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Search Publications by: Bryant C. Nelson (Fed)

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Displaying 26 - 50 of 78

Measurement of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human tissues by liquid chromatography/tandem mass spectrometry with isotope dilution

June 5, 2016
Author(s)
Pawel Jaruga, Guldal Kirkali, Prasad T. Reddy, Alessandro Tona, Bryant C. Nelson, Li Mengxia, David M. Wilson III, Erdem Coskun, M Miral Dizdar
Introduction DNA repair proteins may be used as biomarkers in disease etiology and therapy. Thus, the accurate determination of DNA repair protein expression and genotype in human tissues is of fundamental importance. Apurinic/apyrimidinic endonuclease 1

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine

May 17, 2016
Author(s)
Bryant C. Nelson, Monique E. Johnson, Marlon L. Walker, Kathryn R. Riley, Christopher M. Sims
Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the

GC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ENMs to

GC/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ENMs to

LC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. However, the unique behaviors of ENMs may cause artifacts in

Production, Purification and Characterization of 15N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements

July 26, 2015
Author(s)
Prasad T. Reddy, Pawel Jaruga, Bryant C. Nelson, Mark Lowenthal, Ann-Sofie Jemth, Olga Loseva, Erdem Coskun, Thomas Helleday, Miral M. Dizdar
Oxidatively induced DNA damage is caused in living organisms by a variety of damaging agents, resulting in the formation of a multiplicity of lesions, which are mutagenic and cytotoxic. Unless repaired by DNA repair mechanisms before DNA replication, DNA

Assessment of Crude Oil and a Dispersant in a Simulated Spartina alterniflora Salt Marsh Ecosystem

December 1, 2014
Author(s)
P Key, K Chung, C Cooksey, DeLorenzo M, M Fulton, D Greenfield, T Greig, J Hylund, Bryant C. Nelson, Varun Patel, P Pennington, Elijah Petersen, E Wirth
NOAA's Environmental Sensitivity Index (ESI) lists saltmarshes along the Atlantic and Gulf Coasts as the most vulnerable habitat to oil spills. As a result of the Deepwater Horizon offshore drilling rig accident, more that 200 million gallons of crude oil

The DNA Damaging Potential of Photoactivated P25 Titanium Dioxide Nanoparticles

September 30, 2014
Author(s)
Elijah Petersen, Vytas Reipa, Stephanie S. Watson, Deborah Jacobs, Savelas A. Rabb, Bryant C. Nelson
Titanium dioxide nanoparticles (TiO2 NPs) are found in numerous commercial and personal care products. Thus, it is necessary to understand and characterize their potential environmental health and safety risks. It is well known that photoactivated TiO2 NPs

Using Single Particle ICP-MS as a Tool for Understanding Metallic Nanoparticle Transformation during Nanotoxicity Assays

July 1, 2014
Author(s)
Monique E. Johnson, Shannon Hanna, Antonio R. Montoro Bustos, Bryant C. Nelson, Elijah J. Petersen, Lee L. Yu
The advent of engineered nanoparticles (ENPs) and their increased use has remarkably improved the performance of basic materials and consumer products, but has also increased the potential for ENP release into the environment. Technical procedures, more

Development of a Standard Reference Material for Metabolomics Research

November 4, 2013
Author(s)
Karen W. Phinney, Guillaume Ballihaut, Mary Bedner, Johanna Camara, Steven J. Christopher, William C. Davis, Nathan G. Dodder, Brian E. Lang, Stephen E. Long, Mark S. Lowenthal, Elizabeth A. McGaw, Karen E. Murphy, Bryant C. Nelson, Jocelyn L. Prendergast, Jessica L. Reiner, Catherine A. Rimmer, Lane C. Sander, Michele M. Schantz, Katherine E. Sharpless, Lorna T. Sniegoski, Susan S. Tai, Jeanice M. Brown Thomas, Thomas W. Vetter, Michael J. Welch, Stephen A. Wise, Laura J. Wood, William F. Guthrie, Robert C. Hagwood, Stefan D. Leigh, James H. Yen, Nien F. Zhang, Madhu Chaurhary-Webb, Huiping Chen, Bridgette Haynes, Donna J. LaVoie, Leslie F. McCoy, Shahzad S. Momin, Neelima Paladugula, Elizabeth C. Pendergrast, Christine M. Pfeiffer, Carissa D. Powers, Zia Fazili-Qari, Daniel Rabinowitz, Michael E. Rybak, Rosemary L. Schleicher, Mary Xu, Mindy Zhang, Arthur L. Castle, Brandi S. Benford, Gauthier Eppe

Functionalization-Dependent Induction of Cellular Survival Pathways by CdSe Quantum Dots in Primary Normal Human Bronchial Epithelial Cells

September 5, 2013
Author(s)
Amber Nagy, Jennifer A. Hollingsworth, Bin Hu, Andrea Steinbruck, Peter C. Stark, Cristina Rios Valdez, Momchilo Vuyisich, Michael H. Stewart, Donald H. Atha, Bryant C. Nelson, Rashi Iyer
Quantum dots (QDs) are semiconductor nanocrystals exhibiting unique optical properties which can be exploited for many practical applications ranging from photovoltaics to biomedical imaging and drug delivery. They are increasingly manufactured in large

Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

July 29, 2013
Author(s)
Guldal Kirkali, Pawel Jaruga, Prasad T. Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C. Nelson
Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

May 13, 2013
Author(s)
Elijah J. Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair

Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans

May 2, 2013
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Piper R. Hunt, Katherine M. Tyner, Sean Conklin, Nicholas Olejnik, Robert L. Sprando
The utility of C. elegans as an alternative model to assess nanomaterial toxicity was evaluated using 10 nm silver particles (10nmAg). Endpoints of nanomaterial uptake and localization, larval growth, morphology, and DNA damage were assessed. Orally

Active Transcriptomic and Proteomic Reprogramming in the C. elegans Nucleotide Excision Repair Mutant xpa-1

April 10, 2013
Author(s)
Katarzyna Arczewska, Gisele Tomazella, Jessica Lindvall, Henok Kassahun, Silvia Maglioni, Alessandro Torgovnick, Johan Henriksson, Olli Matilainen, Bryce J. Marquis, Bryant C. Nelson, Eshrat Babaie, Carina Holmberg, Thomas Burglin, Natascia Ventura, Bernd Thiede, Hilde Nilsen
Transcription-blocking oxidative DNA damage is believed to contribute to aging and to underlie activation of oxidative stress-responses and down-regulation of insulin-like signaling (ILS) in Nucleotide Excision Repair (NER) deficient mice. Here, we present

NIST Gold Nanoparticle Reference Materials Do Not Induce Oxidative DNA Damage

February 1, 2013
Author(s)
Bryant C. Nelson, Donald H. Atha, John T. Elliott, Bryce J. Marquis, Elijah J. Petersen, Danielle Cleveland, Stephanie S. Watson, I-Hsiang Tseng, Andrew Dillon, Melissa Theodore, Joany Jackman
Well-characterized, nanoparticle reference materials are urgently needed for nanomaterial toxicity studies. The National Institute of Standards and Technology has developed three gold nanoparticle (AuNP) reference materials (10 nm, 30 nm, 60 nm) to address

Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

December 26, 2012
Author(s)
M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C. Nelson, Gamze Tuna, Prasad T. Reddy
Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpression or

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

June 20, 2012
Author(s)
Elijah J. Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair

Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using 15N-labeled whole proteins as internal standards

May 30, 2012
Author(s)
M Miral Dizdar, Prasad T. Reddy, Guldal Kirkali, Gamze Tuna, Bryant C. Nelson, Pawel Jaruga
Oxidatively induced DNA damage is implicated in disease, unless it is repaired by DNA repair. DNA repair proteins may be used as early detection and therapeutic biomarkers in cancer and other diseases. For this purpose, the measurement of the expression

Pro-oxidant Induced DNA Damage in Human Lymphoblastoid Cells: Homeostatic Mechanisms of Genotoxic Tolerance

April 26, 2012
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Anna L. Seager, Ume K. Shah, Jane M. Mikhail, Shareen H. Doak, George E. Johnson, Paul L. Carmichael, Sharon J. Scott, Andrew D. Scott, Gareth J. Jenkins
Oxidative stress contributes to many disease aetiologies including ageing, neurodegeneration, and cancer, partly through DNA damage induction (genotoxicity). Understanding the interactions of free radicals with DNA is fundamental to discern the mutation