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Monitoring of elongation and orientation of osteoblast cells directed by anisotropic nanopatterns

Published

Author(s)

Jirun Sun, Yifu Ding, Nancy Lin, Marcus T. Cicerone, Christopher Soles, Sheng Lin-Gibson

Abstract

The time dependence of cell alignment and morphology (i.e., elongation) on anisotropic nanoscale gratings is characterized. The behavior of pre-osteoblasts cultured on nanoscale gradient patterns of transparent photopolymerized dimethacrylates was quantified. Grating patterns had a 200 nm or 400 nm line width and a corresponding 400 nm or 800 nm pitch. The pattern height decreased from several hundred nanometers on one end of the substrate to a flat surface on the other end of the substrate in continuous fashion. The morphology change of the cells on these patterns was studied, and cell alignment along the pattern and cell elongation as a function of pattern height were examined as a function of incubation time.
Proceedings Title
American Chemical Society Division of Polymer Chemistry|237th | |ACS
Conference Dates
March 22-26, 2009
Conference Location
Salt Lake City, UT, US
Conference Title
Polymer Preprints

Keywords

nanoimprint, cell response, alignment, live cell imaging, combinatorial

Citation

Sun, J. , Ding, Y. , Lin, N. , Cicerone, M. , Soles, C. and Lin-Gibson, S. (2009), Monitoring of elongation and orientation of osteoblast cells directed by anisotropic nanopatterns, American Chemical Society Division of Polymer Chemistry|237th | |ACS, Salt Lake City, UT, US, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=900868 (Accessed February 23, 2024)
Created March 21, 2009, Updated October 12, 2021