surface features is vital in designing advanced medical devices to manipulate cell behaviors. Nanoscale surface features that mimic extracellular matrix are critical

PHOTOPOLYMERIZED DIMETHACRYLATE POLYMERS CONTAINING IN SITU GENERATED SILVER NANOPARTICLES

August 21, 2010
Author(s)
Yajun Cheng, Xinran Zhang, Diana N. Zeiger, Nancy Lin, Joseph M. Antonucci, Sheng Lin-Gibson
Polymeric nanocomposites containing silver are known to exhibit antibacterial activity. Here we demonstrate the synthesis and characterization of dimethacrylate/silver nanocomposites by coupling photopolymerization with in situ silver ion reduction. An

Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies

August 17, 2010
Author(s)
Yifu Ding, Jirun Sun, Hyun W. Ro, Zhen Wang, Jing N. Zhou, Nancy J. Lin, Sheng Lin-Gibson, Marcus T. Cicerone, Christopher L. Soles
Cells sense and respond to the chemical, topographical, and mechanical features of their substrate and extracellular matrix. Shape and locomotive response to these features is termed contact guidance (CG) and is of vital importance in understanding many

Novel Dimethacrylates with Quaternary Ammonium Functionalities for Reduced Bacteria Adhesion

April 1, 2010
Author(s)
Nancy Lin, Joseph M. Antonucci, Diana N. Zeiger, Kathy Tang, Bruce O. Fowler, Sheng Lin-Gibson
Biofilm growth and secondary caries have resulted in the failure of many dental composite restorations. One approach to address this issue is the modification of dental materials to reduce bacterial adhesion and biofilm growth. Quaternary ammonium salts

Effects of sample preparation on bacterial colonization of polymers

October 19, 2009
Author(s)
Diana N. Zeiger, Christopher Stafford, Yajun Cheng, Stefan D. Leigh, Sheng Lin-Gibson, Nancy Lin
Characterization of materials developed for medical usage frequently includes studies in which the materials are inoculated with bacteria in order to assess biofilm formation. Differences in the bacteria are considered to be due to the material alone; the

Microbial colonization on polymers: Effects of sample preparation and incorporation of quaternary ammonium salts

September 13, 2009
Author(s)
Nancy Lin, Diana N. Zeiger, Joseph M. Antonucci, Bruce O. Fowler, Christopher Stafford, Sheng Lin-Gibson
Controlling bacterial growth in the oral environment presents many challenges. To address these challenges, new materials and treatments are needed along with controlled, reproducible methods to evaluate their efficacy. In this study, a reproducible method

Effects of filler type and content on mechanical properties of photopolymerizable composites determined using a two-dimensional gradient platform

February 5, 2009
Author(s)
Sheng Lin-Gibson, Li Piin Sung, Haiqing Hu, Aaron M. Forster, Nancy J. Lin
Photopolymerizable dental composites have complex processing conditions and multi-component formulations that affect the final properties. Combinatorial screening is a useful approach for evaluating multiple properties of the composites. A single test

Monitoring Alignment of Osteoblast Cells Directed by Gradient Nanopatterns

April 6, 2008
Author(s)
Jirun Sun, Yifu Ding, Nancy J. Lin, Hyun Wook Ro, Christopher L. Soles, Sheng Lin-Gibson
We investigated the behavior of pre-osteoblasts cultured on polystyrene and photopolymerized ethoxylated bisphenol-A dimethacrylate gradient patterns. Gradient patterns varying in height from several hundred to 0 nm were prepared using nanoimprinting

Mapping Cell Distribution in Amorphous Scaffolds using Confocal Microscopy

August 19, 2007
Author(s)
Jirun Sun, Nancy Lin, Marcus T. Cicerone, Sheng Lin-Gibson
One common method for probing cell-material interactions is direct visualization via confocal laser scanning microscopy, a technique widely used for studying biological systems. However, confocal microscopy has limited depth penetration for imaging cells

Rapid Assessment of Dental Polymers Using Gradient Samples

April 18, 2007
Author(s)
Nancy J. Lin, Peter Drzal, Sheng Lin-Gibson
Dental composites are widely used yet still face challenges including incomplete conversion, polymerization shrinkage, and poor adhesion to tooth structures. High-throughput techniques to quickly assess several material properties in a combinatorial manner

Macrophage Response to Methacrylate Conversion Using a Gradient Approach

January 1, 2007
Author(s)
Nancy Lin, L A. Bailey, Matthew Becker, N. R. Washburn, Lori Henderson
Incomplete conversion, an ongoing challenge facing photopolymerized methacrylate-based polymers, affects leachables as well as the resulting network. As novel polymers and composites are developed, methods to efficiently screen cell response to these

High-Throughput Evaluation of Restorative Dental Polymers

March 31, 2006
Author(s)
Sheng Lin-Gibson, Forrest A. Landis, Nancy J. Lin
The effects of co-monomer composition and irradiation time on material properties and cell response were determined using high-throughput and combinatorial methods. 2-Dimensional gradient samples varying in monomer composition and light exposure time were
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